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Baranova E.D.

Kemerovo State University, 650000, Kemerovo, Russia

Druzhinin V.G.

Kemerovo State University, 650000, Kemerovo, Russia

The human bacterial microflora composition: genotoxic and carcinogeneous effects associated with its changes in various organs

Authors:

Baranova E.D., Druzhinin V.G.

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Journal: Molecular Genetics, Microbiology and Virology. 2019;37(2): 58‑63

DOI: 10.17116/molgen20193702158

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Baranova ED, Druzhinin VG. The human bacterial microflora composition: genotoxic and carcinogeneous effects associated with its changes in various organs. Molecular Genetics, Microbiology and Virology. 2019;37(2):58‑63. (In Russ.)
https://doi.org/10.17116/molgen20193702158

 
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Abstract The bacterial microflora that inhabits our body makes up the most complex microbial community called microbiota. The microbiota, which is evolutionarily fixed in the human body, has a significant effect on the maintenance of human health and functions. To date, the study of the genotoxic potential of microflora, closely related to bacterial oncogenesis, remains without proper attention. When the imbalance of healthy microflora is violated under the influence of various factors, including mutagens and environmental carcinogens, the composition of the microbiota is transformed into an «aggressive» form. There are suggestions that such changes lead to functional metabolism shifts in bacterial communities, which leads to a progression of malignant growth in these parts of the host organism. Bacteria are able to influence pathogenetic processes occurring during the course of the disease, producing effectors of DNA damage in the cells of the host organism or modifying the body’s ability to metabolize mutagens and carcinogens. In this review, we present evidence and hypotheses about the ability of pathogenic and commensal bacteria with genotoxic potential to lead to the development of oncological diseases. The review examines individual organs (intestines, stomach, respiratory tract, gallbladder and mammary gland), in the carcinogenesis of which the influence of bacteria that can damage the DNA of the host cells is known.

Keywords:

human microbiota composition
bacterial genotoxins
DNA damages
mutagenesis
carcinogenesis

Authors:

Baranova E.D.

Kemerovo State University, 650000, Kemerovo, Russia

Druzhinin V.G.

Kemerovo State University, 650000, Kemerovo, Russia

List of references:

