Association of the CCR5 gene with type 1 diabetes mellitus

Kopylova O.I.; Kuraeva T.L.; Lavrikova E.Iu.; Titovich E.V.; Nikitin A.G.; Smirnova G.E.; Peterkova V.A.; Dedov I.I.; Nosikov V.V.

doi:https://doi.org/

Kopylova O.I.

Institut biokhimicheskoĭ fiziki im. N.M. Émanuélia RAN

Kuraeva T.L.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr Minzdravsotsrazvitiia Rossiĭskoĭ Federatsii, Moskva

Lavrikova E.Iu.

Institut biokhimicheskoĭ fiziki im. N.M. Émanuélia RAN

Titovich E.V.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr Minzdravsotsrazvitiia Rossiĭskoĭ Federatsii, Moskva

Nikitin A.G.

Institut biokhimicheskoĭ fiziki im. N.M. Émanuélia RAN

Smirnova G.E.

FGBU "Éndokrinologicheskiĭ nauchnyĭ tsentr" MZ RF, Moskva

Peterkova V.A.

Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Dedov I.I.

Endocrinology Research Centre

Nosikov V.V.

Institut biokhimicheskoĭ fiziki im. N.M. Émanuélia RAN

Association of the CCR5 gene with type 1 diabetes mellitus

Authors:

Kopylova O.I., Kuraeva T.L., Lavrikova E.Iu., Titovich E.V., Nikitin A.G., Smirnova G.E., Peterkova V.A., Dedov I.I., Nosikov V.V.

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Journal: Problems of Endocrinology. 2013;59(2): 3‑6

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To cite this article:

Kopylova OI, Kuraeva TL, Lavrikova EIu, et al. . Association of the CCR5 gene with type 1 diabetes mellitus. Problems of Endocrinology. 2013;59(2):3‑6. (In Russ.)

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Abstract:

Aim of the study. To elucidate the association between the polymorphous marker A/del132 of the CCR5 gene with type 1 diabetes mellitus. Materials and methods. The study included 177 patients with type 1 diabetes mellitus (DM1) and 408 healthy subjects (ethnic Russians). CR5 alleles and genotypes were identified with the use of the real-time amplification technique. Results. It was shown that the CCR5 allele without 32 base pair deletion (allele A) predominated in both diabetic patients and diabetes-free subjects. The difference between their occurrence in the two groups was insignificant. At the same time, we documented a significant rise in the frequency of del132/del132 genotype in the diabetic patients compared with the healthy subjects (p=0.008). It is concluded that carriers of the CCR5-del32/del32 genotype in the Russian population of Moscow are at high risk of developing type 1 diabetes mellitus.

Keywords:

type 1 diabetes mellitus

CCR5 gene

32 base pair deletion.

Authors:

Kopylova O.I.

Institut biokhimicheskoĭ fiziki im. N.M. Émanuélia RAN

Kuraeva T.L.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr Minzdravsotsrazvitiia Rossiĭskoĭ Federatsii, Moskva

Lavrikova E.Iu.

Institut biokhimicheskoĭ fiziki im. N.M. Émanuélia RAN

Titovich E.V.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr Minzdravsotsrazvitiia Rossiĭskoĭ Federatsii, Moskva

Nikitin A.G.

Institut biokhimicheskoĭ fiziki im. N.M. Émanuélia RAN

Smirnova G.E.

FGBU "Éndokrinologicheskiĭ nauchnyĭ tsentr" MZ RF, Moskva

Peterkova V.A.

Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Dedov I.I.

Endocrinology Research Centre

Nosikov V.V.

Institut biokhimicheskoĭ fiziki im. N.M. Émanuélia RAN

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