The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Kim D.G.

Moscow Research and Practical Center for Dermatovenereology and Cosmetology of the Moscow Healthcare Department

Kim P.I.

Sechenov First Moscow State Medical University of the Ministry of Health of Russia (Sechenov University)

Gomberg M.A.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology

Gushchin A.E.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology

Experience in the treatment of NGU in men associated with bacterial vaginosis in their sexual partners

Authors:

Kim D.G., Kim P.I., Gomberg M.A., Gushchin A.E.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2020;19(4): 520‑526

DOI: 10.17116/klinderma202019041520

Read: 15319 times

Download PDF (RU)
Contact the author
Table of contents

EXPERIENCE IN THE TREATMENT OF NGU IN MEN ASSOCIATED WITH BACTERIAL VAGINOSIS IN THEIR SEXUAL PARTNERS
EXPERIENCE IN THE TREATMENT OF NGU IN MEN ASSOCIATED WITH BACTERIAL VAGINOSIS IN THEIR SEXUAL PARTNERS

To cite this article:

Kim DG, Kim PI, Gomberg MA, Gushchin AE. Experience in the treatment of NGU in men associated with bacterial vaginosis in their sexual partners. Russian Journal of Clinical Dermatology and Venereology. 2020;19(4):520‑526. (In Russ.)
https://doi.org/10.17116/klinderma202019041520

Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Bacterial vagi­nosis: modern views. Russian Journal of Clinical Dermatology and Vene­reology. 2025;(3):261-268
Lactobacilli and bacterial vagi­nosis. Species typing and analysis of content levels in the microbiome. Mole­cular Gene­tics, Microbiology and Viro­logy. 2025;(2):43-50
Correction of vagi­nal microbiocenosis in bacterial vagi­nosis. Promising areas. Russian Bulletin of Obstetrician-Gynecologist. 2025;(4):44-50
Abstract:

RELEVANCE

After STD exclusion in more than one third of cases, it is not possible to establish the etiology of inflammation in the urethra. In such cases, any microorganisms that may be in the urethra after sexual contact, including bacteria associated with bacterial vaginosis (BV) in women, cannot be excluded as possible etiological factors of urethritis in men. NGU can negatively affect the reproductive health of both men and their sexual partners — women.

OBJECTIVE

To study the clinical efficacy of treatment of NGU in men associated with BV in their sexual partners.

MATERIAL AND METHODS

The study included 166 heterosexual men and their sexual partners (n=174) who consult a doctor for an STD. All men, after the exclusion STDs, are divided into 2 clinical groups: group 1 — with signs of urethritis, group 2 — without urethritis (control group). Within each group, 2 subgroups are distinguished, depending on the presence or absence of BV in their sexual partners. Men with urethritis and their sexual partners with positive BV status were treated with clindamycin or nifurathel, and men with urethritis and their sexual partners with negative BV status were treated with doxycycline.

RESULTS

The efficacy of clindamycin, nifuratel and doxycycline was 81.2%, 84% and 75%, respectively. The least amount of side effects associated with the gastrointestinal tract, skin rashes and headaches, was noted after the use of nifuratel.

CONCLUSION

Treatment of patients with NGU and their sexual partners with positive BV status with clindamycin and nifurathel showed high therapeutic efficacy, more than, nifuratel showing a higher safety profile. This examination algorithm with subsequent administration of etiotropic therapy helps to avoid administration of empirical antimicrobial therapy in the treatment of NGU associated with BV in sexual partners, and improves the effectiveness of treatment.

Keywords:

non-gonococcal urethritis
bakterial vaginosis
BV-associated bacteria
treatment of urethritis

Authors:

Kim D.G.

Moscow Research and Practical Center for Dermatovenereology and Cosmetology of the Moscow Healthcare Department

Kim P.I.

