Influence of smoking status on vascular permeability and microcirculation in healthy young individuals, middle-age patients with arterial hypertension and coronary artery disease

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OBJECTIVE

To assess the influence of smoking and smoking cessation on the parameters of vascular permeability and microhemorheology in young, healthy individuals and middle-aged patients with hypertension and coronary artery disease.

MATERIALS AND METHODS

The overall database (n=267, subjects with different smoking status) was analyzed, in which information about the age and assignment of the patient to a particular group was initially hidden. The study included healthy young people (n=80), patients with primary hypertension (n=95), and middle-aged patients with CAD (n=92). In the statistical procedure, only the microcirculation parameters obtained by videobiomicroscopy of the bulbar conjunctiva were considered. Cluster analysis was used to identify natural groupings of observations.

RESULTS

During cluster analysis, all observations were divided into two clusters. Cluster 1 included all young non-smokers (18.8%) and those who stopped smoking (22.7%), the majority of non-smokers (17%) and those who stopped smoking with hypertension (11%). Cluster 2 included patients with coronary artery disease (66.3%) and the majority of smokers with hypertension (16%). In subjects included in cluster 2, the parameters of vascular permeability and microhaemorheology were significantly abnormally changed in comparison with the parameters in subjects included in cluster 1 (p<0.0001).

CONCLUSIONS

1. At a young age, in subjects without chronic diseases, normal endothelial function compensates for the adverse effects of smoking. 2. In patients with unstable coronary heart disease, significant alterations of the parameters of vascular permeability and microhemorheology are due to the age of patients and acute coronary disease; smoking is not a key factor affecting changes in microcirculation. 3. In young and middle-aged patients with grade I and II hypertension, smoking significantly alters the microcirculation, and smoking cessation has a pronounced beneficial effect.

Keywords:

microcirculation

microcirculatory system

smoking

smoking cessation

vascular permeability

intravascular aggregation of erythrocytes

microhaemorheology

Authors:

Korneeva N.V.

Far-Eastern State Medical University

ORCID: 0000-0001-9878-180X

Received:

23.05.2023

Accepted:

25.09.2023

List of references:

Suskin N, Sheth T, Negassa A, Yusuf S. Relationship of current and past smoking to mortality and morbidity in patients with left ventricular dysfunction. Journal of the American College of Cardiology. 2001;37(6):1677-1682. https://doi.org/10.1016/s0735-1097(01)01195-0
Ostroumova OD, Kopchjonov II, Guseva TF. Smoking as a Risk Factor for Cardiovascular and Cerebrovascular Diseases: Prevalence, Impact on Prognosis, Possible Smoking Cessation Strategies and their Effectiveness. Part 2. Advantages of Quitting Smoking. Strategies to Quit Smoking. Racional’naja farmakoterapija v kardiologii. 2018;14(1):111-121. (In Russ.). https://doi.org/10.20996/1819-6446-2018-14-1-111-121
Khaltourina DA, Zamiatnina E, Zubkova TS. The impact of smoking on mortality in russia in 2019. Demograficheskoe obozrenie. 2021;8(1):81-105. (In Russ.).
Gorshkov AYu, Boytsov SA. Endothelial glycocalyx — potential vascular biomarker: diagnostic and therapeutic target in cardiovascular diseases. Kardiovaskuljarnaja Terapija I Profilaktika. 2015;14(6):87-92. (In Russ.). https://doi.org/10.15829/1728-8800-2015-6-87-92
Podzolkov VI, Bragina AE, Druzhinina NA. Relation of smoking and endothelial dysfunction markers in systemic hypertension. Kardiovaskuljarnaja terapija i profilaktika. 2018;17(5):11-16. (In Russ.). https://doi.org/10.15829/1728-8800-2018-5-11-16
Sirotin BZ, Korneeva NV. Vascular permeability and intravascular erythrocyte aggregation in young people after smoking cessation. Terapevticheskii arkhiv. 2017;89(4):35-38. (In Russ.). https://doi.org/10.17116/terarkh201789435-38
Korneeva NV, Sirotin BZ. Mikrocirkuljatornoe ruslo u ranee kurivshih pacientov s arterial’noj gipertenziej. Lechashhij vrach. 2019;2:6-10. (In Russ.).
Korneeva NV. Microcirculation and vascular permeability in ex-smokers with coronary heart disease. Profilakticheskaja medicina. 2017;20(6):62-67. (In Russ.). https://doi.org/10.17116/profmed201720662-67
Korneeva NV, Leonov VP, Zhmerenetsky KV. Conjunctival biomicroscopy: methodology of analysis. Khabarovsk: FESMU publishing; 2020. (In Russ.).
Lang TA, Sesik M. Kak opisy`vat` statistiku v medicine. Rukovodstvo dlya avtorov, redaktorov i recenzentov. Per. c angl. pod red. Leonova VP. M.: Prakticheskaya Medicina; 2011. (In Russ.). https://doi.org/10.1097/00006205-199705000-00022
Korneeva NV, Sirotin BZ. Sposob ocenki rasprostranennosti vnutrisosudistoj agregacii jeritrocitov u cheloveka in vivo. Patent RF na izobretenie №2613082/15.03.2017. Bjul. №8. Accessed May 17, 2023. (In Russ.). https://i.moscow/patents/ru2613082c1_20170315
Rossi M, Cupisti A, Mariano’s. Endothelium-dependent and endothelium independent skin vasoreactivity in the elderly. Aging Clinical and Experimental Research. 2002;14(5):343-346. https://doi.org/10.1007/BF03324460
Musikhina NA, Petelina TI, Gapon LI, Kostousova AI. Blood pressure variability, endothelial dysfunction, and C-reactive protein levels in arterial hypertension in combination with coronary artery disease. Sistemnye gipertenzii. 2021;18(4):165-168. (In Russ.).
Pronko TP, Snezhitskiy VA, Shulika VR. Endothelial dysfunction, systemic inflammation, platelet aggregation properties and their relationship in patients with stable stenocardia. Regionarnoe krovoobrashhenie i mikrocirkuljacija. 2020;19(1):22-28. (In Russ.). https://doi.org/10.24884/1682-6655-2020-19-1-22-28
Streltsova NN, Vasiliev AP. The influence of smoking on the functional state of microcirculation according to laser doppler flowmetry and clinical anamnestic data of patients with arterial hypertension. Lazernaja medicina. 2020; 24(4):24-31. (In Russ.). https://doi.org/10.37895/2071-8004-2020-24-4-24-31

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