The state of the guanylate cyclase mechanism of vasodilatation before and after thyroidectomy in the patients presenting with toxic goiter

Il'icheva E.A.

FGBU "Nauchnyĭ tsentr rekonstruktivnoĭ i vosstanovitel'noĭ khirurgii" SO RAN, Irkutsk

Tarnueva I.F.

FGBU "Nauchnyĭ tsentr rekonstruktivnoĭ i vosstanovitel'noĭ khirurgii" SO RAN, Irkutsk

Pivovarov Iu.I.

FGBU "Nauchnyĭ tsentr rekonstruktivnoĭ i vosstanovitel'noĭ khirurgii" SO RAN, Irkutsk

Koriakina L.B.

FGBU "Nauchnyĭ tsentr rekonstruktivnoĭ i vosstanovitel'noĭ khirurgii" SO RAN, Irkutsk

Chizhova E.A.

FGBU "Nauchnyĭ tsentr rekonstruktivnoĭ i vosstanovitel'noĭ khirurgii" SO RAN, Irkutsk

The state of the guanylate cyclase mechanism of vasodilatation before and after thyroidectomy in the patients presenting with toxic goiter

Authors:

Il'icheva E.A., Tarnueva I.F., Pivovarov Iu.I., Koriakina L.B., Chizhova E.A.

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Journal: Problems of Endocrinology. 2014;60(3): 15‑22

DOI: 10.14341/probl201460315-22

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To cite this article:

Il'icheva EA, Tarnueva IF, Pivovarov IuI, Koriakina LB, Chizhova EA. The state of the guanylate cyclase mechanism of vasodilatation before and after thyroidectomy in the patients presenting with toxic goiter. Problems of Endocrinology. 2014;60(3):15‑22. (In Russ.)
https://doi.org/10.14341/probl201460315-22

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The state of the guanylate cyclase activity of myocytes was evaluated from the increment in the diameter of the brachial artery in response to the exogenous administration of nitroglycerin (#D^NO) in 64 samples obtained from 44 patients. A total of 23 studies were carried out during thyrotoxicosis decompensation, 28 ones in the phase of medicamental thyrotoxicosis, and 13 within 5-6 days after thyroidectomy. The guanylate cyclase activity of myocytes was found to correlate with the production of vascular endothelium factors. Thyroidectomy in the patients with toxic goiter and reduced guanylate cyclase activity of myocytes was associated with the statistically significant increase of endothelium-independent vasodilatation.

Keywords:

endothelium-independent vasodilatation

endothelin

nitric oxide

toxic goiter

thyroidectomy

Authors:

Il'icheva E.A.

FGBU "Nauchnyĭ tsentr rekonstruktivnoĭ i vosstanovitel'noĭ khirurgii" SO RAN, Irkutsk

Tarnueva I.F.

FGBU "Nauchnyĭ tsentr rekonstruktivnoĭ i vosstanovitel'noĭ khirurgii" SO RAN, Irkutsk

Pivovarov Iu.I.

FGBU "Nauchnyĭ tsentr rekonstruktivnoĭ i vosstanovitel'noĭ khirurgii" SO RAN, Irkutsk

Koriakina L.B.

FGBU "Nauchnyĭ tsentr rekonstruktivnoĭ i vosstanovitel'noĭ khirurgii" SO RAN, Irkutsk

Chizhova E.A.

FGBU "Nauchnyĭ tsentr rekonstruktivnoĭ i vosstanovitel'noĭ khirurgii" SO RAN, Irkutsk

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