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Shvarev E.G.

Astrakhan State Medical University

Dikareva L.V.

Astrakhan State Medical University

Ayupova A.K.

Astrakhan State University

Zoeva A.R.

Astrakhan State Medical University

Ukhanova Yu.Yu.

Astrakhan State Medical University

Markers of menstrual flow in the diagnosis of endometrial pathology

Authors:

Shvarev E.G., Dikareva L.V., Ayupova A.K., Zoeva A.R., Ukhanova Yu.Yu.

More about the authors

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To cite this article:

Shvarev EG, Dikareva LV, Ayupova AK, Zoeva AR, Ukhanova YuYu. Markers of menstrual flow in the diagnosis of endometrial pathology. Russian Bulletin of Obstetrician-Gynecologist. 2022;22(2):71‑78. (In Russ.)
https://doi.org/10.17116/rosakush20222202171

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References:

  1. Klinyshkova TV, Turchaninov DV, Frolova NB. Clinical and epidemiological aspects of uterine body cancer from the position of preventing recurrence of endometrial hyperplasia. Akusherstvo i ginekologiya. 2020;1:135-140. (In Russ.). https://doi.org/10.18565/aig.2020.1.135-140
  2. Marie-Hélène Auclair, Paul J Yong, Shannon Salvador, Jackie Thurston, Terence Terry J Colgan, Alexandra Sebastianelli. Guideline No. 392. Classification and management of endometrial hyperplasia. J Obstet Gynaecol. 2019;41:12:1789-1800. https://doi.org/10.1016/j.jogc.2019.03.025
  3. Caprin AD, Starinskii VV, Petrova GV. Malignant neoplasms in Russia in 2017 (morbidity and mortality). M.: MNIOI im. P.A. Gertsena — filial FGBU «NMIC radiologii» Minzdrava Rossii; 2018. (In Russ.).
  4. Cancer Today — IARC. World Health Organization: GLOBOCAN; 2018. https://gco.iarc.fr/today/home
  5. Zhao J, Hu Y, Zhao Y, Chen D, Fang T, Ding M. Risk factors of endometrial cancer in patients with endometrial hyperplasia: implication for clinical treatments. BMC Womens Health. 2021;21:1:312.  https://doi.org/10.1186/s12905-021-01452-9
  6. Farghaly Samir A. Endometrial cancer: current epidemiology, detection and management. Nova Science Publishers, Inc; 2015.
  7. Bokhman YaV. Guide to gynecological oncology. M.: Kniga po trebovaniyu. 2012;464. (In Russ.).
  8. Kuznetsova IV. Endometrial hyperplastic processes. M. 2009;48. (In Russ.).
  9. Serov VN, Tikhomirov AL. Modern principles of therapy for inflammatory diseases of the female genital organs. Training aid. M. 2012. (In Russ.).
  10. Miles SM, Hardy BL, Merrell DS. Investigation of the microbiota of the reproductive tract in women undergoing a total hysterectomy and bilateral salpingo-oopherectomy. Fertil Steril. 2017;107:3:813-820.  https://doi.org/10.1016/j.fertnstert.2016.11.028
  11. Chiara Agostinis, Alessandro Mangogna, Fleur Bossi, Giuseppe Ricci, Uday Kishore, Roberta Bulla. Uterine immunity and microbiota: A shifting paradigm front. Immunol. 2019;17:10:2387. https://doi.org/10.3389/fimmu.2019.02387
  12. Nerea M Molina, Alberto Sola-Leyva, Maria Jose Saez-Lara, Julio Plaza-Diaz, Aleksandra Tubić-Pavlović, Barbara Romero, Ana Clavero, Juan Mozas-Moreno, Juan Fontes, Signe Altmäe. New opportunities for endometrial health by modifying uterine microbial composition: present or future? Biomolecules. 2020;11:10:4:593.  https://doi.org/10.3390/biom10040593
