The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Molchanova O.V.

FGBU "GNITs profilakticheskoĭ meditsiny" Minzdrava RF, Moskva

Britov A.N.

Gosudarstvennyĭ nauchno-issledovatel'skiĭ tsentr profilakticheskoĭ meditsiny Minzdravsotsrazvitiia RF, Moskva

Platonova E.V.

FGBU "Gosudarstvennyĭ nauchno-issledovatel'skiĭ tsentr profilakticheskoĭ meditsiny" Minzdrava Rossii

Importance of elevated uric acid levels in the development and prevention of chronic non-communicable diseases

Authors:

Molchanova O.V., Britov A.N., Platonova E.V.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2020;23(2): 102‑108

DOI: 10.17116/profmed202023021102

Read: 136270 times

Download PDF (RU)
Contact the author
Table of contents

IMPORTANCE OF ELEVATED URIC ACID LEVELS IN THE DEVELOPMENT AND PREVENTION OF CHRONIC NON-COMMUNICABLE DISEASES
IMPORTANCE OF ELEVATED URIC ACID LEVELS IN THE DEVELOPMENT AND PREVENTION OF CHRONIC NON-COMMUNICABLE DISEASES

To cite this article:

Molchanova OV, Britov AN, Platonova EV. Importance of elevated uric acid levels in the development and prevention of chronic non-communicable diseases. Russian Journal of Preventive Medicine. 2020;23(2):102‑108. (In Russ.)
https://doi.org/10.17116/profmed202023021102

Подписка 2026 Профилактическая медицина (Russian Journal of Preventive Medicine)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Study of opinions of medi­cal students on medi­cal prevention issues. Russian Journal of Preventive Medi­cine. 2024;(12):69-74
Problems of regu­lar medi­cal check-up orga­nization of young males aged 15—17 years with cardiometabolic diseases. Russian Journal of Preventive Medi­cine. 2024;(12):81-87
Asse­ssment of risk of deve­loping fractures and sarcopenia and quality of life of patients with chro­nic kidney disease at the outpatient stage. Russian Journal of Preventive Medi­cine. 2024;(12):88-91
The role of quantitative body composition analysis in popu­lation in the asse­ssment and moni­toring of cardiovascular risk meta­bolic factors. Russian Journal of Preventive Medi­cine. 2024;(12):128-134
Gastric cancer: inci­dence, risk factors, screening. Russian Journal of Preventive Medi­cine. 2024;(12):135-139
Intracranial hype­rtension in hemo­rrhagic stroke: a single-center retrospective study. Russian Journal of Anesthesiology and Reanimatology. 2024;(6):23-29
COVID-19 and pneumonia — mortality and coding features (example of the Moscow region). Medi­cal Technologies. Asse­ssment and Choice. 2024;(4):30-39
Stru­ctural and functional features of the main arte­ries of the brain and tumor necrosis factor-alpha in people with chro­nic non-infectious diseases. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11):178-184
The rela­tionship of diet and nutrition with the frequency of migraine atta­cks. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12):30-35
Clinical and epidemiological indi­cators of stroke during the COVID-19 pandemic and in the post-COVID period in the Moscow region. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12-2):5-11
Abstract:

A growing body of evidence indicates that there is a relationship between hyperuricemia and various chronic non-communicable diseases (gout, obesity and cardiovascular diseases, such as hypertension, coronary heart disease, heart failure, and atrial fibrillation). Most studies deal with the relationship between elevated uric acid (UA) levels and cardiovascular morbidity and mortality. It is currently unclear whether an elevated UA level is a cause, a sequel, or simply a factor accompanying cardiovascular disease, since the higher level of UA is frequently associated with the already existing cardiovascular risk factors. Understanding the clinical significance of this relationship may allow the control of UA levels to be started as early as possible in order to prevent the diseases in patients with hyperuricemia and possibly to identify a special group of people at high risk for chronic non-communicable (including cardiovascular) diseases for a follow-up and preventive counseling.

Keywords:

uric acid
chronic non-communicable diseases
mortality
prevention
follow-up

Authors:

Molchanova O.V.

