Annual biological variation and personalized reference intervals of clinical chemistry and hematology analytes

Wang S.; Zhao M.; Su Z.; Mu R.

doi:https://doi.org/10.17116/labs20231202151

Wang S.

Zhao M.

Su Z.

Mu R.

Annual biological variation and personalized reference intervals of clinical chemistry and hematology analytes

Authors:

Wang S., Zhao M., Su Z., Mu R.

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Journal: Laboratory Service. 2023;12(2): 51‑64

DOI: 10.17116/labs20231202151

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To cite this article:

Wang S, Zhao M, Su Z, Mu R. Annual biological variation and personalized reference intervals of clinical chemistry and hematology analytes. Laboratory Service. 2023;12(2):51‑64. (In Russ.)
https://doi.org/10.17116/labs20231202151

Подписка 2025 Лабораторная служба (Laboratory Service)

Использование инфографики авторами научных работ

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OBJECTIVE

A large number of people undergo annual health checkup but accurate laboratory criterion for evaluating their health status is limited. The present study determined annual biological variation (BV) and derived parameters of common laboratory analytes in order to accurately evaluate the test results of the annual health-care population.

MATERIAL AND METHODS

A total of 43 healthy individuals who had regular healthcare once a year for six consecutive years, were enrolled using physical, electrocardiogram, ultrasonography and laboratory. The annual BV data and derived parameters, such as reference change value (RCV) and index of individuality (II) were calculated and compared with weekly data. We used annual BV and homeostatic set point to calculate personalized reference intervals (RI_per) which were compared with population-based reference intervals (RI_pop).

RESULTS

We have established the annual within-subject BV (CV_I), RCV, II, RI_per of 24 commonly used clinical chemistry and hematology analytes for healthy individuals. Among the 18 comparable measurands, CV_I estimates of annual data for 11 measurands were significantly higher than the weekly data. Approximately 50% measurands of II were <0.6, the utility of their RI_pop were limited. The distribution range of RI_per for most measurands only copied small part of RI_pop with reference range index for 8 measurands <0.5.

CONCLUSIONS

Compared with weekly BV, for annual healthcare individuals, annual BV and related parameters can provide more accurate evaluation of laboratory results. RIper based on long-term BV data is very valuable for “personalized” diagnosis on annual health assessments.

Keywords:

biological variation

index of individuality

personalized reference intervals

reference change value

reference intervals

Authors:

Wang S.

Zhao M.

Su Z.

Mu R.

Received:

21.05.2023

Accepted:

15.06.2023

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