Experience in the treatment of NGU in men associated with bacterial vaginosis in their sexual partners

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RELEVANCE

After STD exclusion in more than one third of cases, it is not possible to establish the etiology of inflammation in the urethra. In such cases, any microorganisms that may be in the urethra after sexual contact, including bacteria associated with bacterial vaginosis (BV) in women, cannot be excluded as possible etiological factors of urethritis in men. NGU can negatively affect the reproductive health of both men and their sexual partners — women.

OBJECTIVE

To study the clinical efficacy of treatment of NGU in men associated with BV in their sexual partners.

MATERIAL AND METHODS

The study included 166 heterosexual men and their sexual partners (n=174) who consult a doctor for an STD. All men, after the exclusion STDs, are divided into 2 clinical groups: group 1 — with signs of urethritis, group 2 — without urethritis (control group). Within each group, 2 subgroups are distinguished, depending on the presence or absence of BV in their sexual partners. Men with urethritis and their sexual partners with positive BV status were treated with clindamycin or nifurathel, and men with urethritis and their sexual partners with negative BV status were treated with doxycycline.

RESULTS

The efficacy of clindamycin, nifuratel and doxycycline was 81.2%, 84% and 75%, respectively. The least amount of side effects associated with the gastrointestinal tract, skin rashes and headaches, was noted after the use of nifuratel.

CONCLUSION

Treatment of patients with NGU and their sexual partners with positive BV status with clindamycin and nifurathel showed high therapeutic efficacy, more than, nifuratel showing a higher safety profile. This examination algorithm with subsequent administration of etiotropic therapy helps to avoid administration of empirical antimicrobial therapy in the treatment of NGU associated with BV in sexual partners, and improves the effectiveness of treatment.

Keywords:

non-gonococcal urethritis

bakterial vaginosis

BV-associated bacteria

treatment of urethritis

Authors:

Kim D.G.

Moscow Research and Practical Center for Dermatovenereology and Cosmetology of the Moscow Healthcare Department

Kim P.I.

Sechenov First Moscow State Medical University of the Ministry of Health of Russia (Sechenov University)

Gomberg M.A.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology

ORCID: 0000-0002-1070-5229

Gushchin A.E.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology

ORCID: 0000-0002-0399-1167

Received:

12.03.2020

Accepted:

25.05.2020

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