  13. Vitaly A Kushnir, Shirley Solouki Tal Sarig-Meth, Mario G Vega, David F Albertini, Sarah K Darmon, Liane Deligdisch, David H Barad, Norbert Gleicher. Systemic inflammation and autoimmunity in women with chronic endometritis. Am J Reprod Immunol. 2016;75:6:672-677.  https://doi.org/10.1111/aji.12508
  14. Novikova EG, Chulkova OV, Filatova YuV. Functionally sparing treatment of primary endometrial cancer in patients of reproductive age. Vestnik RONTS im. N.N. Blokhina RAMN. 2009;20:4:8-12. (In Russ.).
  15. Kachalina TS, Motovilova TM, Borovkova LV, Grechkanev GO, Ponomareva IV, Puchkova TN, Martyantseva IV, Zamyslova VP, Zinov’eva OS, Chikalova KI, Sirotina LZ. An integrative assessment of menstrual blood biomarkers in the diagnosis of non-neoplastic endometrial pathology. Akusherstvo i ginekologiya. 2019;3:121-126. (In Russ.). https://doi.org/10.18565/aig.2019.3.121-126
  16. Bishtavi AKh, Gornykh OA, Gulieva VN, Chikovani NG, Gogoladze KhT, Kostin AYu, Ivanov AE, Chabrov AM, Solopova AG, Tabakman YuYu, Manukhin IB. On the pathogenesis of endometrial hyperplasia. Opukholi zhenskoi reproduktivnoi sistemy. 2012;3-4:108-111. (In Russ.).
  17. Dumanovskaya MR, Chernukha GE, Asaturova AV, Kogan EA. The frequency of detection and structure of endometrial hyperplasia in different age periods. Akusherstvo i ginekologiya. 2015;3:40-44. (In Russ.).
  18. Management of Endometrial Hyperplasia. Green-top Guideline No. 67 RCOG/BSGE Joint Guideline. 2016. https://www.rcog.org.uk/globalassets/documents/guidelines/green-top-guidelines/gtg_67_endometrial_hyperplasia.pdf/
  19. Kotaro Kitaya, Takumi Takeuchi, Shimpei Mizuta, Hidehiko Matsubayashi, Tomomoto Ishikawa. Endometritis: new time, new concepts. Fertil Steril. 2018;110:3:344-350.  https://doi.org/10.1016/j.fertnstert.2018.04.012
  20. Petrov YuA, Kupina AD. Chronic endometritis: an old problem, new solutions. Vestnik SurGuMeditsina. 2020;4:46:18-23. (In Russ.).
  21. Song D, Feng X, Zhang Q, Xia E, Xiao Y, Xie W, Li TC. Prevalence and confounders of chronic endometritis in premenopausal women with abnormal bleeding or reproductive failure. Reprod Biomed Online. 2018;36:1:78-83.  https://doi.org/10.1016/j.rbmo.2017.09.008
  22. Radzinskii VE, Kiselev VI, Muizhinek EL, Ordiyants IM, Dobretsova TA. Chronic endometritis and fertility: newanswers. Status Praesens. Informatsionnyi byulleten’. 2016;18:76:5. (In Russ.).
  23. Radzinskii VE, Ipastova ID. Subclinical inflammatory deseases of the pelvic organs: from awareness of danger to program of action. Status Praesens. Informatsionnyi byulleten’. 2017;66. (In Russ.).
  24. Maybin JA, Critchley HO. Menstrual physiology: implications for endometrial pathology and beyond. Hum Reprod Update. 2015; 21:748-761.  https://doi.org/10.1093/humupd/dmv038
  25. Eremichev R, Kulebyakina M, Alexandrushkina N, Nimiritsky P, Basalova N, Grigorieva O, Egiazaryan M, Dyikanov D, Tkachuk V, Makarevich P. Scar-Free healing of endometrium: tissue-specific program of stromal cells and its induction by soluble factors produced after damage. Front Cell Dev Biol. 2021;9:616893. https://doi.org/10.3389/fcell.2021.616893