Sechenov First Moscow State Medical University of the Ministry of Health of Russia (Sechenov University)

Gomberg M.A.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology

Gushchin A.E.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology

Received:

12.03.2020

Accepted:

25.05.2020

Close metadata

References:

  1. Vivancos R, Abubakar I, Hunter PR. Foreign travel, casual sex, and sexually transmitted infections: systematic review and meta-analysis. Int J Infect Dis. 2010;14:e842-851. 
  2. Horner P. Asymptomatic men: should they be tested for urethritis? Sex Transm Infect. 2007;83:81-84. 
  3. Horner P. The Etiology of Acute Nongonococcal Urethritis-The Enigma of Idiopathic Urethritis? Sexually Transmitted Diseases. 2011;38:187-189. 
  4. Tully JG, Taylor-Robinson D, Cole RM, Rose DL. A newly discovered mycoplasma in the human urogenital tract. Lancet. 1981 June 13;1(8233):1288-1291.
  5. Lau CY, Qureshi AK. Azithromycin versus doxycycline for genital chlamydial infections: a meta-analysis of randomized clinical trials. Sex Transm Dis. 2002 Sept;29(9):497-502. 
  6. Ito S, Yasuda M, Seike K, Sugawara T, Tsuchiya T, Yokoi S, Nakano M, Deguchi T. Clinical and microbiological outcomes in treatment of men with non-gonococcal urethritis with a 100-mg twice-daily dose regimen of sitafloxacin. J Infect Chemother. 2012 June;18(3):414-418.  https://doi.org/10.1007/s10156-012-0392-9
  7. Bachir BG, Jarvi K. Infectious, inflammatory, and immunologic conditions resulting in male infertility. Urol Clin North Am. 2014;41(1):67-81.  https://doi.org/10.1016/j.ucl.2013.08.008
  8. Kamwendo F, Johansson E, Moi H, et al. Gonorrhea, genital chlamydial infection, and nonspecific urethritis in male partners of women hospitalized and treated for acute pelvic inflammatory disease. Sex Transm Dis. 1993; 20:143-146. PMID:8511708 
  9. Paavonen J, Eggert-Kruse W. Chlamydia trachomatis: impact on human reproduction. Hum Reprod Update. 1999 Sept-Oct;5(5):433-447. PMID: 10582782.
  10. Simms I, Stephenson JM. Pelvic inflammatory disease epidemiology:What do we know and what do we need to know? SexTransm Infect. 2000;76:80-87. 
  11. Frolund M, Lidbrink P, Wikstrom A, et al. Urethritis-associated Pathogens in Urine from Men with Nongonococcal Urethritis: A Case-control Study. Acta Derm Venereol. 2016 June 15;96(5):689-694. 
  12. Gaydos CA, Barnes MR, Quinn N, Jett-Goheen M, Hsieh YH. Trichomonas vaginalis infection in men who submit self-collected penile swabs after internet recruitment. SexTransm Infect. 2013;89:504-508. 
  13. Sena AC, Bachmann LH, Hobbs MM. Persistent and recurrentTrichomonas vaginalis infections: epidemiology,treatment and management considerations. Expert Rev AntiInfect Ther. 2014;12:673-685. 
  14. Bradshaw CS, Tabrizi SN, Read TR, et al. Etiologies of nongonococcal urethritis: bacteria, viruses, and the association with orogenital exposure. J Infect Dis. 2006;193:336-345. 
  15. Tabrizi SN, Ling AE, Bradshaw CS, Fairley CK, Garland SM. Human adenoviruses types associated with non-gonococcal urethritis. Sex Health. 2007 Mar;4(1):41-44. PMID:17382037.
  16. Berntsson M, Lowhagen GB, Bergstrom T, et al. Viral and bacterial aetiologies of male urethritis: findings of a high prevalence of Epstein-Barr virus. International Journal of STD & AIDS. 2010;21:191-194. 
  17. Shimada Y, Ito S, Mizutani K, Sugawara T, Seike K,Tsuchiya T, et al. Bacterial loads of Ureaplasma urealyticum contribute to development of urethritis in men. Int J STD AIDS. 2014;25:294-298. 
