Recurrent anogenital warts: current options for the relapse prevention

Chernova N.I.; Frigo N.V.; Atabieva A.Y.; Mayorova E.M.; Bagaeva M.I.

doi:https://doi.org/10.17116/klinderma202322031316

Chernova N.I.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology

ORCID: 0000-0002-4111-6670

Frigo N.V.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology

ORCID: 0000-0001-6231-971X

Atabieva A.Y.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology

ORCID: 0000-0001-7467-7725

Mayorova E.M.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology

ORCID: 0000-0001-5942-6442

Bagaeva M.I.

Moscows regional research clinical institute n.a. M. F. Vladimirskiy

ORCID: 0000-0002-4577-1832

Recurrent anogenital warts: current options for the relapse prevention

Authors:

Chernova N.I., Frigo N.V., Atabieva A.Y., Mayorova E.M., Bagaeva M.I.

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Journal: Russian Journal of Clinical Dermatology and Venereology. 2023;22(3): 316‑322

DOI: 10.17116/klinderma202322031316

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To cite this article:

Chernova NI, Frigo NV, Atabieva AY, Mayorova EM, Bagaeva MI. Recurrent anogenital warts: current options for the relapse prevention. Russian Journal of Clinical Dermatology and Venereology. 2023;22(3):316‑322. (In Russ.)
https://doi.org/10.17116/klinderma202322031316

Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)

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OBJECTIVE

To improve the effectiveness of therapy for recurrent anogenital warts.

MATERIALS AND METHODS

The study included 32 patients with recurrent anogenital warts. They underwent a laboratory examination, including STI detection in the discharge of the urethra, cervical canal, and rectum, HPV genotyping in scrapings from the rash surface using real-time PCR, and the measurement of serum 25(OH)D. Based on the medical history, patients were referred to a gastroenterologist. According to the current clinical guidelines «Anogenital (venereal) warts,» the Solanum tuberosum complex of polysaccharides was used; according to the clinical guidelines «Diagnosis, treatment, and prevention of vitamin D deficiency in adults,» vitamin D was administered.

RESULTS

HPV genotypes 6/11 were the most common in patients with recurrent anogenital warts (19 and 10 cases, respectively). In 21 patients, coinfection with HPV was reported. A decrease in serum 25(OH)D was reported in 27 patients.

CONCLUSION

Identifying and eliminating provoking factors is essential to prevent relapse. The proposed algorithm, based on the pathogenesis of the virus infection, can significantly help in the practice of doctors with these patients. The use of a domestic antiviral and immunomodulatory drug containing the Solanum tuberosum complex of polysaccharides in the form of a solution for intravenous injection, a gel for topical use, and a spray for intimate hygiene have shown high efficiency and good tolerability and seems promising and pathogenetically justified in the complex therapy. Further research is needed to understand the provoking factors of HPV infection better.

Keywords:

sum of polysaccharides of plant shoots Solanum Tuberosum

anogenital warts

human papillomavirus

HPV

papillomavirus infection

Authors:

Chernova N.I.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology

ORCID: 0000-0002-4111-6670

Frigo N.V.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology

ORCID: 0000-0001-6231-971X

Atabieva A.Y.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology

ORCID: 0000-0001-7467-7725

Mayorova E.M.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology

ORCID: 0000-0001-5942-6442

Bagaeva M.I.

Moscows regional research clinical institute n.a. M. F. Vladimirskiy

ORCID: 0000-0002-4577-1832

Received:

20.03.2023

Accepted:

10.04.2023

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