New aspects of the pathogenesis of genitourinary syndrome of menopause

Grechkanev G.O.; Kotova T.V.; Raikova A.A.; Kachalina T.S.; Motovilova T.M.; Uglanova N.P.; Nikishov N.N.; Klemente Kh.M.

doi:https://doi.org/10.17116/rosakush20212106127

Grechkanev G.O.

Privolzhsky Research Medical University

Kotova T.V.

Russian State Social University

Raikova A.A.

Russian State Social University

Kachalina T.S.

Privolzhsky Research Medical University

Motovilova T.M.

Privolzhsky Research Medical University

Uglanova N.P.

Medical Center «Nika Spring Med»

Nikishov N.N.

Immanuel Kant Baltic Federal University

Klemente Kh.M.

Medical Center «Nika Spring Med»

New aspects of the pathogenesis of genitourinary syndrome of menopause

Authors:

Grechkanev G.O., Kotova T.V., Raikova A.A., Kachalina T.S., Motovilova T.M., Uglanova N.P., Nikishov N.N., Klemente Kh.M.

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Journal: Russian Bulletin of Obstetrician-Gynecologist. 2021;21(6): 27‑31

DOI: 10.17116/rosakush20212106127

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To cite this article:

Grechkanev GO, Kotova TV, Raikova AA, et al. . New aspects of the pathogenesis of genitourinary syndrome of menopause. Russian Bulletin of Obstetrician-Gynecologist. 2021;21(6):27‑31. (In Russ.)
https://doi.org/10.17116/rosakush20212106127

Подписка 2026 Российский вестник акушера-гинеколога (Russian Bulletin of Obstetrician-Gynecologist)

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INTRODUCTION

Genitourinary menopausal syndrome (GUMS) is becoming increasingly relevant due to the increase in the general population of peri- and postmenopausal women. The role of deprivation of the urogenital tract of estrogens in the pathogenesis of the disease is obvious and has been proven long ago. There are reasons to assume the participation of oxidative stress in the implementation of GUMS.

THE PURPOSE OF THE STUDY

To identify changes in the state of lipid peroxidation (LPO) and the antioxidant defense system (AODS) in patients with menopausal genitourinary syndrome.

MATERIAL AND METHODS

We examined 40 patients aged 48—52 years (mean age was 49.2±2.7 years) with a duration of menopause for 2.5±1.3 years, 20 of whom suffered from genitourinary syndrome (group I), another 20 patients (group II) had no manifestations of this disease. All patients underwent a study of lipoperoxidation by induced serum chemiluminescence, and the amount of primary (diene conjugates) and final (Schiff bases) molecular products of lipoperoxidation in the blood.

RESULTS AND DISCUSSION

The study of LPO by biochemiluminescence showed that in patients with GUMS (group I), Imax was higher than in women without GUMS by 1.6 times, S — by 1.63 times, and tg2-by 1.75 times (p<0.05 in all cases). The study of the content of molecular products of lipid peroxidation confirmed the findings of biochemiluminometer. The level of diene conjugates in patients of group I was 2.4 times higher than in women of group II, respectively, Schiff bases were 2.2 times higher in patients with GUMS (p<0.05 in both cases). It was also found that patients with GUMS were characterized by a catalase level of 1.38 times, and SOD was 1.29 times lower (p<0.05) compared to women of group II.

CONCLUSION

The obtained data testify about the role of peroxide stress in the pathogenesis of genitourinary menopausal syndrome, which requires appropriate correction.

Keywords:

genitourinary menopausal syndrome

lipid peroxidation

antioxidant protection

Authors:

Grechkanev G.O.

Privolzhsky Research Medical University

Kotova T.V.

Russian State Social University

Raikova A.A.

Russian State Social University

Kachalina T.S.

Privolzhsky Research Medical University

Motovilova T.M.

Privolzhsky Research Medical University

Uglanova N.P.

Medical Center «Nika Spring Med»

Nikishov N.N.

Immanuel Kant Baltic Federal University

Klemente Kh.M.

Medical Center «Nika Spring Med»

Received:

04.02.2021

Accepted:

22.03.2021

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