  26. Howard C, Rose CL, Trouton K, Stamm H, Marentette D, Kirkpatrick N, Karalic S, Fernandez R, Paget J. FLOW (finding lasting options for women): Multicentre randomized controlled trial comparing tampons with menstrual cups. Canadian Family Physician. 2011;57:6:208-215. 
  27. Donoso MB, Serra R, Rice GE, Gana MT, Rojas C, Khoury M, Arraztoa JA, Monteiro LJ, Acuña S, Illanes SE. Normality ranges of menstrual fluid. Volume during reproductive life using direct quantification of menses with vaginal cups. Gynecol Obstet Invest. 2019;84:4:390-395.  https://doi.org/10.1159/000496608
  28. North BB, Oldham MJ. Preclinical, clinical, and over-the-counter postmarketing experience with a new vaginal cup: menstrual collection. J Womens Health (Larchmt). 2011;20:303-311.  https://doi.org/10.1089/jwh.2009.1929
  29. Critchley HOD, Babayev E, Bulun SE, Clark S, Garcia-Grau I, Gregersen PK, Kilcoyne A, Kim J-YJ, Lavender M, Marsh EE, Matteson KA, Maybin JA, Metz CN, Moreno I, Silk K, Sommer M, Simon C, Tariyal R, Taylor HS, Wagner GP, Griffith LG. Menstruation: science and society. Am J Obstet Gynecol. 2020;223:5:624-664.  https://doi.org/10.1016/j.ajog.2020.06.004
  30. Devashana Gupta, M Louise Hull, Ian Fraser, Laura Miller, Patrick M M Bossuyt, Neil Johnson, Vicki Nisenblat. Endometrial biomarkers for the non-invasive diagnosis of endometriosis. Cochrane Database Syst. 2016;20:4:4:CD012165. https://doi.org/10.1002/14651858.CD012165
  31. Marina RS Walther-António, Jun Chen, Francesco Multinu, Alexis Hokenstad, Tammy J. Distad, E. Heidi Cheek, Gary L. Keeney, Douglas J. Creedon, Heidi Nelson, Andrea Mariani, Nicholas Chia.Potential contribution of the uterine microbiome in the development of endometrial cancer. Genome Med. 2016;25:8:1:122.  https://doi.org/10.1186/s13073-016-0368-y
  32. Petrov YuA, Alekhina AG, Blesmanovich AE. Actual nuances of the pathogenesis of chronic endometritis. Sovremennye problemy nauki i obrazovaniya. 2018;6:12-18. (In Russ.).
  33. Dobrokhotova YuE, Borovkova EI, Skal’naya VS, Borovkov IM. Chronic endometritis: the state of knowledge of the problem. Ginekologiya. 2019;21:49-52. (In Russ.).
  34. Elena Puente, Luis Alonso, Antonio Simone Laganà, Fabio Ghezzi, Jvan Casarin, Jose Carugno. Chronic Endometritis: Old Problem, Novel Insights and Future Challenges. Int J Fertil Steril. 2020;13:4:250-256.  https://doi.org/10.22074/ijfs.2020.5779
  35. Metlitskaya MA, Rogov YuI. Analysis of the incidence of human papillomavirus infection in endometrial hyperplastic processes and adenocarcinomas. Meditsinskie novosti. 2012;12:78-79. (In Russ.).
  36. Tapil’skaya NI, Gzgzyan AM, Kogan IYu. The hidden causes of reproductive failure. Viral infections in the development of chronic endometritis. Status Praesens. Akusherstvo, ginekologiya, besplodnyi brak. 2019;59:4:118-124. (In Russ.).
  37. Orazov MR, Radzinskii VE, Volkova SV, Khamoshina MB, Mikhaleva LM, Abitova MZ, Shustova VB. Chronic endometritis in women with endometriosis-associated infertility. Ginekologiya. 2020;22:3:15-20. (In Russ.).
  38. Unanyan AL, Sidorova IS, Kossovich YuM, Kogan EA, Demura TA. Chronic endometritis and HPV: disturbing news. The role of the combination of HPV infection and chronic endometritis in the pathogenesis of endometrial malignant tumors. Status Praesens. 2012;3:21-25. (In Russ.).
