Modern treatment of bronchopulmonary pathology is inextricably connected with the inhalation drug delivery. Despite the diversity of drug delivery devices, achievement of their effective distribution in the lungs still requires additional efforts. In this connection, the development of new approaches to optimize the pulmonary deposition of orally inhaled drugs seems relevant.
OBJECTIVE
To analyze the modern orally inhaled drugs used in the treatment of bronchopulmonary diseases, considering their pharmacological and physical properties, the distribution features in the respiratory tract depending on the delivery systems and in the context of the search for approaches, perfecting their pulmonary deposition.
MATERIAL AND METHODS
The review was performed using publications available in international scientific citation databases: eLibrary, Web of Science, Scopus, PubMed. The analysis included studies on the targeted delivery of different groups of orally inhaled drugs according to their molecular composition, delivery devices, thermophysical and hydrodynamical features when moving along the respiratory tract.
RESULTS
The analysis of foreign and domestic experience has shown that the success of respiratory medicine towards targeted delivery of drugs contributes to improvement of the treatment effectiveness and prevention of exacerbations of chronic respiratory pathology. The studies have shown that in inhalation therapy, despite the diversity of drugs, the appearance of their new combinations and improvement of delivery devices, the problem of achieving stable and effective regulation of aerosol deposition in the lower respiratory tract remains unresolved.
CONCLUSION
The available in literature data confirm that further optimization of the targeted delivery of orally inhaled drugs requires a more detailed analysis of their physical properties and aerosol spraying mechanisms.