Features of the expression of sex steroid hormone receptors in first detected and recurrent external genital endometriosis

Aliyeva Farakh T.; Paramonova N.B.; Bryunin D.V.; Bakhvalova A.A.; Aliyeva Fidan T.

doi:https://doi.org/10.17116/repro20222802140

Aliyeva Farakh T.

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation

Paramonova N.B.

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation

Bryunin D.V.

Sechenov First Moscow State University (Sechenov University)

Bakhvalova A.A.

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation

Aliyeva Fidan T.

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation

Features of the expression of sex steroid hormone receptors in first detected and recurrent external genital endometriosis

Authors:

Aliyeva Farakh T., Paramonova N.B., Bryunin D.V., Bakhvalova A.A., Aliyeva Fidan T.

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Journal: Russian Journal of Human Reproduction. 2022;28(2): 40‑46

DOI: 10.17116/repro20222802140

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To cite this article:

Aliyeva Farakh T, Paramonova NB, Bryunin DV, Bakhvalova AA, Aliyeva Fidan T. Features of the expression of sex steroid hormone receptors in first detected and recurrent external genital endometriosis. Russian Journal of Human Reproduction. 2022;28(2):40‑46. (In Russ.)
https://doi.org/10.17116/repro20222802140

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)

Использование инфографики авторами научных работ

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GOAL OF INVESTIGATION

To study the features of the expression of estrogen (ER-α) and progesterone (PR-A) receptors in the epithelium and stroma of the endometrioid infiltrate (EI) and capsules of the endometrioid ovarian cyst in first detected and recurrent external genital endometriosis (EGE).

MATERIAL AND METHODS

88 patients with EGE were examined, out of them, 48 women had a recurrence of EGE (main group). The study included 40 women with first detected EGE (comparison group). All patients with EGE in the proliferative phase of the menstrual cycle underwent surgical intervention using a laparoscopic access: excision/destruction of endometrioid infiltrates/heterotopias, resection of the ovary (removal of the capsule of the endometrioid cyst). Biological material obtained during surgical operation were subjected to histological and immunohistochemical study to determine the expression levels of steroid receptors of the hormones.

RESULTS

In patients with recurrent EGE in the epithelium of the endometriomas there are revealed a statistically significant increase in the expression of ER-α and PR-A, compared with patients with newly diagnosed EGE. At the same time, there is a slight decrease in the expression of ER-α and PR-A in the endometriomas stroma compared to patients with newly diagnosed EGE (p>0.05). Increased expression of ER by epithelial cells, as well as an imbalance between the expression of ER-α and PR-A in epithelial and stromal cells of endometrioid ovarian cysts may be among the most important causes of progression and recurrence of endometriosis.

Keywords:

recurrent endometriosis

estrogen receptors

progesterone receptors

Authors:

Aliyeva Farakh T.

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation

Paramonova N.B.

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation

Bryunin D.V.

Sechenov First Moscow State University (Sechenov University)

Bakhvalova A.A.

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation

Aliyeva Fidan T.

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation

Received:

05.04.2022

Accepted:

07.04.2022

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References:

Borisova AV, Kozachenko AV, Frankevich VE, Chagovec VV, Kononihin AS, Starodubceva NL, Kogan EA, Adamyan LV. Risk factors for recurrence of external genital endometriosis after surgical treatment: a prospective cohort study. Medicinskij sovet. 2018;7:32-38. (In Russ.). https://doi.org/10.21518/2079-701X-2018-7-32-38
Chernuha GE, Il’ina LM, Adamyan LV, Pavlovich SV. Deep infiltrative endometriosis: postoperative relapses and possible ways of their prevention. Akusherstvo i ginekologiya. 2015;8:39-46. (In Russ.).
Shestakova IG, Ipastova ID. Endometrioz: novyj konsensus — novye resheniya. Global’nyj konsensus po vedeniyu bol’nyh endometriozom kak pervyj shag k sozdaniyu otraslevyh standartov. Informacionnyj byulleten’. M.: Redakciya zhurnala StatusPraesens; 2014. (In Russ.).
Lessey BA, Palomino WA, Apparao KB, Young SL, Lininger RA. Estrogen receptor-alpha (ER-alpha) and defects in uterine receptivity in women. Reproductive Biology and Endocrinology: RB&E. 2006;4(suppl 1):9. https://doi.org/10.1186/1477-7827-4-S1-S9
Marquardt RM, Kim TH, Shin JH, Jeong JW. Progesterone and Estrogen Signal in gin the Endometrium: What Goes Wrong in Endometriosis? International Journal of Molecular Sciences. 2019;20(15): 3822. https://doi.org/10.3390/ijms20153822
Mihaleva LM, Solomatina AA, Hovanskaya TN, Chabieva LB, Gracheva NA, Chigraj LV, Mihalev SA. Morphofunctional state and receptivity of the endometrium in patients with ovarian endometriosis. Problemy reprodukcii. 2020;26(3):68-75. (In Russ.). https://doi.org/10.17116/repro20202603168
Paramonova NB, Kogan EA, Kolotovkina AV, Burmenskaia OV. The morphological and molecular biological signs of impaired endometrial receptivity in infertility in women suffering from external genital endometriosis. Arkhiv patologii. 2018;80(3):11-18. (In Russ.). https://doi.org/10.17116/patol201880311-18
Yarmolinskaya MI, Rusina EI, Hachaturyan AR, Florova MS. Clinic and diagnosis of genital endometriosis. Zhurnal akusherstva i zhenskih boleznej. 2016;65(5):4-21. (In Russ.). https://doi.org/10.17816/JOWD6554-21
Denisova VM, Yarmolinskaya MI, Polyakova VO, Rulev VV, Durnova AO. Features of the expression of sex steroid hormone receptors in external genital endometriosis. Molekulyarnaya medicina. 2014;5: 29-32. (In Russ.).
Christofolini DM, Vilarino FL, Mafra FA, André GM, Bianco B, Barbosa CP. Combination of polymorphisms in luteinizing hormone β, estrogen receptor β and progesterone receptor and susceptibility to infertility and endometriosis. European Journal of Obstetrics, Gynecology, and Reproductive Biology. 2011;158(2):260-264. https://doi.org/10.1016/j.ejogrb.2011.06.028
Silva RC, Costa IR, Bordin BM, Silva CT, Souza SR, Júnior CL, Frare AB, Moura KK. RsaI polymorphism of the ERβ gene in women with endometriosis. Genetics and Molecular Research: GMR. 2011;10(1):465-470. https://doi.org/10.4238/vol10-1gmr940
Kogan EA, Akopova EO, Unanyan AL. Infertility in endometriosis: a brief outline of modern ideas. Prostranstvo i vremya. 2017;27(1): 251-259. (In Russ.).
Pshenichnyuk EYu, Asaturova AV, Adamyan LV, Zajcev NV. Immunohistochemical features of eutopic and ectopic endometrium in patients with recurrent ovarian endometrioid cysts. Akusherstvo i ginekologiya. 2018;3:84-95. (In Russ.). https://doi.org/10.18565/aig.2018.3.84-95