The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Rybalov M.A.

Pavlov First St. Petersburg State Medical University

Borovets S.Yu.

Pavlov First St. Petersburg State Medical University

Al-Shukri S.Kh.

Pavlov First St. Petersburg State Medical University

Borovskaya T.G.

Tomsk National Research Medical Center of the Russian Academy of Sciences

Vychuzhanina A.V.

Tomsk National Research Medical Center of the Russian Academy of Sciences

Kamalova S.I.

Tomsk National Research Medical Center of the Russian Academy of Sciences

Apryatina V.A.

Saint Petersburg Institute of Bioregulation and Gerontology

The efficacy of arginyl-glycinate zinc complex in the treatment of male infertility in experimental and clinical studies

Authors:

Rybalov M.A., Borovets S.Yu., Al-Shukri S.Kh., Borovskaya T.G., Vychuzhanina A.V., Kamalova S.I., Apryatina V.A.

More about the authors

Journal: Russian Journal of Human Reproduction. 2022;28(1): 136‑141

DOI: 10.17116/repro202228011136

Read: 26235 times

Download PDF (RU)
Contact the author
Table of contents

THE EFFICACY OF ARGINYL-GLYCINATE ZINC COMPLEX IN THE TREATMENT OF MALE INFERTILITY IN EXPERIMENTAL AND CLINICAL STUDIES
THE EFFICACY OF ARGINYL-GLYCINATE ZINC COMPLEX IN THE TREATMENT OF MALE INFERTILITY IN EXPERIMENTAL AND CLINICAL STUDIES

To cite this article:

Rybalov MA, Borovets SYu, Al-Shukri SKh, Borovskaya TG, Vychuzhanina AV, Kamalova SI, Apryatina VA. The efficacy of arginyl-glycinate zinc complex in the treatment of male infertility in experimental and clinical studies. Russian Journal of Human Reproduction. 2022;28(1):136‑141. (In Russ.)
https://doi.org/10.17116/repro202228011136

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Refe­rence value of the proportion of spermatozoa with fragmented DNA in the ejaculate of men from the North-Western region of Russia. Russian Journal of Human Reproduction. 2025;(1):94-104
Abstract:

OBJECTIVE

To evaluate the effectiveness of rectal administration of zinc arginyl glycinate dihydrochloride (ZAG) at a dose of 16 mg/kg in an experimental model of male infertility (pathozoospermia) and compare the results obtained with the currently available data from clinical trials.

MATERIAL AND METHODS

The study used 30 outbred male Wistar rats, sexually mature (11 weeks), divided into 3 groups. The experimental group was injected with ZAG at a dose of 16 mg/kg, the background group consisted of intact animals, the control group received suppositories that did not contain an active substance (placebo). The test substances were administered rectally in the form of gelatin suppositories once a day, every day for 5 days before and 5 days after the administration of the etoposide (30 mg/kg) that simulates the pathology. A day after the last injection, indicators characterizing the morphofunctional state of male germ cells were determined.

RESULTS

The pharmacological activity of the ZAG preparation was revealed in the experiment with oligo-, astheno- and teratozoospermia, which was characterized by a high degree of effect, the differences were statistically significant compared with the background and control groups.

CONCLUSIONS

The obtained experimental data on ZAG activity correspond to the results of clinical studies of the drug Prostatilen AC, one of the active substances of which is the investigated complex, which has proven its effectiveness in real clinical practice in the treatment of patients with chronic prostatitis and impaired fertility, what makes it possible to recommend the use of this substance in andrological practice as part of combined drugs for the treatment of various types of pathospermia.

Keywords:

zinc arginyl glycinate
male infertility
pathozoospermia model
impaired fertility
experimental study

Authors:

Rybalov M.A.

Pavlov First St. Petersburg State Medical University

Borovets S.Yu.

Pavlov First St. Petersburg State Medical University

Al-Shukri S.Kh.

Pavlov First St. Petersburg State Medical University

Borovskaya T.G.

Tomsk National Research Medical Center of the Russian Academy of Sciences

Vychuzhanina A.V.

Tomsk National Research Medical Center of the Russian Academy of Sciences

Kamalova S.I.

Tomsk National Research Medical Center of the Russian Academy of Sciences

Apryatina V.A.

Saint Petersburg Institute of Bioregulation and Gerontology

Received:

24.12.2021

Accepted:

29.12.2021

Close metadata

References:

