RELEVANCE

Neurosyphilis is a topical problem of venereology due to increased prevalence and severe consequences. The problem of this pathology is the lack of clear ideas about the reasons for its late detection. Clinical and epidemiological factors affecting the incidence of neurosyphilis, as well as the effectiveness of treatment and prophylactic measures for this disease, were studied.

PURPOSE OF STUDY

To research the effect of medical, preventive and organizational measures, as well as generally recognized and age-gender risk factors on the incidence of neurosyphilis in the Rostov Oblast.

MATERIALS AND METHODS

The anamnestic data of 617 patients with neurosyphilis from the personalized base of the skin and venereologic dispensary (Rostov-on-Don) for 1999–2017 were retrospectively studied.

RESULTS

Prior to admission to the dispensary, in 27.25% of patients with neurosyphilis were previously diagnosed with pathologies of a neurological and psychiatric profile. In 14.75% of patients, neurosyphilis was suspected during medical examinations when syphilis positive serological reactions were detected. Previously, only 275 patients received treatment for syphilis: 45.82% with water-soluble penicillin and ceftriaxone, 16 and 5.46% with durant forms of penicillin and doxycycline. In 32.72% of cases, the treatment regimen for syphilis was could not be established. An anamnesis, burdened by risk factors for the development of neurosyphilis, was detected in 6.97% of patients, of which 1.13% were HIV-infected.

CONCLUSION

Based on the results of the study, it can be assumed that the main factor affecting the incidence of neurosyphilis in the Rostov Oblast is an insufficiently complete examination for syphilis at the outpatient stage of patients with a neurological and psychiatric profile. In addition, the data obtained are confirm the need for cerebrospinal fluid examination of patients with latent forms of syphilis. It was failed to establish a significant influence of the nature of the previous therapy and generally recognized risk factors, including HIV co-infection, on the incidence of neurosyphilis in the Rostov Oblast.