Experimental justification of the use of a new bioengineered transplant for the plastic surgery of hernial defects of the anterior abdominal wall

Chernykh A.V.; Magomedrasulova A.A.; Shevtsov A.N.; Pulver A.Yu.; Shcherbakova V.A.; Abasov A.R.; Cherkasov A.A.

doi:https://doi.org/10.17116/operhirurg2024804239

Chernykh A.V.

BurdenkoVoronezh State Medical University

ORCID: 0000-0002-6281-0020

Magomedrasulova A.A.

BurdenkoVoronezh State Medical University

ORCID: 0000-0002-3158-1480

Shevtsov A.N.

BurdenkoVoronezh State Medical University

ORCID: 0000-0001-8641-2847

Pulver A.Yu.

Institute of Biology of Aging LLC

ORCID: 0000-0001-6673-1859

Shcherbakova V.A.

BurdenkoVoronezh State Medical University

ORCID: 0000-0002-0410-4355

Abasov A.R.

BurdenkoVoronezh State Medical University

ORCID: 0000-0003-2135-6906

Cherkasov A.A.

BurdenkoVoronezh State Medical University

ORCID: 0000-0001-8355-3644

Experimental justification of the use of a new bioengineered transplant for the plastic surgery of hernial defects of the anterior abdominal wall

Authors:

Chernykh A.V., Magomedrasulova A.A., Shevtsov A.N., Pulver A.Yu., Shcherbakova V.A., Abasov A.R., Cherkasov A.A.

More about the authors

Journal: Russian Journal of Operative Surgery and Clinical Anatomy. 2024;8(4‑2): 39‑44

DOI: 10.17116/operhirurg2024804239

Read: 627 times

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To cite this article:

Chernykh AV, Magomedrasulova AA, Shevtsov AN, Pulver AYu, Shcherbakova VA, Abasov AR, Cherkasov AA. Experimental justification of the use of a new bioengineered transplant for the plastic surgery of hernial defects of the anterior abdominal wall. Russian Journal of Operative Surgery and Clinical Anatomy. 2024;8(4‑2):39‑44. (In Russ.)
https://doi.org/10.17116/operhirurg2024804239

Подписка 2026 Оперативная хирургия и клиническая анатомия (Пироговский научный журнал) (Russian Journal of Operative Surgery and Clinical Anatomy)

Использование инфографики авторами научных работ

OBJECTIVE

To study the possibility of using a new original bioengineered graft for the repair of hernial defects of the anterior abdominal wall.

MATERIAL AND METHODS

In the work, first, a new bioengineered transplant was obtained by decellularization with a 2% solution of sodium dodecyl sulfate (SDS) during rabbit autopsy, then its implantation into a simulated defect of the anterior abdominal wall of rats was performed, after which the general and local reaction of the body of experimental animals to the implant was studied on the 3rd, 7th, 14th, 30th and 180th days after surgery. A simple medium polypropylene mesh was used as a comparison.

RESULTS

When studying the local reaction of the body to the implantation of a biotransplant or polypropylene mesh into the anterior abdominal wall, it was noted that the postoperative period in experimental animals was almost identical. There were no signs of biotransplant rejection in all operated animals at the selected follow-up periods.

CONCLUSION

The results of the use of a bioengineered graft decellularized with a 2% solution of sodium dodecyl sulfate in the plastic of hernial defects of the anterior abdominal wall have been studied and described.

Keywords:

external life hernias

plastic surgery of hernial orifices

mesh implant

decellularization

bioengineered transplant

sodium dodecyl sulfate

Authors:

Chernykh A.V.

BurdenkoVoronezh State Medical University

ORCID: 0000-0002-6281-0020

Magomedrasulova A.A.

BurdenkoVoronezh State Medical University

ORCID: 0000-0002-3158-1480

Shevtsov A.N.

BurdenkoVoronezh State Medical University

ORCID: 0000-0001-8641-2847

Pulver A.Yu.

Institute of Biology of Aging LLC

ORCID: 0000-0001-6673-1859

Shcherbakova V.A.

BurdenkoVoronezh State Medical University

ORCID: 0000-0002-0410-4355

Abasov A.R.

BurdenkoVoronezh State Medical University

ORCID: 0000-0003-2135-6906

Cherkasov A.A.

BurdenkoVoronezh State Medical University

ORCID: 0000-0001-8355-3644

Received:

21.05.2024

Accepted:

13.06.2024

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References:

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