  1. Vallee BL, Falchuk KH. The biochemical basis of zinc physiology. Physiological Reviews. 1993;73(1):79-118.  https://doi.org/10.1152/physrev.1993.73.1.79
  2. Kerns K, Zigo M, Sutovsky P. Zinc: a necessary ion for mammalian sperm fertilization competency. International Journal of Molecular Sciences. 2018;19(12):4097. https://doi.org/10.3390/ijms19124097
  3. Wu J, Wu S, Xie Y, Wang Z, Wu R, Cai J, Luo X, Huang S, You L. Zinc protects sperm from being damaged by reactive oxygen species in assisted reproduction techniques. Reproductive Biomedicine Online. 2015;30(4):334-339.  https://doi.org/10.1016/j.rbmo.2014.12.008
  4. Guidobaldi HA, Cubilla M, Moreno A, Molino MV, Bahamondes L, Giojalas LC. Sperm chemorepulsion, a supplementary mechanism to regulate fertilization. Human Reproduction. 2017;32(8):1560-1573. https://doi.org/10.1093/humrep/dex232
  5. Omu AE, Al-Azemi MK, Kehinde EO, Anim JT, Oriowo MA, Mathew TC. Indications of the mechanisms involved in improved sperm parameters by zinc therapy. Medical Principles and Practice. 2008;17(2):108-116.  https://doi.org/10.1159/000112963
  6. Giacone F, Condorelli RA, Mongioì LM, Bullara V, La Vignera S, Calogero AE. In vitro effects of zinc, D-aspartic acid, and coenzyme-Q10 on sperm function. Endocrine. 2017;56(2):408-415.  https://doi.org/10.1007/s12020-016-1013-7
  7. Wu G, Bazer FW, Davis TA, Kim SW, Li P, Rhoads JM, Satterfield MC, Smith SB, Spencer TE, Yin Y. Arginine metabolism and nutrition in growth, health and disease. Amino Acids. 2009;37(1):153-168.  https://doi.org/10.1007/s00726-008-0210-y
  8. Öztürk C, Güngör Ş, Ataman MB, Bucak MN, Başpinar N, Ili P, Inanç ME. Effects of arginine and trehalose on post-thawed bovine sperm quality. Acta Veterinaria Hungarica. 2017;65(3):429-439.  https://doi.org/10.1556/004.2017.040
  9. Kobori Y, Suzuki K, Iwahata T, Shin T, Sadaoka Y, Sato R, Nishio K, Yagi H, Arai G, Soh S, Okada H, Strong JM, Rohdewald P. Improvement of seminal quality and sexual function of men with oligoasthenoteratozoospermia syndrome following supplementation with L-arginine and Pycnogenol. Archivio Italiano di Urologia, Andrologia. 2015;87(3):190-193.  https://doi.org/10.4081/aiua.2015.3.190
  10. Hatakeyama S, Sugihara K, Lee SH, Nadano D, Nakayama J, Ohyama C, Fukuda MN. Enhancement of Human Sperm Motility by Trophinin Binding Peptide. The Journal of Urology. 2008;180(2):767-771.  https://doi.org/10.1016/j.juro.2008.03.185
  11. Wang Z, Zhang J, Wang L, Li W, Chen L, Li J, Zhao D, Zhang H, Guo X. Glycine mitigates renal oxidative stress by suppressing Nox4 expression in rats with streptozotocin-induced diabetes. Journal of Pharmacological Sciences. 2018;137(4):387-394.  https://doi.org/10.1016/j.jphs.2018.08.005
  12. Amin FU, Shah SA, Kim MO. Glycine inhibits ethanol-induced oxidative stress, neuroinflammation and apoptotic neurodegeneration in postnatal rat brain. Neurochemistry International. 2016;96:1-12.  https://doi.org/10.1016/j.neuint.2016.04.001
  13. Savateeva-Lyubimova TN, Sivak KV, Malinin VV. The effect of prostatilen AC suppositories on the course of experimental prostatitis. Urologiya. 2012;4:60-62. (In Russ.).
  14. Al-Shukri SKh, Petlenko SV, Borovets SYu, Rybalov MA, Soroka IV, Stukan NI. The effect of Prostatilen AC and Prostatilen drugs on the level of antisperm antibodies in the ejaculate in the treatment of patients with chronic abacterial prostatitis and concomitant reproductive disorders. Andrologiya i genital’naya khirurgiya. 2016;17(1): 40-43. (In Russ.). https://doi.org/10.17650/2070-9781-2016-17-1-40-43
  15. Borovets SYu, Rybalov MA, Gorbachev AG, Al-Shukri SKh. The effect of Prostatilen AC on sperm DNA fragmentation in the treatment of patients with chronic abacterial prostatitis and concomitant reproductive function disorders. Andrologiya i genital’naya khirurgiya. 2017;18(3):54-58. (In Russ.). https://doi.org/10.17650/2070-9781-2017-18-3-54-58
  16. Zhukov OB, Evdokimov VV, Bragina EE. Improving the quality of life and morphofunctional characteristics of spermatozoa in men with chronic abacterial prostatitis and programs of pre-pregnancy preparation for fatherhood. Andrologiya i genital’naya khirurgiya. 2017;18(1):3-9. (In Russ.). https://doi.org/10.17650/2070-9781-2017-18-1-102-108
  17. Zhukov OB, Bragina EE, Levina AV, Evdokimov VV, Terushkin RA, Akramov MM, Shakhov AS, Vasilyev AE. Comparison of the effectiveness of drugs containing a combination of arginine and zinc in the treatment of male infertility. Andrologiya i genital’naya khirurgiya. 2020;21(2):26-35. (In Russ.). https://doi.org/10.17650/2070-9781-2020-21-2-26-35
  18. Kuzmin IV, Borovets SYu, Gorbachev AG, Al-Shukri SKh. Prostatic bioregulatory polypeptide prostatilen: pharmacological properties and experience of 30 years of clinical use in urology. Urologicheskie vedomosti. 2020;10(3):243-258. (In Russ.). https://doi.org/10.17816/uroved42472
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.