Advanced Therapy of Allergic Rhinitis: Possibilities, Limitations and Prospects

Nosulya E.V.; Kim I.A.; Kunelskaya V.Ya.; Luchsheva Yu.V.

doi:https://doi.org/10.17116/rosrino20233101154

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STUDY OBJECTIVE

Data analysis and summary of possibilities and limitations of advanced options for AR therapy

MATERIALS AND METHODS

Analysis of PubMed publications (articles and corresponding abstracts) was performed. The information was chosen according to the following keywords: fixed combinations, olopatadine, mometasone furoate, levocetirizine, montelukast, control of allergic rhinitis symptoms.

RESULTS

Most of patients with AR who seek medical care have moderate/severe symptoms. Monotherapy inefficiency in the majority of patients with AR, the need for polytherapy, changes in the number of prescriptions during treatment demonstrate the advisability of searching for new approaches in AR treatment.

CONCLUSION

One of the preferred strategies in AR treatment is the use of fixed dose combinations, either in the form of a nasal spray (olopatadine hydrochloride + mometasone furoate) or in tablet form (levocetirizine dihydrochloride + sodium montelukast), which avoid polypragmasia and provide faster and more complete control of AR symptoms than current first-line monotherapy.

Keywords:

fixed combinations

olopatadine

mometasone furoate

levocetirizine

montelukast

control of allergic rhinitis symptoms

Authors:

Nosulya E.V.

Sverzhevky Research Clinical Institute of Otorhinolaryngology

ORCID: 0000-0002-3897-8384

Kim I.A.

N.I. Pirogov Russian National Research Medical University;
National Medical Research Center of Otorhinolaryngology of Federal Medical-Biological Agency

ORCID: 0000-0003-1078-6388

Kunelskaya V.Ya.

L.I. Sverzhevskiy Research Institute of Clinical Otorhinolaryngology

ORCID: 0000-0001-5640-6833

Luchsheva Yu.V.

Sverzhevsky Research Clinical Institute of Otorhinolaryngology

ORCID: 0000-0002-8412-710X

Received:

10.01.2023

Accepted:

11.01.2023

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References:

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