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Nagatkina O.V.

I.M. Sechenov First Moscow State Medical University (Sechenov University);
National Research Tomsk Polytechnic University

Sokolova E.S.

I.M. Sechenov First Moscow State Medical University (Sechenov University);
National Research Tomsk Polytechnic University

Suvorova O.A.

I.M. Sechenov First Moscow State Medical University (Sechenov University);
National Research Tomsk Polytechnic University

Antonov D.V.

National Research Tomsk Polytechnic University

Technological evolution of inhalers: intelligent systems and controlled delivery to the respiratory tract

Authors:

Nagatkina O.V., Sokolova E.S., Suvorova O.A., Antonov D.V.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2025;28(8): 115‑122

DOI: 10.17116/profmed202528081115

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Table of contents

TECHNOLOGICAL EVOLUTION OF INHALERS: INTELLIGENT SYSTEMS AND CONTROLLED DELIVERY TO THE RESPIRATORY TRACT
TECHNOLOGICAL EVOLUTION OF INHALERS: INTELLIGENT SYSTEMS AND CONTROLLED DELIVERY TO THE RESPIRATORY TRACT

To cite this article:

Nagatkina OV, Sokolova ES, Suvorova OA, Antonov DV. Technological evolution of inhalers: intelligent systems and controlled delivery to the respiratory tract. Russian Journal of Preventive Medicine. 2025;28(8):115‑122. (In Russ.)
https://doi.org/10.17116/profmed202528081115

 
Подписка 2026 Профилактическая медицина (Russian Journal of Preventive Medicine)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Inhalation therapy is the most common treatment for respiratory diseases. Its effectiveness depends on several factors, including the therapeutic properties of aerosols, the design of inhalers (dispensers), and the correct inhalation technique, all of which affect the expected treatment results. Therefore, it is crucial to develop innovative solutions that optimize the delivery of inhaled products (IPs) to the lungs, thereby ensuring the effectiveness of therapy.

OBJECTIVE

To analyze the innovative and promising technologies used in inhaled product delivery devices described in Russian and international publications, considering their physical and technological properties, and the potential for distribution in the lungs (deposition) in the treatment of respiratory diseases.

MATERIALS AND METHODS

We reviewed the publications available in the international scientific citation databases eLibrary, Web of Science, Scopus, and PubMed. The analysis included studies on advancements and prospects in the development of devices for the targeted delivery of IDs, as well as physical principles, advantages, and disadvantages of these devices. When searching for publications, individual keywords or their combinations were used, including inhaled products, inhalers, aerosols, targeted delivery technology, respiratory tract diseases, and chronic obstructive pulmonary diseases.

RESULTS

The literature review showed several promising innovative technologies used in the targeted delivery of inhaled products, including «smart» inhalers and digital technologies. It opens up opportunities for monitoring the use of appropriate devices and personalized therapy. Such innovative opportunities include the controlled release of inhaled products and their targeted delivery, which increases the accuracy, effectiveness, and personalization of inhalation therapy.

CONCLUSION

The widespread use of «smart» inhalers in clinical practice supports further interdisciplinary research aimed at integrating modern technological developments with the individual characteristics of patients and specific clinical tasks.

Keywords:

inhaled products
inhaler
aerosols
targeted delivery technology
respiratory diseases
chronic obstructive pulmonary diseases

Authors:

Nagatkina O.V.

I.M. Sechenov First Moscow State Medical University (Sechenov University);
National Research Tomsk Polytechnic University

Sokolova E.S.

I.M. Sechenov First Moscow State Medical University (Sechenov University);
National Research Tomsk Polytechnic University

Suvorova O.A.

I.M. Sechenov First Moscow State Medical University (Sechenov University);
National Research Tomsk Polytechnic University

Antonov D.V.

National Research Tomsk Polytechnic University

Received:

06.06.2025

Accepted:

20.06.2025

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