The current national immunization calendar is intended for the pediatric population; the general concept of adult immunization is absent, which does not protect target groups under the conditions of the changing epidemic situation and the state of population immunity. Objective — to substantiate and design a national vaccine schedule for adults. Material and methods. The investigation was conducted using the data available in the Russian and foreign literature, the assessments of the epidemic situation among the adult population in the Russian Federation, and the authors’ own studies. Results. The draft national adult immunization calendar consisting of two sections was designed and substantiated. The first section includes information on immunization of different age groups; the second contains that on immunization of groups at epidemiological and social risks. Conclusions. The introduction of the national adult immunization calendar and improvements in the institutional framework of vaccination will achieve further reductions in morbidity and mortality rates in the country.