The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Alieva Fi.T.

I.M. Sechenov First Moscow State Medical University

Bryunin D.V.

Sechenov First Moscow State University (Sechenov University)

Aleksankin A.P.

B.V. Petrovsky Russian Scientific Center of Surgery

Tikhonova N.B.

B.V. Petrovsky Russian Scientific Center of Surgery

Artem’eva K.A.

B.V. Petrovsky Russian Scientific Center of Surgery

Aleksankina V.V.

B.V. Petrovsky Russian Scientific Center of Surgery

Boltovskaya M.N.

Avtsyn Research Institute of Human Morphology of «Petrovsky National Research Centre of Surgery»

Bakhvalova A.A.

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation

Alieva F.T.

I.M. Sechenov First Moscow State Medical University

Diagnostic significance of transforming growth factor-β1, tumor necrosis factor-α and glycodelin A in endometrial pathology in pre- and postmenopausal periods

Authors:

Alieva Fi.T., Bryunin D.V., Aleksankin A.P., Tikhonova N.B., Artem’eva K.A., Aleksankina V.V., Boltovskaya M.N., Bakhvalova A.A., Alieva F.T.

More about the authors

Journal: Russian Bulletin of Obstetrician-Gynecologist. 2022;22(4): 25‑30

DOI: 10.17116/rosakush20222204125

Read: 2889 times

Download PDF (RU)
Contact the author
Table of contents

DIAGNOSTIC SIGNIFICANCE OF TRANSFORMING GROWTH FACTOR-Β1, TUMOR NECROSIS FACTOR-Α AND GLYCODELIN A IN ENDOMETRIAL PATHOLOGY IN PRE- AND POSTMENOPAUSAL PERIODS
DIAGNOSTIC SIGNIFICANCE OF TRANSFORMING GROWTH FACTOR-Β1, TUMOR NECROSIS FACTOR-Α AND GLYCODELIN A IN ENDOMETRIAL PATHOLOGY IN PRE- AND POSTMENOPAUSAL PERIODS

To cite this article:

Alieva FiT, Bryunin DV, Aleksankin AP, et al. Diagnostic significance of transforming growth factor-β1, tumor necrosis factor-α and glycodelin A in endometrial pathology in pre- and postmenopausal periods. Russian Bulletin of Obstetrician-Gynecologist. 2022;22(4):25‑30. (In Russ.)
https://doi.org/10.17116/rosakush20222204125

Подписка 2026 Российский вестник акушера-гинеколога (Russian Bulletin of Obstetrician-Gynecologist)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Scle­roatrophic lichen of the vulva: is it possible to solve the problem?. Russian Bulletin of Obstetrician-Gynecologist. 2025;(5):47-53
Hype­rtensive diso­rders of pregnancy as a risk factor for chro­nic non-communicable diseases. Russian Journal of Preventive Medi­cine. 2025;(6):114-119
Abstract:

PURPOSE OF THE STUDY

To study the diagnostic significance of TGF-β1, TNF-α and GdA in endometrial pathology in the pre- and postmenopausal periods.

MATERIAL AND METHODS

120 women with various endometrial pathologies were examined: 73 patients in the premenopausal period (the1st main group) and 47 patients in the postmenopausal period (the 2nd main group). The control groups consisted of women in the premenopausal period (n=10) and in the postmenopausal period (n=10) who had no endometrial pathology. Levels of glycodelin A (GdA) and transforming growth factor (TGF)-β in serum were determined in all patients by enzyme immunoassay (ELISA). The level of expression of TGF-β and tumor necrosis factor (TNF)-α was determined in all patients, based on measuring the amount of mRNA of the gene of interest in endometrial tissues by polymerase chain reaction (PCR) in «real time».

