Skin cancer is one of the most widespread neoplasms of the head and neck usually localized at the external nose and in the buccal region. The extensive forms of basal cell cancer require treatment with the surgical intervention. Both local and transposed tissues are usually used for the purpose of reconstructive surgery. The extensive defects need to be corrected with the use of the combined skin grafting techniques. The present article was designed to report our own experience with the application of the combined plastic reconstruction method for the treatment of basal cell cancer of the skin. Patient L., aged 52 years, presented with the diagnosis of skin cancer of the left wing of the nose, T4N0M0. The analysis of the patient’s medical history showed that she had the disease during almost two years. The biopsy study of the left nasal alar was first carried out in a local medical setting (the medical assessment report №14447-49: hair follicle nevus in papilloma). The biopsy study was repeated based at the Research and Clinical Centre of Otorhinolaryngology, Federal Medico-Biological Agency of the Russian Federation (the histological assessment report №960/15: basal cell cancer). The following tumour characteristics were documented in the course of the objective examination: the infiltrative-ulcerative growth, destruction of the left wing of the nose extending to the nasal dorsum, the angle of the left eye, and the left-hand side of the vestibule of the nose up to the anterior edge of the inferior turbinated bone. The tumour was painful and bleeding in response to probing. The patient underwent the surgical intervention that included removal of the neoplasm with the simultaneous reconstruction of the affected eyelid, covering of the defect in the buccal region, and the correction of the external nose defect. Based on the results of the histological assessment report №32-40/16: 1, the removed neoplasm was characterized as basal cell cancer with no signs of the tumour growth at the resection margins. The immediate postoperative period was uneventful. The long-term follow up observation of the patient revealed extensive granulations and retraction of the rostral edge of the flap within 3 months after surgery. Thereafter, the patient was given the remedial treatment including the dissection of the granulation tissue in the vestibule of the nose with the use of a CO2-laser and the implantation of a polytetrafluroethylene-based non-biological graft into the bulk of the flap with the purpose of shaping the rigid left wing of the nose. The patient was discharged from the clinic in a satisfactory condition within 7 days after the treatment; she reported an appreciable improvement of nasal breathing. Patient N., aged 78 years presented with a relapse of basal cell cancer of the nasal skin that developed after the surgical treatment. The objective observations revealed infiltration of the recurring neoplasm throughout the entire thickness of the skin in the previously operated region and its extension to the medial angle of the eye and the nasobuccal fold. The patient was given the surgical treatment by the method described in the first clinical case. At present, the patient is under active dynamic observation. The closure of the defect in the forehead region is planned with the application of the full-thickness flap to be harvested from the frontal and parietal regions by means of the free skin grafting technique. Conclusion. The treatment of extensive basal cell skin cancer is most frequently performed by means of the surgical intervention with simultaneous reconstruction of the intraoperative defect. We usually resort to the plastic correction by mobilizing the local tissues and/or transposing a pedunculated flap as swell as the free or combined grafting methods. The use of a full-thickness forehead flap is fraught with the risk of an additional trauma and sometimes fails to produce the desired cosmetic outcome. At the same time, this approach allows the nose respiration to be recovered and remains the method of choice in certain cases of the treatment of skin cancer of the external nose.