  1. Shui W, Gilmore SA, Sheu L, Liu J, Keasling JD, Bertozzi CR. Quantitative Proteomic Profiling of Host — Pathogen interactions: The Macrophage Response to Mycobacterium tuberculosis Lipids. J Proteome Res. 2009;8(1):282-289.
  2. Druzhinin VG, Matskova LV, Fucic A. Induction and modulation of genotoxicity by the bacteriome in mammals. Mutat Res. 2018;776:70-77.
  3. Nougayrède JP, Homburg S, Taieb F, Boury M, Brzuszkiewicz E, Gottschalk G, et al. Escherichia coli induces DNA double-strand breaks in eukaryotic cells. Science. 2006;313:848-851.
  4. Guerra L, Cortes-Bratti X, Guidi R, Frisan T. The biology of the cytolethal distending toxins. Toxins (Basel). 2011;3(3):172-190.
  5. Haghjoo E, Galan J. Salmonella typhi encodes a functional cytolethal distending toxin that is delivered into host cells by a bacterial-internalization pathway. Proc Natl Acad Sci USA. 2004;101(13):4614-4619.
  6. Nesic D, Hsu Y, Stebbins C. Assembly and function of a bacterial genotoxin. Nature. 2004;429(6990):429-433.
  7. Elwell C, Dreyfus L. DNAase I homologous residues in CdtB are critical for cytolethal distending toxin-mediated cell cycle arrest. Mol Microbiol. 2000;37(4):952-963.
  8. Frisan T, Cortes-Bratti X, Chaves-Olarte E, Stenerlöw B, Thelestam M. The Haemophilus ducreyi cytolethal distending toxin induces DNA double strand breaks and promotes ATM-dependent activation of RhoA. Cell Microbiol. 2003;5:695-707.
  9. Lemercier C. When our genome is targeted by pathogenic bacteria. Cell Mol Life Sci. 2015;72(14):2665-2676.
  10. Chumduri C, Gurumurthy RK, Zietlow R, Meyer TF. Subversion of host genome integrity by bacterial pathogens. Nat Rev Mol Cell Biol. 2016;17(10):659-673.
  11. Wang X, Yang Y, Huycke MM. Microbiome-driven carcinogenesis in colorectal cancer: Models and mechanisms. Free Radic Biol Med. 2017;105:3-15.
  12. Toprak NU, Yagci A, Gulluoglu BM, Akin ML, Demirkalem P, Celenk T, et al. A possible role of Bacteroides fragilis enterotoxin in the aetiology of colorectal cancer. Clin Microbiol Infect. 2006;12:782-786.
  13. Balamurugan R, Rajendiran E, George S, Samuel GV, Ramakrishna BS. Realtime polymerase chain reaction quantification of specific butyrate-producing bacteria, Desulfovibrio and Enterococcus faecalis in the feces of patients with colorectal cancer. J Gastroenterol Hepatol. 2008;23:1298-1303.
  14. Wroblewski LE, Peek RM, Wilson KT. Helicobacter pylori and gastric cancer: factors that modulate disease risk. Clin Microbiol Rev. 2010;23:713-739.
  15. Arthur JC, Perez-Chanona E, Mühlbauer M, Tomkovich S, Uronis JM, Fan TJ, et al. Intestinal inflammation targets cancer-inducing activity of the microbiota. Science. 2012;338:120-123.
  16. Zhou Y, He H, Xu H, Li Y, Li Z, Du Y, et al. Association of oncogenic bacteria with colorectal cancer in South China. Oncotarget. 2016;6;7(49):80794-80802.
  17. Sanapareddy N, Legge RM, Jovov B, McCoy A, Burcal L, Araujo-Perez F, et al. Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans. ISME J. 2012;6:1858-1868.
  18. Sobhani I, Tap J, Roudot-Thoraval F, Roperch JP, Letulle S, Langella P. et al. Microbial dysbiosis in colorectal cancer (CRC) patients. PLoSOne. 2011;6(1):e16393.
  19. Sears CL. Enterotoxigenic Bacteroides fragilis: a rogue among symbiotes. Clin Microbiol Rev. 2009;22(2):349-369.
  20. Goodwin AC, Destefano Shields CE, Wu S, Huso DL, Wu X, Murray-Stewart TR, et al. Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis. Proc Natl Acad Sci USA. 2011;108(37):15354-15359.
  21. Huycke M, Moore D. In vivo production of hydroxyl radical by Enterococcus faecalis colonizing the intestinal tract using aromatic hydroxylation. Free Radic Biol Med. 2002;33(6):818-826.
