Possibilities for surgical treatment in patients with von Hippel—Lindau syndrome

Alekseev B.Ia.; Kalpinskiĭ A.S.; Isaev A.R.; Moskvina L.V.; Niushko K.M.; Vorob'ev N.V.; Kaprin A.D.

doi:https://doi.org/

Alekseev B.Ia.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii

Kalpinskiĭ A.S.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossiii

Isaev A.R.

P.A. Herzen Moscow Oncology Research Institute, Ministry of Health of Russia ,3, Second Botkinsky Proezd, Moscow 125284, Russian Federation

Moskvina L.V.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii

Niushko K.M.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdravsotsrazvitiia Rossii

Vorob'ev N.V.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im P.A. Gertsena"

Kaprin A.D.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii

SPIN RSCI: 1759-8101
Scopus AuthorID: 6602709853
ResearcherID: K-1445-2014
ORCID: 0000-0001-8784-8415

Possibilities for surgical treatment in patients with von Hippel—Lindau syndrome

Authors:

Alekseev B.Ia., Kalpinskiĭ A.S., Isaev A.R., Moskvina L.V., Niushko K.M., Vorob'ev N.V., Kaprin A.D.

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Journal: P.A. Herzen Journal of Oncology. 2014;3(5): 57‑60

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To cite this article:

Alekseev BIa, Kalpinskiĭ AS, Isaev AR, Moskvina LV, Niushko KM, Vorob'ev NV, Kaprin AD. Possibilities for surgical treatment in patients with von Hippel—Lindau syndrome. P.A. Herzen Journal of Oncology. 2014;3(5):57‑60. (In Russ.)

Подписка 2026 Онкология. Журнал им. П.А. Герцена (P.A. Herzen Journal of Oncology)

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Abstract:

There is an annual increase in the incidence of renal cell carcinoma (RCC). The pathogenesis of clear cell RCC is associated with the loss of von Hippel—Lindau (VHL) suppressor gene activity in 65%. Hereditary RCC is one of the manifestations of VHL syndrome. The latter is an autosomal dominant condition that predisposes to benign and malignant tumors in the family. It results from a mutation in the VHL tumor suppressor gene on the short arm of chromosome 3. RCC is a leading cause of death in patients with VHL syndrome. This paper describes a case of surgical treatment in a female patient with VHL syndrome and 4 tumors in the solitary horseshoe kidney.

Keywords:

multiple primary cancer

renal cell carcinoma

von Hippel-Lindau syndrome

Authors:

Alekseev B.Ia.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii

Kalpinskiĭ A.S.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossiii

Isaev A.R.

P.A. Herzen Moscow Oncology Research Institute, Ministry of Health of Russia ,3, Second Botkinsky Proezd, Moscow 125284, Russian Federation

Moskvina L.V.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii

Niushko K.M.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdravsotsrazvitiia Rossii

Vorob'ev N.V.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im P.A. Gertsena"

Kaprin A.D.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii

SPIN RSCI: 1759-8101
Scopus AuthorID: 6602709853
ResearcherID: K-1445-2014
ORCID: 0000-0001-8784-8415

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