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Nagatkina O.V.

Sechenov First Moscow State Medical University (Sechenov University)

Sokolova E.S.

Sechenov First Moscow State Medical University (Sechenov University)

Suvorova O.A.

Sechenov First Moscow State Medical University (Sechenov University)

Antonov D.V.

National Research Tomsk Polytechnic University

Features of modern inhalation therapy and topical aerosol delivery

Authors:

Nagatkina O.V., Sokolova E.S., Suvorova O.A., Antonov D.V.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2024;27(11): 122‑128

DOI: 10.17116/profmed202427111122

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Table of contents

FEATURES OF MODERN INHALATION THERAPY AND TOPICAL AEROSOL DELIVERY
FEATURES OF MODERN INHALATION THERAPY AND TOPICAL AEROSOL DELIVERY

To cite this article:

Nagatkina OV, Sokolova ES, Suvorova OA, Antonov DV. Features of modern inhalation therapy and topical aerosol delivery. Russian Journal of Preventive Medicine. 2024;27(11):122‑128. (In Russ.)
https://doi.org/10.17116/profmed202427111122

 
Подписка 2026 Профилактическая медицина (Russian Journal of Preventive Medicine)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
Recommended articles:
Technological evolution of inha­lers: inte­lligent systems and controlled deli­very to the respiratory tract. Russian Journal of Preventive Medi­cine. 2025;(8):115-122
Abstract:

Modern treatment of bronchopulmonary pathology is inextricably connected with the inhalation drug delivery. Despite the diversity of drug delivery devices, achievement of their effective distribution in the lungs still requires additional efforts. In this connection, the development of new approaches to optimize the pulmonary deposition of orally inhaled drugs seems relevant.

OBJECTIVE

To analyze the modern orally inhaled drugs used in the treatment of bronchopulmonary diseases, considering their pharmacological and physical properties, the distribution features in the respiratory tract depending on the delivery systems and in the context of the search for approaches, perfecting their pulmonary deposition.

MATERIAL AND METHODS

The review was performed using publications available in international scientific citation databases: eLibrary, Web of Science, Scopus, PubMed. The analysis included studies on the targeted delivery of different groups of orally inhaled drugs according to their molecular composition, delivery devices, thermophysical and hydrodynamical features when moving along the respiratory tract.

RESULTS

The analysis of foreign and domestic experience has shown that the success of respiratory medicine towards targeted delivery of drugs contributes to improvement of the treatment effectiveness and prevention of exacerbations of chronic respiratory pathology. The studies have shown that in inhalation therapy, despite the diversity of drugs, the appearance of their new combinations and improvement of delivery devices, the problem of achieving stable and effective regulation of aerosol deposition in the lower respiratory tract remains unresolved.

CONCLUSION

The available in literature data confirm that further optimization of the targeted delivery of orally inhaled drugs requires a more detailed analysis of their physical properties and aerosol spraying mechanisms.

Keywords:

inhalers
aerosols
targeted delivery
deposition

Authors:

Nagatkina O.V.

Sechenov First Moscow State Medical University (Sechenov University)

Sokolova E.S.

Sechenov First Moscow State Medical University (Sechenov University)

Suvorova O.A.

Sechenov First Moscow State Medical University (Sechenov University)

Antonov D.V.

National Research Tomsk Polytechnic University

Received:

04.09.2024

Accepted:

09.09.2024

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