Females’ fertility preservation in malignancies

Vartanyan E.V.; Dobrokhotova Yu.E.; Devyatova E.A.; Tsaturova K.A.

doi:https://doi.org/10.17116/repro20202604168

Vartanyan E.V.

Department of Obstetrics and Gynecology of Pirogov Russian National Research Medical University;
Clinic for Assisted Reproductive Technologies «Test-tube babies»

Dobrokhotova Yu.E.

Pirogov Russian National Research Medical University

SPIN RSCI: 2925-9948
Scopus AuthorID: 57188592250
ORCID: 0000-0002-7830-2290

Devyatova E.A.

Clinic for Assisted Reproductive Technologies «Test-tube babies»

Tsaturova K.A.

Clinic for Assisted Reproductive Technologies «Test-tube babies»

Females’ fertility preservation in malignancies

Authors:

Vartanyan E.V., Dobrokhotova Yu.E., Devyatova E.A., Tsaturova K.A.

More about the authors

Journal: Russian Journal of Human Reproduction. 2020;26(4): 68‑76

DOI: 10.17116/repro20202604168

Read: 5705 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Vartanyan EV, Dobrokhotova YuE, Devyatova EA, Tsaturova KA. Females’ fertility preservation in malignancies. Russian Journal of Human Reproduction. 2020;26(4):68‑76. (In Russ.)
https://doi.org/10.17116/repro20202604168

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)

Использование инфографики авторами научных работ

Close metadata

Recommended articles:

The use of grape polyphenols in combination with magnetic therapy in patients with bronchial asthma who have suffered a new coronavirus infection. Problems of Balneology, Physiotherapy and Exercise Therapy. 2025;(4):14-19

Results of a multicenter international study on the efficacy and safety of Remaxol in patients with drug-induced liver injury during antitumor therapy. P.A. Herzen Journal of Oncology. 2025;(5):26-33

Abstract:

Malignancies in women are twice more often diagnosed, therefore in 10% women of reproductive age. Anticancer treatment is connected with strong gonadotoxicity and is the major reason of fertility loss in young women and adolescents suffering from malignancies. Fertility preservation in these of patients is one of intensively developing branches of medical science and practice. This review is based on recently published in MedLine and EMBASE data with being discussed nowadays problems and perspective trends in the field of oncofertility. Patients and health specialists face medical, economic, social and law barriers in the field of fertility preservation. We need studying of simplifying decision-making process deeply to develop adequate fertility preservation procedures. Examination of psychosocial and practical profiles which oppose realization of fertility preservation management can help to develop effective medical services in this field. The degree of influencing factors like poor oncological prognosis, ethical or religious dogmas also deserves further evaluation.

Keywords:

malignancies

risk

female fertility preservation

anticancer treatment

gonadotoxicity

Authors:

Vartanyan E.V.

Department of Obstetrics and Gynecology of Pirogov Russian National Research Medical University;
Clinic for Assisted Reproductive Technologies «Test-tube babies»

Dobrokhotova Yu.E.

Pirogov Russian National Research Medical University

SPIN RSCI: 2925-9948
Scopus AuthorID: 57188592250
ORCID: 0000-0002-7830-2290

Devyatova E.A.

Clinic for Assisted Reproductive Technologies «Test-tube babies»

Tsaturova K.A.

Clinic for Assisted Reproductive Technologies «Test-tube babies»

Received:

20.03.2020

Accepted:

01.05.2020

Close metadata

References:

