RELEVANCE

Lichen sclerosus (LS) is the most common disease of the vulva. Recent studies has shown the importance of infectious and inflammatory processes in the pathogenesis of this dermatosis, in particular the human papillomavirus, which also increases the likelihood of SL transformation into squamous cell carcinoma.

THE PURPOSE

Optimization of the combined therapy method for SL of the vulva associated with papillomavirus infection of the genitals.

The study involved 86 patients with a diagnosis of SL and papillomavirus infection of the genitals (without clinical manifestations), who were randomized into 3 treatment groups. Group 1 (n=29) received standard therapy with high potency topical corticosteroids. In group 2 (n=30), simultaneously with traditional treatment, antiviral therapy (a drug preparation from a purified extract of Solanum tuberosum plant shoots) was used locally and systemically. In group 3 (n=27), lasertophoresis was used in combination with drug treatment in group 2.

RESULTS

Against the background of the treatment, good clinical results were achieved, which was expressed in the elimination of itching after 1 month of therapy and the absence of its progression after 4 months, respectively, in 18/62.1% and 22/75.9% of patients in group 1, in 25/83,3% and 26/86.7% of patients in group 2 and in 25/92.6% and 26/96.3% of patients in group 3. Positive dynamics was observed in the elimination of clinical manifestations and a decrease in their severity in all groups. A pronounced therapeutic effect with statistically significant differences in relation to the indicators before treatment and the results of therapy in groups 1 and 2 was registered in group 3.

CONCLUSION

The main clinical features of the course of SL of the vulva associated with papillomavirus infection were the presence of white spots, papulo-plaques in combination with cracks, synechiae, and disruption of the architectonics of the external genital organs. Diagnosis and treatment of papillomavirus infection with a preparation from a purified extract of the shoots of the Solanum tuberosum plant in women with SL of the vulva in combination with low-intensity laser radiation leads to a rapid and persistent reduction of itching, and a statistically significant improvement of clinical symptomatology and arrest of disease progression.