Oral enteral nutrition as a component of maintenance therapy in cancer patients

Gameeva E.V.; Dmitriev A.V.; Khoronenko V.E.; Shestopalov A.E.

doi:https://doi.org/10.17116/onkolog2020906186

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Abstract:

The consequences of malnutrition in cancer patients lead to decreases in the efficiency of treatments (surgery, chemotherapy, and radiotherapy) and survival rates and to an increase in treatment costs. In accordance with international and Russian guidelines, timely correction of the nutritional status with high-protein oral nutritional formulas supplemented by pharmaconutrients is regarded as an optimal component of maintenance therapy for cancers. The paper reviews the results of recent studies investigating the clinical use of high-energy, high-protein oral nutritional formulas and pharmacological nutrients for the prevention and treatment of a number of chemo- and radiotherapy-induced complications (mucositis, esophagitis, and enteritis) in cancer patients, as well as modern international nutritional support guidelines for cancer patients. In most randomized clinical trials, the use of high-energy, high-protein nutritional formulas in combination with pharmacological nutrients, such as glutamine and omega-3 fish oil fatty acids, can reduce the severity and duration of mucositis, esophagitis and enteritis, which are caused by their chemical and radiation effects on organs and body systems. This protective effect of combined nutritional support can reduce nutritional deficiencies and metabolic disorders, accelerate patient recovery after the end of treatment cycles, decrease hospital stay and a need for re-treatment cycles, and reduce complications and mortality.

Keywords:

malnutrition in cancer patients

correction of nutritional status

high-energy

high-protein oral nutritional formulas

glutamine

omega-3 fish oil fatty acids

Authors:

Gameeva E.V.

Herzen Moscow Oncology Research Institute — Branch Campus of the National Medical Radiology Research Center

Dmitriev A.V.

North-Western Association for Parenteral and Enteral Nutrition

ORCID: 0000-0001-6975-6103

Khoronenko V.E.

P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Radiology Research Center

Shestopalov A.E.

National Association for Clinical Nutrition and Metabolism;
Peoples’ Friendship University of Russia

Received:

25.09.2020

Accepted:

30.09.2020

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References:

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