  22. Faïs T, Delmas J, Serres A, Bonnet R, Dalmasso G. Impact of CDT Toxin on Human Diseases. Toxins (Basel). 2016;8(7):pii: E220.
  23. Hale VL, Chen J, Johnson S, Harrington SC, Yab TC, Smyrk TC, et al. Shifts in the Fecal Microbiota Associated with Adenomatous Polyps. Cancer Epidemiol Biomarkers Prev. 2017;26(1):85-94.
  24. Marchesi JR, Dutilh BE, Hall N, Peters WH, Roelofs R, Boleij A, Tjalsma H. Towards the human colorectal cancer microbiome. PLoS One. 2011;6:e20447.
  25. Tomasello G, Tralongo P, Damiani P, Sinagra E, Di Trapani B, Zeenny MN, et al. Dismicrobism in inflammatory bowel disease and colorectal cancer: changes in response of colocytes. World J Gastroenterol. 2014;20(48):18121-18130.
  26. Maier I, Berry DM, Schiestl RH. Intestinal microbiota reduces genotoxic endpoints induced by high-energy protons. Radiat Res. 2014;181(1):45-53.
  27. Dickson RP, Erb-Downward JR, Huffnagle GB. The role of the bacterial microbiome in lung disease. Expert Rev Respir Med. 2013;7:245-257.
  28. Mao Q, Jiang F, Yin R, Wang J, Xia W, Dong G, et al. Interplay between the lung microbiome and lung cancer. Cancer Lett. 2018;415:40-48.
  29. Laroumagne S, Salinas-Pineda A, Hermant C, Murris M, Gourraud PA, Do C, et al. Incidence and characteristics of bronchial colonisation in patient with lung cancer: a retrospective study of 388 cases. Rev Mal Respir. 2011;28(3):328-335.
  30. Yan X, Yang M, Liu J, Gao R, Hu J, Li J, et al. Discovery and validation of potential bacterial biomarkers for lung cancer. Am J Cancer Res. 2015;5:3111-3122.
  31. Pragman AA, Kim HB, Reilly CS, Wendt C, Isaacson RE. The lung microbiome in moderate and severe chronic obstructive pulmonary disease. PLoS ONE. 2012;7:e47305.
  32. Lin KW, Li J, Finn PW. Emerging pathways in asthma: Innate and adaptive interactions. Biochim Biophys Acta. 2011;1810:1052-1058.
  33. Han MK, Huang YJ, Lipuma JJ, Boushey HA, Boucher RC, Cookson WO, et al. Significance of the microbiome in obstructive lung disease. Thorax. 2012;67:456-463.
  34. Sze MA, Dimitriu PA, Hayashi S, Elliott WM, McDonough JE, Gosselink JV, et al. The lung tissue microbiome in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2012;185:1073-1080.
  35. Engel M, Endesfelder D, Schloter-Hai B, Kublik S, Granitsiotis MS, Boschetto P, et al. Influence of lung CT changes in chronic obstructive pulmonary disease (COPD) on the human lung microbiome. PLoS One. 2017;12(7):e0180859.
  36. Goleva E, Jackson LP, Harris JK, Robertson CE, Sutherland ER, Hall CF, et al. The effects of airway microbiome on corticosteroid responsiveness in asthma. Am J Respir Crit Care Med. 2013;188:1193-1201.
  37. Porat R, Clark BD, Wolff SM, Dinarello CA. Enhancement of growth of virulent strains of Escherichia coli by interleukin-1. Science. 1991;254:430-432.
  38. Lyte M, Ernst S. Catecholamine induced growth of gram negative bacteria. Life Sci. 1992;50:203-212.
  39. Freestone PP, Hirst RA, Sandrini SM, Sharaff F, Fry H, Hyman S, et al. Pseudomonas aeruginosa — catecholamine inotrope interactions: a contributory factor in the development of ventilator associated pneumonia? Chest. 2012;142:1200-1210.
  40. Rai P, Parrish M, Tay IJ, Li N, Ackerman S, He F, et al. Streptococcus pneumoniae secretes hydrogen peroxide leading to DNA damage and apoptosis in lung cells. Proc Natl Acad Sci USA. 2015;112(26):3421-3430.
  41. Rai P, He F, Kwang J, Engelward BP, Chow VT, et al. Pneumococcal Pneumolysin Induces DNA Damage and Cell Cycle Arrest. Sci Rep. 2016;6:22972.