  39. Mal’tseva LI, Sharipova RI, Tsyplakov DE, Zhelezova ME. Morphofunctional state of the endometrium in women with bacterial-viral endometritis. Akusherstvo, ginekologiya. 2017;108:7:87-92. (In Russ.).
  40. Unanyan AL, Kossovich YuM, Demura TA, Baburin DV, Sidorova IS, Ishchenko AI. Clinical morphological features of chronic endometritis in women withinfertility. Arkhiv akusherstva i ginekologii im. V.F. Snegireva. 2017;4:4:208-213. (In Russ.).
  41. I Vassiliki Michou, Pantelis Constantoulakis, Kostantinos Makarounis, Giorgos Georgoulias, Vassilis Kapetanios, Vassilis Tsilivakos. Molecular investigation of menstrual tissue for the presence of Chlamydia trachomatis, Ureaplasma urealyticum and Mycoplasma hominis collected by women with a history of infertility. J Obstet Gynaecol. 2014;40;1:237-242.  https://doi.org/10.18821/2313-8726-2017-4-4-208-213
  42. Fani Gkrozou, Orestis Tsonis, Evangelos Dimitriou, Minas Paschopoulos. In women with chronic or subclinical endometritis is hysteroscopy suitable for setting the diagnosis? Asystematic review. Obstet Gynaecol. 2020;46:9:1639-1650. https://doi.org/10.1111/jog.14360
  43. Praderio RG, García Mitacek MC, Núñez Favre R, Rearte R, de la Sota RL, Stornelli MA. Uterine endometrial cytology, biopsy, bacteriology, and serum C-reactive protein in clinically healthy diestrus bitches. Theriogenology. 2019;131:153-161.  https://doi.org/10.1016/j.theriogenology.2019.03.039
  44. McFadyen JD, Zeller J, Potempa LA, Pietersz GA, Eisenhardt SU, Peter K. C-Reactive Protein and Its Structural Isoforms: An Evolutionary Conserved Marker and Central Player in Inflammatory Diseases and Beyond. Subcell Biochem. 2020;94:499-520.  https://doi.org/10.1007/978-3-030-41769-7_20
  45. Zoeva AR. Features of the diagnosis of chronic endometritis in patients of reproductive age. Materialy II Mezhdunarodnoi konferencii Prikaspiiskih gosudarstv. Astrahaskii gosudarstvennyi meditsinskii universitet. 2017;60-61. (In Russ.).
  46. Zarochentseva NV, Arshakyan AK, Men’shikova NS, Titchenko YuP. Chronic endometritis: etiology, clinical picture, diagnostics, treatment. Rossiiskii vestnik akushera-ginekologa. 2013;5:21-27. (In Russ.).
  47. Motovilova TM, Kachalina TS, Grechkanev GO, Borovkova LV, Zinov’ev AN, Nikolaeva OA, Ponomareva IV, Zamyslova VP, Puchkova TN, Stroikova KI, Gorkhelashvili LZ, Kozlova NA. Determination of biomarkers in menstrual blood as a possibility of non-invasive diagnosis of the inflammatory process in the uterine cavity. Meditsinskii al’manakh. 2016;5:88-91. (In Russ.).
  48. Tortorella C, Piazzolla G, Matteo M, Pinto V, Tinelli R, Sabbà C, Fanelli M, Cicinelli E. Interleukin-6, interleukin-1β, and tumor necrosis factor α in menstrual effluents as biomarkers of chronic endometritis. Fertil Steril. 2014;101:1:242-247.  https://doi.org/10.1016/j.fertnstert.2013.09.041
  49. Hosseini S, Udar F, Tohmi R, Sawadi-Shiraz E, Yeddi-Teherani M, Rahbari M, Zarnan AH. Menstrual blood contains immune cells with inflammatory and anti-inflammatory properties. J Obstet Gynaecol. 2015;41:11:1803-1812.
  50. Dobrokhotova YuE, Gankovskaya LV, Borovkova EI, Nugumanova OR. Exogenous cytokine therapy in the treatment of patients with chronic endometritis. Akusherstvo i ginekologiya. 2021;2:119-127. (In Russ.). https://doi.org/10.18565/aig.2021.2.119-126
