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Zibirov R.F.

A.F. Tsyb Medical Radiology Research Center, Branch, National Medical Radiology Research Center, Ministry of Health of the Russia, Obninsk, Kaluga Region, Russia

Mozerov S.A.

A.F. Tsyb Medical Radiology Research Center, Branch, National Medical Radiology Research Center, Ministry of Health of the Russian Federation, Obninsk, Russia

Characterization of the tumor cell microenvironment

Authors:

Zibirov R.F., Mozerov S.A.

More about the authors

Journal: P.A. Herzen Journal of Oncology. 2018;7(2): 67‑72

DOI: 10.17116/onkolog20187267-72

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Table of contents

CHARACTERIZATION OF THE TUMOR CELL MICROENVIRONMENT
CHARACTERIZATION OF THE TUMOR CELL MICROENVIRONMENT

To cite this article:

Zibirov RF, Mozerov SA. Characterization of the tumor cell microenvironment. P.A. Herzen Journal of Oncology. 2018;7(2):67‑72. (In Russ.)
https://doi.org/10.17116/onkolog20187267-72

Подписка 2026 Онкология. Журнал им. П.А. Герцена (P.A. Herzen Journal of Oncology)
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Abstract:

A detailed understanding of the mechanisms for interaction of the cells of a tumor and its microenvironment opens up broad prospects for diagnosis and treatment. This review shows the role of the cellular microenvironment in carcinogenesis. The cells of the tumor microenvironment through cell-cell interaction, by secreting cytokines, growth factors, inhibitors, and through other mechanisms may contribute to the progression and growth of a tumor or its regression. The paper considers in detail the role of lymphocytes, tumor-associated macrophages and fibroblasts, neutrophils and eosinophils, as well as mast cells as an example of the tumor microenvironment.

Keywords:

tumor
tumor microenvironment
cell-cell interactions

Authors:

Zibirov R.F.

A.F. Tsyb Medical Radiology Research Center, Branch, National Medical Radiology Research Center, Ministry of Health of the Russia, Obninsk, Kaluga Region, Russia

Mozerov S.A.

A.F. Tsyb Medical Radiology Research Center, Branch, National Medical Radiology Research Center, Ministry of Health of the Russian Federation, Obninsk, Russia

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