According to many authors the premature rise in plasma progesterone concentration on the peak of follicles stimulation stage is a frequent phenomenon negatively affecting an IVF protocol outcome. Numerous scientific researches showed that the likelihood of high progesterone registration at the end of the IVF cycle first phase is directly correlated with the intensity of the conducted induction, primarily FSH. LH role in the descent of the follicular hyperprogesteronemia is not monosemantic. There are few world observations of blood progesterone level comparing the induction protocols with GnRH antagonists and use of different LH/FSH ratios (rLH in particular). 367 patients took part in this research: 246 (67%) of them had a superovulation stimulation in the protocol with GnRH antagonists while the rest 121 patients were observed in the modified natural cryocycle. This research established the threshold progesterone value, that is 1.2 ng/ml defining the success of the carried IVF. The reliable difference in blood progesterone level when using the mix rLH+ rFSH in the ratio 1/2 was revealed in comparison to the other groups where only rFSH or HMG, with the comparable deviations of progesterone level, were used for induction. It was shown that the reasonable addition of rLH in protocols with gonadotropic stimulation clarifies the accessing progesterone in blood plasma. It was shown that the diameter of the maximum follicular considerably influences the blood progesterone level, and the quantity of preovulatory folliculars influences progesterone level including positive effect but at less extent. It was demonstarated that high progesterone level (≥1.2 ng/ml) is combined with the bigger quantity of mature oocytes during the punction, but authentically does not change the quantity of the received embryos. It was shown that the frequency of pregnancies in the modified natural cryocycles was 1.3 times higher than when IVF ovulation stimulation was carried out.