Massarotti C, Scaruffi P, Lambertini M, Remorgida V, Del Mastro L, Anserini P. State of the art on oocyte cryopreservation in female cancer patients: a critical review of the literature. Cancer Treatment Reviews. 2017;57:50-57. https://doi.org/10.1016/j.ctrv.2017.04.009
Salama M, Woodruff TK. Anticancer Treatments and Female Fertility: Clinical Concerns and Role of Oncologists in Oncofertility Practice. Expert Review of Anticancer Therapy. 2017;17(8):687-692. https://doi.org/10.1080/14737140.2017.1335199
Jones G, Hughes J, Mahmoodi N, Smith E, Skull J, Ledger W. What factors hinder the decisionmaking process for women with cancer and contemplating fertility preservation treatment? Human Reproduction Update. 2017;23(4):433-457. https://doi.org/10.1093/humupd/dmx009
Silber Sh, Kagawa N, Kuwayama M, Gosden R. Duration of fertility after fresh and frozen ovary transplantation. Fertility and Sterility. 2010;94(6):2191-2196. https://doi.org/10.1016/j.fertnstert.2009.12.073
Chung K, Donnez J, Ginsburg E, Meirow D. Emergency IVF versus ovarian tissue cryopreservation: decision making in fertility preservation for female cancer patients. Fertility and Sterility. 2013;99(6): 1534-1542. https://doi.org/10.1016/j.fertnstert.2012.11.057
Martinez F. Update on fertility preservation from the Barcelona International Society for Fertility Preservation—ESHRE—ASRM 2015 expert meeting: indications, results and future perspectives. Fertility and Sterility. 2017;108(3):407-415. https://doi.org/10.1016/j.fertnstert.2017.05.024
Sonigo C, Simon C, Boubaya M, Benoit A, Sifer C, Sermondade N, Grynberg M. What threshold values of antral follicle count and serum AMH levels should be considered for oocyte cryopreservation after in vitro maturation? Human Reproduction. 2016;31(7):1493-1500. https://doi.org/10.1093/humrep/dew102
Donnez J, Dolmans MM, Pellicer A, Diaz-Garcia C, Sanchez Serrano M, Schmidt KT, Ernst E, Luyckx V, Andersen CY. Restoration of ovarian activity and pregnancy after transplantation of cryopreserved ovarian tissue: a review of 60 cases of reimplantation. Fertility and Sterility. 2013;99(6):1503-1513. https://doi.org/10.1016/j.fertnstert.2013.03.030
Fisch B, Abir R. Female fertility preservation: past, present and future. Reproduction. 2018;156(1):11-27. https://doi.org/10.1530/REP -17-0483
Johnson LN, Dillon KE, Sammel MD, Efymow BL, Mainigi MA, Dokras A, Gracia CR. Response to ovarian stimulation in patients facing gonadotoxic therapy. Reproductive BioMedicine Online. 2013; 26(4):337-344. https://doi.org/10.1016/j.rbmo.2013.01.003
Martinez M, Rabadan S, Domingo J, Cobo A, Pellicer A, Garcia-Velasco JA. Obstetric outcome after oocyte vitrification and warming for fertility preservation in women with cancer. Reproductive BioMedicine Online. 2014;29(6):722-728. https://doi.org/10.1016/j.rbmo.2014.09.002
Druckenmiller S, Goldman KN, Labella PA, Fino ME, Bazzocchi A, Noyes N. Successful Oocyte Cryopreservation in Reproductive-Aged Cancer Survivors. Obstetrics and Gynaecology. 2016; 127(3):474480. https://doi.org/10.1097/AOG.0000000000001248
Cobo A, García-Velasco JA, Coello A, Domingo J, Pellicer A, Remohí J. Oocyte Vitrification as an Efficient Option for Elective Fertility Preservation. Fertility and Sterility. 2016;105(3):755-764.e8. https://doi.org/10.1016/j.fertnstert.2015.11.027
Alvares RM, Ramanathan P. Fertility Preservation in Female Oncology Patients: The Influence of the Type of Cancer on Ovarian Stimulation Response. Human Reproduction. 2018;33(11):2051-2059. https://doi.org/10.1093/humrep/dew158
Specchia C, Baggiani A, Immediata V, Ronchetti C, Cesana A, Smeraldi A, Scaravelli G, Levi-Setti PE. Oocyte Cryopreservation in Oncological Patients: Eighteen YearsExperience of a Tertiary Care Referral Center. Frontiers in Endocrinology. 2019;10:600. https://doi.org/10.3389/fendo.2019.00600
Abir R, Ben-Aharon I, Garor R, Yaniv I, Ash S, Stemmer SM, Ben-Haroush A, Freud E, Kravarusic D, Sapir O, Fisch B. Cryopreservation of in vitro matured oocytes in addition to ovarian tissue freezing for fertility preservation in paediatric female cancer patients before and after cancer therapy. Human Reproduction. 2016;31(4): 750-762. https://doi.org/10.1093/humrep/dew007
Lee YJ, Kim DY, Suh DS, Kim JH, Kim YM, Kim YT, Nam JH. Feasibility of uterine preservation in the management of early-stage uterine adenosarcomas: a single institute experience. World Journal of Surgical Oncology. 2017;15(1):87. https://doi.org/10.1186/s12957-017-1137-0