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Yutskovskaya Ya.A.

LLC «Clinic of Professor Yutskovskaya»

Saybel A.V.

Clinic of Professor Yutskovskaya

Chakhoyan L.R.

Levon Chakhoyan’s Rejuvenation Clinic

Supilnikov A.A.

Medical University Reaviz

Ovcharenko T.A.

Pavlov First St. Petersburg State Medical University of the Ministry of Health of Russia

Terentyev A.Yu.

Medical and Humanitarian Institute

Mishurinskaya E.A.

Pirogov Russian National Research Medical University

Variable anatomy of facial muscles in the light of botulinum toxin injections

Authors:

Yutskovskaya Ya.A., Saybel A.V., Chakhoyan L.R., Supilnikov A.A., Ovcharenko T.A., Terentyev A.Yu., Mishurinskaya E.A.

More about the authors

Journal: Plastic Surgery and Aesthetic Medicine. 2022;(4): 102‑119

Read: 56670 times


To cite this article:

Yutskovskaya YaA, Saybel AV, Chakhoyan LR, Supilnikov AA, Ovcharenko TA, Terentyev AYu, Mishurinskaya EA. Variable anatomy of facial muscles in the light of botulinum toxin injections. Plastic Surgery and Aesthetic Medicine. 2022;(4):102‑119. (In Russ., In Engl.)
https://doi.org/10.17116/plast.hirurgia2022041102

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References:

  1. Kolgunenko II. Osnovy gerontokosmetologii. M.: Meditsina; 1974. (In Russ.).
  2. Barsukov AN, Shapovalova EYu, Yunsi GA, Dyachenko EA, Osobennosti gistogeneza tverdykh i myagkikh tkanej chelyustno-litsevogo apparata cheloveka na 5-j nedele embriogeneza. World of Medicine and Biology. 2009; 3:64-67. (In Russ.).
  3. Le Louarn C, Buthiau D, Buis J. Structural aging: The facial recurve concept. Aesthetic Plast Surg. 2007;31(3):213-218.  https://doi.org/10.1007/s00266-006-0024-9
  4. Elvan Ö, Bobuş Örs A, Tezer MS. Anatomical Evaluation of Zygomaticus Major Muscle With Relation to Orbicularis Oculi Muscle and Parotid Duct. J Craniofac Surg. 2020;31(6):1844-1847. https://doi.org/10.1097/SCS.0000000000006396
  5. Hur MS, Hu KS, Park JT, Youn KH, Kim HJ. New anatomical insight of the levator labii superioris alaeque nasi and the transverse part of the nasalis. Surg Radiol Anat. 2010;32(8):753-756.  https://doi.org/10.1007/s00276-010-0679-4
  6. Ebrahimi A, Nejadsarvari N, Motamedi MH, Rezaee M, Koushki ES. Anatomic variations found on dissection of depressor septi nasi muscles in cadavers. Arch Facial Plast Surg. 2012;14(1):31-33.  https://doi.org/10.1001/archfacial.2011.1216
  7. Cosmetic Neurotoxin Market Study. Medical Insight, Inc. 2022.
  8. Kerscher M, Fabi S, Fischer T, Gold M, Joseph J, Prager W, Rzany B, Yoelin S, Roll S, Klein G, Maas C. IncobotulinumtoxinA Demonstrates Safety and Prolonged Duration of Effect in a Dose-Ranging Study for Glabellar Lines. JDD, 01 Oct 2021;20(10):1052-1060. https://doi.org/10.36849/jdd.6377
  9. Gosudarstvennyj reestr lekarstvennykh sredstv [Elektronnyj resurs]. https://grls.rosminzdrav.ru
  10. Kerscher M, Roll S, Becker A, Wigger-Alberti W. Comparison of the spread of three botulinum toxin type A preparations. Arch Dermatol Res. 2012; 304(2):155-161.  https://doi.org/10.1007/s00403-011-1179-z
  11. Carr WW, Jain N, Sublett JW. Immunogenicity of Botulinum Toxin Formulations: Potential Therapeutic Implications. Adv Ther. 2021;38(10):5046-5064. https://doi.org/10.1007/s12325-021-01882-9
  12. Park JY, Corduff N, Frevert J, Wanitphakdeedecha R, Chao YYY. Immunogenicity Associated with Aesthetic Botulinumtoxin A: A Survey of  Asia-Pacific Physicians’ Experiences and Recommendations. Plast Reconstr Surg Glob Open. 2022;10(4):e4217. https://doi.org/10.1097/GOX.0000000000004217
  13. Rappl T, Parvizi D, Friedl H, Wiedner M, May S, Kranzelbinder B, Wurze P, Hellbom B. Onset and duration of effect of incobotulinumtoxinA, onabotulinumtoxinA, and abobotulinumtoxinA in the treatment of glabellar frown lines: A randomized, double-blind study. Clin Cosmet Investig Dermatol. 2013;6:211-219.  https://doi.org/10.2147/CCID.S41537
  14. Dressler D, Saberi FA, Kollewe K, Schrader C. Safety aspects of incobotulinumtoxinA high-dose therapy. J Neural Transm (Vienna). 2015;122(2): 327-333.  https://doi.org/10.1007/s00702-014-1252-9
  15. Kane MA, Gold MH, Coleman WP 3rd, Jones DH, Tanghetti EA, Alster TS, Rohrer TE, Burgess CM, Shamban AT, Finn E. A Randomized, Double-Blind Trial to Investigate the Equivalence of IncobotulinumtoxinA and OnabotulinumtoxinA for Glabellar Frown Lines. Dermatol Surg. 2015;41(11): 1310-1319. https://doi.org/10.1097/DSS.0000000000000531
  16. Lee JH, Park JH, Lee SK, Han KH, Kim SD, Yoon CS, Park JY, Lee JH, Yang JM, Lee JH. Efficacy and safety of incobotulinum toxin A in periocular rhytides and masseteric hypertrophy: side-by-side comparison with onabotulinum toxin A. J Dermatolog Treat. 2014;25(4):326-330.  https://doi.org/10.3109/09546634.2013.769041
  17. Levy PM. The ‘Nefertiti lift’: A new technique for specific re-contouring of the jawline. J Cosmet Laser Ther. 2007;9(4):249-252.  https://doi.org/10.1080/14764170701545657
  18. Moers-Carpi M, Dirschka T, Feller-Heppt G, Hilton S, Hoffmann K, Philipp-Dormston WG, Rütter A, Tan K, Chapman MA, Fulford-Smith A. A randomised, double-blind comparison of 20 units of onabotulinumtoxinA with 30 units of incobotulinumtoxinA for glabellar lines. J Cosmet Laser Ther. 2012;14(6):296-303.  https://doi.org/10.3109/14764172.2012.738913
  19. Moradi A, Shirazi A. A Retrospective and Anatomical Study Describing the Injection of Botulinum Neurotoxins in the Depressor Anguli Oris. Plast Reconstr Surg. 2022;149(4):850-857.  https://doi.org/10.1097/PRS.0000000000008967
  20. Muti G, Harrington L. A prospective rater- and subject-blinded study comparing the efficacy of incobotulinumtoxinA and onabotulinumtoxinA to treat crow’s feet: A clinical crossover evaluation. Dermatol Surg. 2015;41(Suppl 1): 39-46.  https://doi.org/10.1097/DSS.0000000000000262
  21. Prager W, Rappl T. Phase IV study comparing incobotulinumtoxinA and onabotulinumtoxinA using a 1:1.5 dose-conversion ratio for the treatment of glabellar frown lines. J Cosmet Dermatol. 2012;11(4):267-271.  https://doi.org/10.1111/jocd.12001
  22. Prager W, Wissmüller E, Kollhorst B, Williams S, Zschocke I. Comparison of two botulinum toxin type A preparations for treating crow’s feet: A split-face, double-blind, proof-of-concept study. Dermatol Surg. 2010;36(Suppl 4): 2155-2160. https://doi.org/10.1111/j.1524-4725.2010.01798.x
  23. Sattler G, Callander MJ, Grablowitz D, Walker T, Bee EK, Rzany B, Flynn TC, Carruthers A. Noninferiority of incobotulinumtoxinA, free from complexing proteins, compared with another botulinum toxin type A in the treatment of glabellar frown lines. Dermatol Surg. 2010;36(Suppl 4):2146-2154. https://doi.org/10.1111/j.1524-4725.2010.01706.x
  24. Saybel A, Artemenko A, Nikitin S, Kurenkov A. A Prospective, Neurophysiologic Comparative Study to Assess the Efficacy and Duration of Effect of IncobotulinumtoxinA and AbobotulinumtoxinA in the Treatment of Crow’s Feet. J Drugs Dermatol. 2015;14(11):1291-1296. PMID: 26580879.
  25. Yutskovskaya YaA, Gubanova EI, Khrustaleva IE, Atamanov VV, Saybel AV, Parsagashvili EZ, Dmitrieva IP, Sanches EA, Lapatina NG, Korolkova TN, Saromytskaya AN, Goltsova EN, Satardinova EE. Konsensusnye rekomendatsii: Kseomin v esteticheskoj praktike. Metamorfozy. 2016;14:81-86. (In Russ.).
  26. Rauso R, Lo Giudice G, Tartaro G, Zerbinati N, Nicoletti GF, Fragola R. Botulinum toxin type A injections for masticatory muscles hypertrophy: A systematic review. J Craniomaxillofac Surg. 2022;50(1):7-18.  https://doi.org/10.1016/j.jcms.2021.09.019
  27. De Sanctis Pecora C, Shitara D. Botulinum Toxin Type A to Improve Facial Symmetry in Facial Palsy: A Practical Guideline and Clinical Experience. Toxins (Basel). 2021;13(2):159.  https://doi.org/10.3390/toxins13020159
  28. Sundaram H, Huang PH, Hsu NJ, Huh CH, Wu WT, Wu Y, Cassuto D, Kerscher MJ, Seo KK; Pan-Asian Aesthetics Toxin Consensus Group. Aesthetic Applications of Botulinum Toxin A in Asians: An International, Multidisciplinary, Pan-Asian Consensus. Plast Reconstr Surg Glob Open. 2016; 4(12):e872. https://doi.org/10.1097/GOX.0000000000000507
  29. Trévidic P, Sykes J, Criollo-Lamilla G. Anatomy of the Lower Face and Botulinum Toxin Injections. Plast Reconstr Surg. 2015;136(5 Suppl):84-91.  https://doi.org/10.1097/PRS.0000000000001787
  30. Hwang K, Kim JY, Lim JH. Anatomy of the Platysma Muscle. J Craniofac Surg. 2017;28(2):539-542.  https://doi.org/10.1097/SCS.0000000000003318
  31. Sharova AA. Mimic patterns of the lower third of the face and botulinum therapy for facial contour correction. Plastic Surgery and Aesthetic Medicine. 2020;(4):41-51. (In Russ.).

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