Objective. To evaluate the efficiency of a treatment option in infertile patients with endometrial hypoplasia due to chronic endometritis, by irrigating the endometrium with a drug exposed to low-frequency ultrasound. Subject and methods. Fifty-nine women, diagnosed with first- or second-degree infertility and endometrial hypoplasia in the presence of chronic endometritis, were examined. The patients from a study group (n=32) received conventional therapy for chronic endometritis and uterine wall irrigation with a 0.05% chlorhexidine solution or an immunomodulatory solution in a sterile isotonic sodium chloride solution in a ratio of 1:50, which had been exposed to low-frequency sound according to our chosen scheme. Those from a comparison group (n=27) had conventional therapy for chronic endometritis. The diagnosis of the latter was histologically verified in 100% of cases in both groups. Drug solutions were exposed to ultrasound using a Photek AK 100-25 ultrasound apparatus. An ultrasound scanner was employed to assess results from changes in M-mode echo dimensions. Results. In the comparison group, M-mode echo dimensions increased a month after treatment initiation, but during further treatment remained at the same level and did not exceed 6.9 mm. After the second and third treatment cycles, the study group showed a significant increase in M-mode echo; the mean endometrial thickness was 8.4 mm; there was a 52±0.12% rise in M-mode echo dimension. Histological examination in the study group revealed no signs of chronic endometritis in any case after treatment; 11 pregnancies occurred. Conclusion. Endometrial irrigation with a drug solution exposed to low-frequency ultrasonic vibrations as part of conventional therapy in infertile patients with endometrial hypoplasia due to chronic endometritis corresponds to adequate endometrial growth in the proliferation phase and to creation of favorable conditions for ovum implantation.