FGBU "GNITs profilakticheskoĭ meditsiny" Minzdrava RF, Moskva

Britov A.N.

Gosudarstvennyĭ nauchno-issledovatel'skiĭ tsentr profilakticheskoĭ meditsiny Minzdravsotsrazvitiia RF, Moskva

Platonova E.V.

FGBU "Gosudarstvennyĭ nauchno-issledovatel'skiĭ tsentr profilakticheskoĭ meditsiny" Minzdrava Rossii

Close metadata

References:

  1. De Becker B., Borghi C., Burnier M., van de Borne P. Uric acid and hypertension: a focused review and practical recommendations. J Hypertens. 2019;37(5):878-883. https://doi.org/10.1097/HJH.0000000000001980
  2. Ruggiero С., et al. Uric acid and inflammatory markers. Euro Heart J. 2006;27:1174-1181. https://doi.org/10.1093/eurheartj/ehi879
  3. Culleton B.F., Larson M.G., Kannel W.B., Levy D. Serum Uric Acid and Risk for Cardiovascular Disease and Death: The Framingham Heart Study. Ann Intern Med. 1999;131:7-13. https://doi.org/10.7326/0003-4819-131-1-199907060-00003
  4. Feig D.I., Kang D.H., Johnson R.J. Uric acid and cardiovascular risk. N Engl J Med. 2008;359(17):1811-1821. https://doi.org/10.1056/NEJMra0800885
  5. Georg J., Carr E., Davies J., et al. High-dose allopurinol improves endothelial function by profoundly reducing vascular oxidative stress and not by lowering uric acid. Circulation. 2006;114: 2508-2516. https://doi.org/10.1161/CIRCULATIONAHA.106.651117
  6. Nielsen S.M., et al. Weit loss for overweit and individuals with gout: a systematic review of longitudinal studies. Ann Rheum Dis. 2017;76:1870-1882. https://doi.org/10.1136/annrheumdis-2017-211472
  7. Rathmann W., Haastert B., Icks A., et al. Ten-year change in serum uric acid and its relation to changes in other metabolic risk factors in young black and white adults: the CARDIA study. Eur J Epidemiol. 2007;22:439-445. https://doi.org/10.1007/s10654-007-9132-3
  8. Tanaka K., Ogata S., Tanaka H., et al. Osaka Twin Research Group, Hayakawa K. The relationship between body mass index and uric acid: a study on Japanese adult twins. Environ Health Prev Med. 2015;(20):347-353. https://doi.org/10.1007/s12199-015-0473-3
  9. Fang J., Alderman M.H. Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971—1992. National Health and Nutrition Examination Survey. JAMA. 2000;283(18):2404-2410. https://doi.org/10.1001/jama.283.18.2404
  10. Palmer T.M., et al. Assosiation of plasma uric acid with ischaemic heart disease and blood pressure: mendelian randomization analysis of two large cohort. BMJ. 2013;347:f4262. https://doi.org/10.1136/bmj.f4262
  11. Franse L.V., Pahor M., Di Bari M., et al. Serum uric acid, diuretic treatment and risk of cardiovascular events in the Systolic Hypertension in the Elderly Program (SHEP). J Hypertens. 2000;18(8):1149-1154. PMID:10954008
  12. Holme I., Aastveit A.H., Hammar N., et al. Uric acid and risk of myocardial infarction, stroke and congestive heart failure in 417,734 men and women in the Apolipoprotein MOrtality RISk study (AMORIS). J Intern Med. 2009;266(6):558-570. https://doi.org/10.1111/j.1365-2796.2009.02133.x
  13. Strasak A.M., Kelleher C.C., Brant L.J., et al. VHM&PP Study Group. Serum uric acid is an independent predictor for all major forms of cardiovascular death in 28,613 elderly women: a prospective 21-year follow-up study. Int J Cardiol. 2008;125(2):232-239. https://doi.org/10.1016/j.ijcard.2007.11.094