RESULTS

Indicators of the level of TGF-β in the serum of patients with endometrial pathology in premenopause were significantly lower in comparison with those of the control group. Significantly higher levels of glycodelin A were revealed in premenopausal women in comparison with the postmenopausal group. TNF-α gene expression was higher in postmenopausal patients with endometrial pathology. Pathological changes in the endometrium in premenopause were accompanied by a systemic decrease in TGF-β and an increase in GdA. At the same time, postmenopausal endometrial pathology was accompanied by local changes representing a local increase in TNF-α expression.

Keywords:

glycodelin A (GdA)
transforming growth factor (TGF)-β
tumor necrosis factor (TNF)-α
endometrial pathology
premenopausal period
postmenopausal period

Authors:

Alieva Fi.T.

I.M. Sechenov First Moscow State Medical University

Bryunin D.V.

Sechenov First Moscow State University (Sechenov University)

Aleksankin A.P.

B.V. Petrovsky Russian Scientific Center of Surgery

Tikhonova N.B.

B.V. Petrovsky Russian Scientific Center of Surgery

Artem’eva K.A.

B.V. Petrovsky Russian Scientific Center of Surgery

Aleksankina V.V.

B.V. Petrovsky Russian Scientific Center of Surgery

Boltovskaya M.N.

Avtsyn Research Institute of Human Morphology of «Petrovsky National Research Centre of Surgery»

Bakhvalova A.A.

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation

Alieva F.T.

I.M. Sechenov First Moscow State Medical University

Received:

04.04.2022

Accepted:

25.04.2022

Close metadata

References:

