Study of protective anti-bacterial mechanisms in children living in the conditions of exposure to emissions of the enterprise of black metallurgy

Pospelova S.V.

Perm State University of Medicine named after Academician E.A. Wagner

Horovits E.S.

Perm State University of Medicine named after Academician E.A. Wagner

Krivtsov A.V.

FBUN «Federal Scientific Center for Medical and Preventive Health Risk Management Technologies for the Population» (FBUN FNC MPT URZN)

Dolgikh O.V.

FBUN «Federal Scientific Center for Medical and Preventive Health Risk Management Technologies for the Population» (FBUN FNC MPT URZN)

Study of protective anti-bacterial mechanisms in children living in the conditions of exposure to emissions of the enterprise of black metallurgy

Authors:

Pospelova S.V., Horovits E.S., Krivtsov A.V., Dolgikh O.V.

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Journal: Laboratory Service. 2021;10(2): 22‑27

DOI: 10.17116/labs20211002122

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To cite this article:

Pospelova SV, Horovits ES, Krivtsov AV, Dolgikh OV. Study of protective anti-bacterial mechanisms in children living in the conditions of exposure to emissions of the enterprise of black metallurgy. Laboratory Service. 2021;10(2):22‑27. (In Russ.)
https://doi.org/10.17116/labs20211002122

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THE AIM OF THE STUDY

Was to assess the frequency of occurrence of the S.aureus bacteriocarrier and the state of cellular, humoral, and local immunity factors in children living under the influence of waste from the iron and steel industry.

MATERIAL AND METHODS

A total of 154 children were examined for staphylococcal bacteriocarrier, including 79 from the area polluted by metallurgical plant emissions. Indices of local, humoral and cellular immunity, phagocytic activity of neutrophils, the level of metals in serum have been studied using traditional methods.

RESULTS

In 52.2% of children living in ecologically unfavorable conditions, S. aureus was found in the nasopharynx, which is 4 times more often than in the comparison group. They also in this biotope revealed a significant decrease in the level of sIgA and lactoferrin. In the blood serum of these children against the background of increased concentration of metallopollutions (vanadium — 8.9 times; manganese — 1.8 times relative to the comparison group), a statistically significant decrease in the titer of total IgA and IgG, as well as specific IgG against S. aureus antigens. A decrease in the number of immunocompetent cells was revealed: (CD25 +, CD4 +, CD8 +, CD3 + — 1.3 times) and values of a phagocytosis indicators.

CONCLUSIONS

Among children living under the conditions of anthropogenic stress, a high proportion of S.aureus bacteria carriers had been established. Metallopollutions have a negative impact on all components of the immune system.

Keywords:

metallopollutions

staphylococcal bacteriocarrier

immunity factors

sIgA

lactoferrin

Authors:

Pospelova S.V.

Perm State University of Medicine named after Academician E.A. Wagner

Horovits E.S.

Perm State University of Medicine named after Academician E.A. Wagner

Krivtsov A.V.

FBUN «Federal Scientific Center for Medical and Preventive Health Risk Management Technologies for the Population» (FBUN FNC MPT URZN)

Dolgikh O.V.

FBUN «Federal Scientific Center for Medical and Preventive Health Risk Management Technologies for the Population» (FBUN FNC MPT URZN)

Received:

02.09.2020

Accepted:

07.02.2021

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