Identification of dengue infection markers in patients after visiting to dengue endemic countries

Ternovoi V.A.; Plyasunova I.V.; Sementsova A.O.; Kartashov M.Yu.; Shvalov A.N.; Chausov E.V.; Eremeeva L.I.; Protopopova E.V.; Chub E.V.; Bayandin R.B.; P’yankov O.V.; Loktev V.B.; Agafonov A.P.; Maksyutov R.A.

doi:https://doi.org/10.17116/molgen201937031140

Ternovoi V.A.

FBUN State Research Center of Virology and Biotechnology «Vector», Rospotrebnadzor, Koltsovo, Novosibirsk Region, Russia, 630559

Plyasunova I.V.

State Research Center of Virology and Biotechnology 'Vector' Rospotrebnadzor, Novosibirsk region, Koltsovo, Russia, 630559

Sementsova A.O.

State Research Center of Virology and Biotechnology 'Vector' Rospotrebnadzor, Novosibirsk region, Koltsovo, Russia, 630559

Kartashov M.Yu.

State Research Center of Virology and Biotechnology 'Vector' Rospotrebnadzor, Novosibirsk region, Koltsovo, Russia, 630559

Shvalov A.N.

FBUN State Research Center of Virology and Biotechnology «Vector», Rospotrebnadzor, Koltsovo, Novosibirsk Region, Russia, 630559

Chausov E.V.

State Research Center of Virology and Biotechnology 'Vector' Rospotrebnadzor, Novosibirsk region, Koltsovo, Russia, 630559

Eremeeva L.I.

State Research Center of Virology and Biotechnology 'Vector' Rospotrebnadzor, Novosibirsk region, Koltsovo, Russia, 630559

Protopopova E.V.

State Research Center of Virology and Biotechnology 'Vector' Rospotrebnadzor, Novosibirsk region, Koltsovo, Russia, 630559

Chub E.V.

State Research Center of Virology and Biotechnology «Vector», 630559, Koltsovo, Russia

Bayandin R.B.

State Research Center of Virology and Biotechnology 'Vector' Rospotrebnadzor, Novosibirsk region, Koltsovo, Russia, 630559

P’yankov O.V.

State Research Center of Virology and Biotechnology 'Vector' Rospotrebnadzor, Novosibirsk region, Koltsovo, Russia, 630559

Loktev V.B.

State Research Center of Virology and Biotechnology «Vector», Koltsovo, 630559, Novosibirsk, Russia

Agafonov A.P.

State Research Center of Virology and Biotechnology 'Vector' Rospotrebnadzor, Novosibirsk region, Koltsovo, Russia, 630559

Maksyutov R.A.

State Research Center of Virology and Biotechnology 'Vector' Rospotrebnadzor, Novosibirsk region, Koltsovo, Russia, 630559

Identification of dengue infection markers in patients after visiting to dengue endemic countries

Authors:

Ternovoi V.A., Plyasunova I.V., Sementsova A.O., Kartashov M.Yu., Shvalov A.N., Chausov E.V., Eremeeva L.I., Protopopova E.V., Chub E.V., Bayandin R.B., P’yankov O.V., Loktev V.B., Agafonov A.P., Maksyutov R.A.

More about the authors

Journal: Molecular Genetics, Microbiology and Virology. 2019;37(3): 140‑148

DOI: 10.17116/molgen201937031140

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To cite this article:

Ternovoi VA, Plyasunova IV, Sementsova AO, et al. . Identification of dengue infection markers in patients after visiting to dengue endemic countries. Molecular Genetics, Microbiology and Virology. 2019;37(3):140‑148. (In Russ.)
https://doi.org/10.17116/molgen201937031140

Подписка 2026 Молекулярная генетика, микробиология и вирусология (Molecular Genetics, Microbiology and Virology)

Использование инфографики авторами научных работ

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Abstract:

One or more markers of dengue infection such as viral RNA, NS1 antigen, IgM, or IgG antibody were detected in sera from Russian patients hospitalized with suspected dengue fever. The joint using of immunological and genetic methods is only provided a more effective diagnostics for dengue infection. The IgG against dengue virus has been detected in patients with high level IgG against tick-borne encephalitis virus (TBEV) and the contrary the IgG to TBEV has also been detected in patients with high titers of IgG to dengue virus. The obtained results are confirmed the antigenic cross-reactivity between different species of flaviviruses. These may be inducing problems for using enzyme immunoassay for detection TBEV and dengue infection in patients. Genotyping of dengue virus isolates showed that imported to Russia cases of dengue infection are caused by subtypes 1-4 of the dengue virus with a prevalence of dengue 1 infection. Sequencing of these virus isolates showed that the isolates are phylogenetically similar to modern dengue virus variants from the countries of Southeast Asia.

Keywords:

dengue virus

antibodies

enzyme immunoassay

tick-borne encephalitis virus

Authors:

Ternovoi V.A.

FBUN State Research Center of Virology and Biotechnology «Vector», Rospotrebnadzor, Koltsovo, Novosibirsk Region, Russia, 630559

Plyasunova I.V.

State Research Center of Virology and Biotechnology 'Vector' Rospotrebnadzor, Novosibirsk region, Koltsovo, Russia, 630559

Sementsova A.O.

State Research Center of Virology and Biotechnology 'Vector' Rospotrebnadzor, Novosibirsk region, Koltsovo, Russia, 630559

Kartashov M.Yu.

State Research Center of Virology and Biotechnology 'Vector' Rospotrebnadzor, Novosibirsk region, Koltsovo, Russia, 630559

Shvalov A.N.

FBUN State Research Center of Virology and Biotechnology «Vector», Rospotrebnadzor, Koltsovo, Novosibirsk Region, Russia, 630559

Chausov E.V.

State Research Center of Virology and Biotechnology 'Vector' Rospotrebnadzor, Novosibirsk region, Koltsovo, Russia, 630559

Eremeeva L.I.

State Research Center of Virology and Biotechnology 'Vector' Rospotrebnadzor, Novosibirsk region, Koltsovo, Russia, 630559

Protopopova E.V.

State Research Center of Virology and Biotechnology 'Vector' Rospotrebnadzor, Novosibirsk region, Koltsovo, Russia, 630559

Chub E.V.

State Research Center of Virology and Biotechnology «Vector», 630559, Koltsovo, Russia

Bayandin R.B.

State Research Center of Virology and Biotechnology 'Vector' Rospotrebnadzor, Novosibirsk region, Koltsovo, Russia, 630559

P’yankov O.V.

State Research Center of Virology and Biotechnology 'Vector' Rospotrebnadzor, Novosibirsk region, Koltsovo, Russia, 630559

Loktev V.B.

State Research Center of Virology and Biotechnology «Vector», Koltsovo, 630559, Novosibirsk, Russia

Agafonov A.P.

State Research Center of Virology and Biotechnology 'Vector' Rospotrebnadzor, Novosibirsk region, Koltsovo, Russia, 630559

Maksyutov R.A.

State Research Center of Virology and Biotechnology 'Vector' Rospotrebnadzor, Novosibirsk region, Koltsovo, Russia, 630559

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