  1. Balik G, Kagitci M, Ustuner I, Akpinar F, Guvendag Guven ES. Which endometrial pathologies need intraoperative frozen sections? Asian Pac J Cancer Prev. 2013;14:10:6121-6125. https://doi.org/10.7314/apjcp.2013.14.10.6121
  2. Endometrial cancer. Practice Bulletin N 149. American College of Obstetricians and Gynecologists. Obstet Gynecol. 2015;125:1006-1026.
  3. Pandey J, Yonder S. Premalignant lesions of the endometrium. 2021;9. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022.
  4. Kapitanova OV, Chechneva MA. Endometrial hyperplasia in peri- and postmenopausal women. Rossiiskii vestnik akushera-ginekologa. 2020;20:3:35-40. (In Russ.). https://doi.org/10.17116/rosakush20202003135
  5. Ragupathy K, Cawley N, Ridout A, Iqbal P, Alloub M. Nonassessable endometrium in women with post-menopausal bleeding: to investigate or ignore. Arch Gynecol Obstet. 2013;288:375-378. 
  6. Ivanov IA, Asaturova AV, Chernukha GE, Dumanovskaya MR, Mnikhovich MV. The role of pathological neoangiogenesis in the formation of endometrial polyps and the mechanisms of abnormal uterine bleedings. Klinicheskaya i eksperimental’naya morfologiya. 2019;8:2:28-34. (In Russ.). https://doi.org/10.31088/2226-5988-2019-30-2-28-34
  7. Chatzaki E, Kouimtzoglou E, Margioris AN, Gravanis A. Transforming growth factor beta1 exerts an autocrine regulatory effect on human endometrial stromal cell apoptosis, involving the FasL and Bcl-2 apoptotic pathways. Mol Hum Reprod. 2003;9:2:91-95.  https://doi.org/10.1093/molehr/gag011
  8. Eritja N, Felip I, Dosil MA, Vigezzi L, Mirantes C, Yeramian A, Navaridas R, Santacana M, Llobet-Navas D, Yoshimura A, Nomura M, Encinas M, Matias-Guiu X, Dolcet X. A Smad3-PTEN regulatory loop controls proliferation and apoptotic responses to TGF-β in mouse endometrium. Cell Death Differ. 2017;24:8:1443-1458. https://doi.org/10.1038/cdd.2017.73
  9. Ben-Neriah Y, Karin M. Inflammation meets cancer, with NF-κB as the matchmaker. Nat Immunol. 2011;12:8:715-723.  https://doi.org/10.1038/ni.2060
  10. Trabert B, Eldridge RC, Pfeiffer RM, Shiels MS, Kemp TJ, Guillemette C, Hartge P, Sherman ME, Brinton LA, Black A, Chaturvedi AK, Hildesheim A, Berndt SI, Safaeian M, Pinto L, Wentzensen N. Prediagnostic circulating inflammation markers and endometrial cancer risk in the prostate, lung, colorectal and ovarian cancer (PLCO) screening trial. Int J Cancer. 2017;140:3:600-610.  https://doi.org/10.1002/ijc.30478
  11. Salama SA, Kamel MW, Diaz-Arrastia CR, Xu X, Veenstra TD, Salih S, Botting SK, Kumar R. Effect of tumor necrosis factor-alpha on estrogen metabolism and endometrial cells: potential physiological and pathological relevance. J Clin Endocrinol Metab. 2009;94:1:285-293.  https://doi.org/10.1210/jc.2008-1389
  12. Wieser V, Abdel Azim S, Sprung S, Knoll K, Kögl J, Hackl H, Marth C, Zeimet AG, Fiegl H. TNF-α signalling predicts poor prognosis of patients with endometrial cancer. Carcinogenesis. 2020;41:8:1065-1073. https://doi.org/10.1093/carcin/bgaa034
  13. Garcia FU, Chen HL, Yang Y, Pace JL, Hu XL, Hunt JS. Tumor necrosis factor-alpha mRNA and protein in endometrial tumors: analysis by in situ hybridization and immunocytochemistry. Hum Pathol. 1994;25:12:1324-1331. https://doi.org/10.1016/0046-8177(94)90093-0
  14. Uzan J, Laas E, Alsamad IA, Skalli D, Mansouri D, Haddad B, Touboul C. Supervised clustering of adipokines and hormonal receptors predict prognosis in a population of obese women with type 1 endometrial cancer. Int J Mol Scie. 2017;18:5:1055.
  15. Wieser V, Tsibulak I, Degasper C, Welponer H, Leitner K, Parson W, Zeimet AG, Marth C, Fiegl H. Tumor necrosis factor receptor modulator spermatogenesis-associated protein 2 is a novel predictor of outcome in ovarian cancer. Cancer Sci. 2019;110:3:1117-1126. https://doi.org/10.1111/cas.13955
  16. Haider S, Knöfler M. Human tumour necrosis factor: physiological and pathological roles in placenta and endometrium. Placenta. 2009;30:2:111-123.  https://doi.org/10.1016/j.placenta.2008.10.012
  17. Alok A, Mukhopadhyay D, Karande AA. Glycodelin A, an immunomodulatory protein in the endometrium, inhibits proliferation and induces apoptosis in monocytic cells. Int J Biochem Cell Biol. 2009;41:5:1138-1147. https://doi.org/10.1016/j.biocel.2008.10.009
  18. Cui J, Liu Y, Wang X. The roles of glycodelin in cancer development and progression. Front Immunol. 2017;8:1685. https://doi.org/10.3389/fimmu.2017.01685
  19. Metcalf CA, Johnson RL, Freeman EW, Sammel MD, Epperson CN. Influences of the menopause transition and adverse childhood experiences on peripheral basal inflammatory markers. Brain Behav Immun Health. 2021;15:100280. https://doi.org/10.1016/j.bbih.2021.100280
  20. Taleb-Belkadi O, Chaib H, Zemour L, Fatah A, Chafi B, Mekki K. Lipid profile, inflammation, and oxidative status in peri- and postmenopausal women. Gynecol Endocrinol. 2016;32:12:982-985.  https://doi.org/10.1080/09513590.2016.1214257
  21. Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, Speleman F. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 2002;3:7:0034.1-0034.11.  https://doi.org/10.1186/gb-2002-3-7-research0034
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.