  42. Elsen S, Collin-Faure V, Gidrol X, Lemercier C. The opportunistic pathogen Pseudomonas aeruginosa activates the DNA double-strand break signaling and repair pathway in infected cells. Cell Mol Life Sci. 2013;70(22):4385-4397.
  43. Hauser A. The type III secretion system of Pseudomonas aeruginosa: Infection by injection. Nat Rev Microbiol. 2009;7(9):654-665.
  44. Al-Hebshi NN, Nasher AT, Maryoud MY, Homeida HE, Chen T, Idris AM, et al. Inflammatory bacteriome featuring Fusobacteriumnucleatum and Pseudomonas aeruginosa identified in association with oral squamous cell carcinoma. Sci Rep. 2017;7(1):1834.
  45. Cameron SJS, Lewis KE, Huws SA, Hegarty MJ, Lewis PD, Pachebat JA, et al. A pilot study using metagenomic sequencing of the sputum microbiome suggests potential bacterial biomarkers for lung cancer. PLoS One. 2017;12(5):e0177062.
  46. Vielfort K, Söderholm N, Weyler L, Vare D, Löfmark S, Aro H, et al. Neisseria gonorrhoeae infection causes DNA damage and affects the expression of p21, p27 and p53 in non-tumor epithelial cells. J Cell Sci. 2013;126(1):339-347.
  47. Fox JG, Wang TC. Inflammation, atrophy, and gastric cancer. J Clin Invest. 2007;117:60-69.
  48. Peek RMJr, Blaser MJ. Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nature Rev Cancer. 2002;2:28-37.
  49. Kim JM, Kim JS, Lee JY, Kim YJ, Youn HJ, Kim IY, et al. Vacuolatingcytotoxin in Helicobacter pylori water-soluble proteins upregulates chemokine expression in human eosinophils via Ca2+ influx, mitochondrial reactive oxygen intermediates, and NF-kappa B activation. Infect Immun. 2007;75(7):3373-3381.
  50. Arabski M, Klupinska G, Chojnacki J, Kazmierczak P, Wisniewska-Jarosinska M, Drzewoski J, et al. DNA damage and repair in Helicobacter pylori-infected gastric mucosa cells. Mutat Res. 2005;570(1):129-135.
  51. Eftang LL, Esbensen Y, Tannæs TM, Bukholm IR, Bukholm G. Interleukin-8 is the single most up-regulated gene in whole genome profiling of H. pylori exposed gastric epithelial cells. BMC Microbiol. 2012;12:9.
  52. Machado AM, Figueiredo C, Touati E, Máximo V, Sousa S, Michel V. et al. Helicobacter pylori infection induces genetic instability of nuclear and mitochondrial DNA in gastric cells. Clin Cancer Res. 2009;15(9):2995-3002.
  53. Peek RM Jr, Blaser MJ. Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nature Rev Cancer. 2002;2:28-37.
  54. Samaras V, Rafailidis PI, Mourtzoukou EG, Peppas G, Falagas ME. Chronic bacterial and parasitic infections and cancer: a review. J Infect Dev Ctries. 2010;4:267-281.
  55. Nagaraja V, Eslick GD. Systematic review with meta-analysis: the relationship between chronic Salmonella typhi carrier status and gallbladder cancer. Aliment Pharmacol Ther. 2014;39(8):745-750.
  56. Zhou D, Wang JD, Weng MZ, Zhang Y, Wang XF, Gong W, et al. Infections of Helicobacter spp. in the biliary system are associated with biliary tract. Eur J Gastroenterol Hepatol. 2013;25(4):447-454.
  57. Fukuda K, Kuroki T, Tajima Y, Tsuneoka N, Kitajima T, Matsuzaki S, et al. Comparative analysis of Helicobacter DNAs and biliary pathology in patients with and without hepatobiliary cancer. Carcinogenesis. 2002;23(11):1927-1931.
  58. Murphy G, Michel A, Taylor PR, Albanes D, Weinstein SJ, Virtamo J, et al. Association of seropositivity to Helicobacter species and biliary tract cancer in the ATBC study. Hepatology. 2014;60(6):1963-1971.
  59. Urbaniak C, Gloor GB, Brackstone M, Scott L, Tangney M, Reid G. The Microbiota of Breast Tissue and Its Association with Breast Cancer. Appl Environ Microbiol. 2016;82(16):5039-5048.

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