  51. Hendrix J, Nijs J, Ickmans K, Godderis L, Ghosh M, Polli A. The Interplay between oxidative stress, exercise, and pain in health and disease: Potential role of autonomic regulation and epigenetic mechanisms. Antioxidants (Basel). 2020;23:9:11:1166. https://doi.org/10.3390/antiox9111166
  52. Dikareva LV, Shvarev EG, Ukhanova YuYu, Abzhalilova AR, Gviniashvili GG. Markers of menstrual discharge in the diagnosis of gynecological pathology. Eur J Natural History. 2013;2:7-10. 
  53. Ovodenko DL, Shvarev EG, Dikareva LV. Diagnostic value of identification of carbonyl groups of proteins in biological fluids of patients with ovarian tumors. Zhurnal akusherstva i zhenskikh boleznei. 2008;3:50-55. (In Russ.).
  54. Ordiyants IM, Kuular AA, Yamurzina AA, Guseinova RG, Novginov DS. Genetic and epigenetic mechanisms of endometrial hyperplasia in women of reproductive age. Akusherstvo i ginekologiya: novosti, mneniya, obuchenie. 2020;8:3:67-70. (In Russ.).
  55. Karapetyan OV, Fomochkina II, Zyablitskaya EYu, Kubyshkin VA, Kovalenko EP, Korobova PG, Makalish TP, Kubyshkin AV. The state of local markers of inflammation and apoptosis in the endometrium in hyperplasias of varying severity. Meditsinskii vestnik Severnogo Kavkaza. 2020;15:3:342-347. (In Russ.).
  56. Levakov SA, Sheshukova NA, Kedrova AG, Fedotova AS, Obukhova EA. Molecular biological profiles of endometrial hyperplasia and endometrial intraepithelial neoplasia. Opukholi zhenskoi reproduktivnoi sistemy. 2018;14:2:76-81. (In Russ.).
  57. Ukhanova YuYu, Dikareva LV, Shvarev EG, Ayupova AK. An integrated approach to the diagnosis of uterine fibroids and the assessment of the rate of its growth. Opukholi zhenskoi reproduktivnoi sistemy. 2015;11:4:71-75. (In Russ.).
  58. Shabalin VN, Shatokhina SN. Morphology of human biological fluids. M.: Hrizostom. 2001;304. (In Russ.).
  59. Koltovoi NA, Kraevoi SA. Diagnosis by a drop of blood. Crystallization of biofluids. Book 1. Crystallization of blood serum by the open drop method. M.: Bookwika.ru; 2014;248. (In Russ.).
  60. Koltovoi NA, Kraevoi SA. Crystallization of blood serum by the closed drop method (marginal dehydration). Book 2. Moscow—Smolensk: Elektronnyi matematicheskii i mediko-biologicheskii zhurnal «Matematicheskaya morfologiya»; 2016;20. (In Russ.).
  61. Feofilova MA, Tomareva EI, Evdokimova DV. Possibilities of crystallographic methods in the study of human pathology. Vestnik novykh meditsinskikh tekhnologii. 2017;24:4:198-208. (In Russ.).
  62. Dikareva LV, Shvariov EG. Complex diagnostics of myoendometrium pathology. European Journal of Natural History. 2008;1:83-86. 
  63. Shvarev EG, Ovodenko DL, Dikareva LV, Zaitseva OE. Morphostructural and biochemical features of biological fluids in patients with ovarian tumors. Astrakhanskii meditsinskii zhurnal. 2011;6:1:157-161. (In Russ.).
  64. Zoeva AR, Dikareva LV, Ukhanova YuYu, Tishkova OG, Sluvko NP, Ayupova AK. Morphostructural features of biological fluids with abnormal uterine bleeding. Vestnik Rossiiskogo universiteta druzhby narodov. Meditsina. 2016;2:92-97. (In Russ.).

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