Роль мелатонина в обеспечении мужского репродуктивного здоровья

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В статье представлен анализ актуальных данных литературы о проблемах мужской репродукции. Рассмотрены особенности регуляции процесса сперматогенеза в норме и при воздействии различных повреждающих факторов. Описана роль мелатонина в качестве важнейшего регулятора сперматогенеза. Отражены основные биохимические антиоксидантные свойства мелатонина. Продемонстрированы результаты исследований, посвященных изучению действия мелатонина на мужскую фертильность. Основываясь на данных литературы, можно предположить, что влияние мелатонина на гипоталамо-гипофизарно-гонадную ось и на уровень тестостерона является одним из ключевых факторов регуляции сперматогенеза. Уникальные метаболические эффекты мелатонина позволяют заключить, что его применение в андрологии может оказаться перспективной фармакотерапевтической стратегией в борьбе с мужским бесплодием.

Ключевые слова:

сперматогенез

регуляция

мелатонин

Авторы:

Ершов А.В.

ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава Российской Федерации (Сеченовский университет);
ФГБНУ «Федеральный научно-клинический центр реаниматологии и реабилитологии» Минобрнауки России

ORCID: 0000-0001-5758-8552

Манасова З.Ш.

ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава Российской Федерации (Сеченовский университет)

ORCID: 0000-0002-3003-4362

Андриуца Н.С.

ORCID: 0000-0001-5425-7707

Дата поступления:

03.08.2023

Дата принятия в печать:

29.08.2023

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