  18. Strauss M, Colodner R, Sagas D, Adawi A, Edelstein H, Chazan B. Detection of Ureaplasma species by a semi-quantitative PCR test in urine samples: Can it predict clinical significance? Isr Med Assoc J. 2018;1:9-13. 
  19. Wetmore CM, Manhart LE, Lowens MS, Golden MR, Whittington WLH, Xet-Mull AM, et al. Demographic, Behavioral, and Clinical Characteristics of Men With Nongonococcal Urethritis Differ by Etiology: A Case-Comparison Study. Univ Washington, Ctr AIDS & STD, Seattle, WA 98121 USA Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA Univ Washington, Dept Med, Seattle, WA USA STD Clin Publ Hlth Seattle & King Cty, Seattle. Sex Transm Dis. 2011;38:180-186. (PMC free article) (PubMed).
  20. Smith GL. Branhamella catarrhalis infection imitating gonorrhea in a man. N Engl J Med. 1987;316:1277.
  21. Abdolrasouli A, Amin A, Baharsefat M, Roushan A, Hemmati Y. Moraxella catarrhalis associated with acuteurethritis imitating gonorrhoea acquired by oral-genital contact. Int J STD AIDS. 2007;18:579-580. 
  22. Wilson AP, Wolff J, Atia W. Acute urethritis due to Neisseria meningitidis group A acquired by orogenital contact: case report. Genitourin Med. 1989;65: 122-123. 
  23. Hagman M, Forslin L, Moi H, Danielsson D. Neisseria meningitides in specimens from urogenital sites. Is increased awareness necessary? Sex Transm Dis. 1991;18:228-232. 
  24. Koroglu M, Yakupogullari Y, Aydogan F. A case of urethritis due to Streptococcus pneumoniae. Sex Transm Dis. 2007;34:1040.
  25. Sturm AW. Haemophilus influenzae and Haemophilus parainfluenzae in nongonococcal urethritis. J Infect Dis. 1986;153:165-167. 
  26. Meingassner JG, Heyworth PG.Intestinal and urogenital flagellates. Antibiot Chemother (1971). 1981;30:163-202. PMID:7259131 
  27. Licea Ventura MG, Sánchez Muñoz F, Zurita Alvarez JE, Salazar Acosta C. Presence of Entamoeba histolytica in chronic urethritis. Aten Primaria. 2005 Mar 31;35(5):269. 
  28. Muzny CA, Schwebke JR. Suspected heterosexual transmission of bacterial vaginosis without seminal fluid exposure. Sex Transm Dis. 2014;41:58-60.  https://doi.org/10.1097/OLQ.0000000000000057
  29. Liu CM, Hungate BA, Toblan AAR, Ravel J, Prodger JL, Serwadda D, Kigozi G, Galiwango RM, Nalugoda F, Kelm P, Wawer MJ, Price LB, Gray RH. Penile microbiota and female partner bacterial vaginosis in Rakai, Uganda. MBio. 2015;6(3):e00589-15.  https://doi.org/10.1128/mBio.00589-15
  30. Hillier SL, Marrazzo JM, Holmes KK. Bacterial vaginosis. In: Holmes KK, et al, eds. Sexually Transmitted Diseases. New York: McGraw-Hill, 2008: 737Y768.
  31. Fredricks DN, Fiedler TL, Marrazzo JM. Molecular identification of bacteria associated with bacterial vaginosis. N Engl J Med. 2005;353:1899Y1911.
  32. Allsworth JE. Bacterial vaginosis — race and sexual transmission: issues of causation. Sex Transm Dis. 2010 Mar;37(3):137-139.  https://doi.org/10.1097/OLQ.0b013e3181d36bdc
  33. Chico RM, Mayaud P, Ariti C, Mabey D, Ronsmans C, Chandramohan D. Prevalence of malaria and sexually transmitted and reproductive tract infections in pregnancy in sub-Saharan Africa: a systematic review. JAMA. 2012 May 16;307(19):2079-2086. https://doi.org/10.1001/jama.2012.3428
  34. Bradshaw CS, Walker J, Fairley CK, Chen MY, Tabrizi SN, Donovan B, Kaldor JM, Mc Namee K, Urban E, Walker S, Currie M, Birden H, Bowden F, Garland S, Pirotta M, Gurrin L, Hocking JS. Prevalent and incident bacterial vaginosis are associated with sexual and contraceptive behaviours in young Australian women. PLoS One. 2013;8(3):e57688. https://doi.org/10.1371/journal.pone.0057688
