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Kosovtsova N.V.

FGBU "Ural'skiĭ nauchno-issledovatel'skiĭ institut okhrany materinstva i mladenchestva" Minzdrava Rossii, Ekaterinburg, Rossiia

Bashmakova N.V.

Ural Scientific Research Institute of Maternity and Child Health Ministry of the Russia, Yekaterinburg, Russia

Okulova E.O.

Ural Research Institute of Maternal and Infant Care, Yekaterinburg, Russia

Pavlichenko M.V.

Ural Research Institute of Maternal and Infant Care, Ministry of Health of Russia, Yekaterinburg, Russia

Markova T.V.

Ural Research Institute of Maternal and Infant Care, Ministry of Health of Russia, Yekaterinburg, Russia

Prenatal non-surgical treatments for pulmonary hypoplasia in congenital diaphragmatic hernia

Authors:

Kosovtsova N.V., Bashmakova N.V., Okulova E.O., Pavlichenko M.V., Markova T.V.

More about the authors

Journal: Russian Bulletin of Obstetrician-Gynecologist. 2019;19(1): 46‑53

DOI: 10.17116/rosakush20191901146

Read: 1509 times

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Table of contents

PRENATAL NON-SURGICAL TREATMENTS FOR PULMONARY HYPOPLASIA IN CONGENITAL DIAPHRAGMATIC HERNIA
PRENATAL NON-SURGICAL TREATMENTS FOR PULMONARY HYPOPLASIA IN CONGENITAL DIAPHRAGMATIC HERNIA

To cite this article:

Kosovtsova NV, Bashmakova NV, Okulova EO, Pavlichenko MV, Markova TV. Prenatal non-surgical treatments for pulmonary hypoplasia in congenital diaphragmatic hernia. Russian Bulletin of Obstetrician-Gynecologist. 2019;19(1):46‑53. (In Russ.)
https://doi.org/10.17116/rosakush20191901146

Подписка 2026 Российский вестник акушера-гинеколога (Russian Bulletin of Obstetrician-Gynecologist)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

This review is devoted to the problem of prenatal noninvasive therapy for lethal pulmonary hypoplasia in congenital diaphragmatic hernia. Despite significant progress in neonatal resuscitation and intensive care, the morbidity and mortality rates due to this pathology remain high. The only current technique for the prenatal correction of pulmonary hypoplasia, such as fetoscopic tracheal balloon occlusion, is invasive, time-consuming, and also carries a risk for a lot of possible complications, so there is a search for alternative prenatal strategies. This review presents the currently available experimental approaches, which are based on the use of different drug groups and stem cells, to the drug correction of lethal fetal pulmonary hypoplasia in congenital diaphragmatic hernia. These techniques have been mainly used on animal models of congenital diaphragmatic hernia with secondary lethal hypoplasia. Different approaches (surgically created lamb and rabbit models and a teratogen-induced model that has been described in rats and mice) have been applied to ensure congenital diaphragmatic hernia formation in animals. To switch to the drug correction of congenital diaphragmatic hernia in clinical practice is sure to call for further investigations in this area.

Keywords:

congenital diaphragmatic hernia
pulmonary hypoplasia
stem cells
prenatal drug therapy

Authors:

Kosovtsova N.V.

FGBU "Ural'skiĭ nauchno-issledovatel'skiĭ institut okhrany materinstva i mladenchestva" Minzdrava Rossii, Ekaterinburg, Rossiia

Bashmakova N.V.

Ural Scientific Research Institute of Maternity and Child Health Ministry of the Russia, Yekaterinburg, Russia

Okulova E.O.

Ural Research Institute of Maternal and Infant Care, Yekaterinburg, Russia

Pavlichenko M.V.

Ural Research Institute of Maternal and Infant Care, Ministry of Health of Russia, Yekaterinburg, Russia

Markova T.V.

Ural Research Institute of Maternal and Infant Care, Ministry of Health of Russia, Yekaterinburg, Russia

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