The specific features of T-cell immunoregulation in miscarriage: Paradigm evolution

Makarkov A.I.; Buianova S.N.; Ivanova O.G.; Linnik A.P.

doi:https://doi.org/

Makarkov A.I.

Rodil'nyĭ dom #3, Moskva

Buianova S.N.

Moskovskiĭ oblastnoĭ NII akusherstva i ginekologii

Ivanova O.G.

Rodil'nyĭ dom #3, Moskva

Linnik A.P.

Rodil'nyĭ dom #3, Moskva

The specific features of T-cell immunoregulation in miscarriage: Paradigm evolution

Authors:

Makarkov A.I., Buianova S.N., Ivanova O.G., Linnik A.P.

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Journal: Russian Bulletin of Obstetrician-Gynecologist. 2012;12(5): 10‑16

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To cite this article:

Makarkov AI, Buianova SN, Ivanova OG, Linnik AP. The specific features of T-cell immunoregulation in miscarriage: Paradigm evolution. Russian Bulletin of Obstetrician-Gynecologist. 2012;12(5):10‑16. (In Russ.)

Подписка 2026 Российский вестник акушера-гинеколога (Russian Bulletin of Obstetrician-Gynecologist)

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Abstract:

Pregnancy with a favorable outcome is a unique immunological phenomenon that suggests, among other factors, a shift in the balance of effector CD4+ T-helper lymphocytes, known as Th1 and Th2, and a preponderance of a Th2 subpopulation. Recent studies have shown the limitations of the classical Th1/Th2 paradigm that is complemented by a description of the value of regulatory T lymphocytes (Treg) and Th17-mediated mechanisms. This review deals with the characteristics of differentiation factors, key cytokines, and transcription factors, as well as the role of Th1, Th2, Th17, and Treg cells in the physiological and pathological variants of an immune interaction between the mother and the fetus. It demonstrates the need for further investigation of the implication of interleukin-17 and Th17 cells in the pathogenesis of miscarriage.

Keywords:

miscarriage

type 1 T-helper cells

type 2 T-helper cells

type 17 T-helper cells

regulatory T-lymphocytes

Authors:

Makarkov A.I.

Rodil'nyĭ dom #3, Moskva

Buianova S.N.

Moskovskiĭ oblastnoĭ NII akusherstva i ginekologii

Ivanova O.G.

Rodil'nyĭ dom #3, Moskva

Linnik A.P.

Rodil'nyĭ dom #3, Moskva

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References:

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