  35. Hiller SL, Nugent RP, Eschenbach DA, Krohn MA, GibbS RS, Martin DH, Cotch MF, Edelman R, Pastorek JG 2nd, Rao AV, et al. Association between bacterial vaginosis and preterm delivery of a low-birth-weight infant. The vaginal infection and prematurity study. N Eng J Med. 1995;333(26):1737-1742.
  36. Oakeshott P, Hay P, Hay S, Steinke F, Rink E, Kerry S. Association between bacterial vaginosis or chlamydial infection and miscarriage before 16 weeks’ gestation: prospective community based cohort study. BMJ. 2002 Dec 7;325(7376):1334.
  37. Leitich H, Kiss H. Asymptomatic bacterial vaginosis and intermediate flora as risk factors for adverse pregnancy outcome. Best Pract Res Clin Obstet Gynaecol. 2007 Jun;21(3):375-390.  https://doi.org/10.1016/j.bpobgyn.2006.12.005
  38. Fethers K, Twin J, Fairley CK, Fowkes FJI, Garland SM, Fehler G, Morton AM, Hocking JS, Tabrizi SN, Bradshaw CS. Bacterial vaginosis (BV) candidate bacteria: Associations with BV and behavioural practices in sexually-experienced and inexperienced women. PLoS One. 2012;7(2):e30633. [PMC free article] [PubMed] [Cross Ref] https://doi.org/10.1371/journal.pone.0030633
  39. Colli E, Landoni M, Parazzini F. Treatment of male partners and recurrence of bacterial vaginosis: a randomised trial. Genitourin Med. 1997;73:267-270. 
  40. Mengel MB, Berg AO, Weaver CH, et al. The effectiveness of single-dose metronidazole therapy for patients and their partners with bacterial vaginosis. J Fam Pract. 1989;28:163-171. 
  41. Vejtorp M, Bollerup AC, Vejtorp L, et al. Bacterial vaginosis: a double-blind randomized trial of the effect of treatment of the sexual partner. Br J Obstet Gynaecol. 1988;95:920-926. 
  42. Vutyavanich T, Pongsuthirak P, Vannareumol P, Ruangsri RA, Luangsook P. A randomized double-blind trial of tinidazole treatment of the sexual partners of females with bacterial vaginosis. Obstet Gynecol. 1993;82:550-554. 
  43. Manhart LE, Gillespie CW, Lowens MS, et al. Standard Treatment Regimens forNongonococcal Urethritis Have Similar but Declining Cure Rates: A Randomized Controlled Trial. Clinical Infectious Diseases. 2013;56:934-942. 
  44. Kinghorn GR, Jones BM, Chowdhury FH, Geary I. Balanoposthitis associated with Gardnerella vaginalis infection in men. Br J Vener Dis. 1982; 58:127-129. 
  45. Burdge DR, Bowie WR, Chow AW. Gardnerella vaginalis-associated balanoposthitis. Sex Transm Dis. 1986;13:159-162. 
  46. Amsel R, Totten PA, Spiegel CA, et al. Nonspecific vaginitis: diagnostic criteria and microbial and epidemiological associations. Am J Med. 1983;74:14. 
  47. Horner PJ, Blee K, Falk L, van der Meijden W, Moi H. 2016 European guideline on the management of non-gonococcal urethritis. Int J STD AIDS. 2016 Oct;27(11):928-937. 
  48. Verhelst R, Vestraelen H, Claeys G, Verschraegen G, DelangheJ, Van Simaey L, De Ganck C, Temmerman M, Vaneechoutte M. Cloning of 16S rRNA genes amplified from normal and disturbed vaginal microflora suggests a strong association between Atopobium vaginae, Gardnerella vaginalis and bacterial vaginosis. BMC Microbiol. 2004;4:16. 
  49. Swidsinki A, Mendling W, Loening-Baucke V, Ladhoff A,Swidsinki S, HalLP, Lochs H. Adherent biofilms in bacterialvaginosis. Obstet Gynecol. 2005;106:1013-1023.
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.