THE EFFECTS OF PYRROLIDINE DITHIOCARBAMATE AND LINOLEIC ACID ON OOCYTE MEIOTIC MATURATION AND THE SURVIVAL OF CUMULUS CELLS IN MICE

Blashkiv T.V.; Shepel' E.A.; Voznesenskaia T.Iu.

doi:https://doi.org/

Blashkiv T.V.

Institut fiziologii im. A.A. Bogomol'tsa NAN Ukrainy, Kiev

Shepel' E.A.

Institut fiziologii im. A.A. Bogomol'tsa NAN Ukrainy, Kiev

Voznesenskaia T.Iu.

Institut fiziologii im. A.A. Bogomol'tsa NAN Ukrainy, Kiev

THE EFFECTS OF PYRROLIDINE DITHIOCARBAMATE AND LINOLEIC ACID ON OOCYTE MEIOTIC MATURATION AND THE SURVIVAL OF CUMULUS CELLS IN MICE

Authors:

Blashkiv T.V., Shepel' E.A., Voznesenskaia T.Iu.

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Journal: Russian Journal of Human Reproduction. 2012;(1): 17‑20

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To cite this article:

Blashkiv TV, Shepel' EA, Voznesenskaia TIu. THE EFFECTS OF PYRROLIDINE DITHIOCARBAMATE AND LINOLEIC ACID ON OOCYTE MEIOTIC MATURATION AND THE SURVIVAL OF CUMULUS CELLS IN MICE. Russian Journal of Human Reproduction. 2012;(1):17‑20. (In Russ.)

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)

Использование инфографики авторами научных работ

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Abstract:

The influence of specific NF-kB inhibitor pyrrolidine dithiocarbamate (PDTC) on murine oocyte meiotic maturation and the survival of cumulus cells have been investigated. The effect of LA-induced activation of NF-kB, as well as the number of heterochromatin granules after oxidative stress were analyzed. PDTC has been shown to inhibit the oocyte meiotic maturation, decrease the number of viable cumulus cells and significantly increase the number of apoptotic cells, LA caused the dysfunction of cumulus cells.

Keywords:

NF-kВ

oocytes

cumulus cells

apoptosis

necrosis

Authors:

Blashkiv T.V.

Institut fiziologii im. A.A. Bogomol'tsa NAN Ukrainy, Kiev

Shepel' E.A.

Institut fiziologii im. A.A. Bogomol'tsa NAN Ukrainy, Kiev

Voznesenskaia T.Iu.

Institut fiziologii im. A.A. Bogomol'tsa NAN Ukrainy, Kiev

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References:

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