  14. Storhaug HM, Norvik JV, Toft I, et al. Uric acid is a risk factor for ischemic stroke and all-cause mortality in the general population: a gender specific analysis from The Tromsø Study. BMC Cardiovasc Disord. 2013;13:115. https://doi.org/10.1186/1471-2261-13-115
  15. Chang C.C., Wu C.H., Liu L.K., et al. Association between serum uric acid and cardiovascular risk in nonhypertensive and nondiabetic individuals: The Taiwan I-Lan Longitudinal Aging Study. Sci Rep. 2018;8(1):5234. https://doi.org/10.1038/s41598-018-22997-0
  16. Li M., Hu X., Fan Y., et al. Hyperuricemia and the risk for coronary heart disease morbidity and mortality a systematic review and dose-response metaanalysis. Sci Rep. 2016;6:19520. https://doi.org/10.1038/srep19520
  17. Ye Z., Lu H., Long M., Li L. Baseline Serum Uric Acid Levels Are Associated with All-Cause Mortality in Acute Coronary Syndrome Patients after Percutaneous Coronary Intervention. Dis Markers. 2018;2018:9731374. https://doi.org/10.1155/2018/9731374
  18. Ekundayo O.J., Dell’Italia L.J., Sanders P.W., et al. Association between hyperuricemia and incident heart failure among older adults: a propensity-matched study. Int J Cardiol. 2010;142(3):279-287. https://doi.org/10.1016/j.ijcard.2009.01.010
  19. Huang H., Huang B., Li Y., et al. Uric acid and risk of heart failure: a systematic review and metaanalysis. Eur J Heart Fail. 2014;16(1):15-24. https://doi.org/10.1093/eurjhf/hft132
  20. Wannamethee S.G., Papacosta O., Lennon L., Whincup P.H. Serum uric acid as a potential marker for heart failure risk in men on antihypertensive treatment: The British Regional Heart Study. Int J Cardiol. 2018;252:187-192. https://doi.org/10.1016/j.ijcard.2017.11.083
  21. Tamariz L., Agarwal S, Soliman EZ, et al. Association of serum uric acid with incident atrial fibrillation (from the Atherosclerosis Risk in Communities —ARIC study). Am J Cardiol. 2011;108(9):1272-1276. https://doi.org/10.1016/j.amjcard.2011.06.043
  22. Kawasoe S, Kubozono T., Yoshifuku S., et al. Uric Acid Level and Prevalence of Atrial Fibrillation in a Japanese General Population of 285,882. Circ J. 2016;80(12):2453-2459. https://doi.org/10.1253/circj.CJ-16-0766
  23. Huang H., Huang B., Li Y., et al. Uric acid and risk of heart failure: a systematic review and meta-analysis. Eur J Heart Fail. 2014;16(1):15-24. https://doi.org/10.1093/eurjhf/hft132
  24. Mangge H., Zelzer S., Puerstner P., et al. Uric acid best predicts metabolically unhealthy obesity with increased cardiovascular risk in youth and adults. Obesity (Silver Spring). 2013;21(1):E71-E77. https://doi.org/10.1002/oby.20061
  25. Battelli M.G., Polito L., Bolognesi A. Xanthine oxidoreductase in atherosclerosis pathogenesis: not only oxidative stress. Atherosclerosis. 2014;237(2):562-567. https://doi.org/10.1016/j.atherosclerosis.2014.10.006
  26. Galassi F.M., Borghi C. A brief history of uric acid: From gout to cardiovascular risk factor. Eur J Intern Med. 2015;26(5):373. https://doi.org/10.1016/j.ejim.2015.04.005
  27. Topolyanskaya S.V., Vakulenko O.N., Semashkova A.E., Kupina L.M., Strizhova N.V. Giperurikemiya i serdechno-sosudistye zabolevaniya v starcheskom vozraste. Klinicheskaya meditsina. 2017;95(5):457-464. (In Russ.).
  28. Major T.J., Topless R.K., Dalbeth N., Merriman T.R. Evaluation of the diet wide contribution to serum urate levels: meta-analysis of population based cohorts. BMJ. 2018;363:k3951. https://doi.org/10.1136/bmj.k3951
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.