Kaposi’s sarcoma (KS) is the first neoplastic disease that has been described in HIV patients. Its detection in HIV-infected patients serves as a basis for establishing AIDS diagnosis. Manifestations of AIDS-related KS differ significantly from other clinical types. In the days era of the widespread use of antiretroviral therapy (ART), manifestations of KS and its incidence rate have changed, and life expectancy of people suffering from this disease has increased. Objective. The objective of the study is to assess the detection rate of HIV-infected patients with KS symptoms in the Sverdlovsk region and the influence of the plasma level of CD4+ T-lymphocytes and HIV RNA (viral load, VL) on the manifestation of SK and to analyze lethal outcomes depending on the use of ART. Material and methods. The retrospective study included 96 HIV-infected patients. The patients were divided into two groups consisting of 48 persons: the 1st group consisted of patients with AIDS-related KS and the 2nd group included patients without KS. HIV infection has been detected at the same time in both groups. We compared the values of CD4+ T-lymphocytes and VL by the time of KS diagnosis (measured within 3 months before or after the date of KS diagnosis). Results. During the period 1998—2015, the cumulative number of patients with AIDS-related KS in Sverdlovsk region was 48 cases, including 28 (58%) fatal cases. The study group was dominated by heterosexual way of HIV infection. CD4+ T-cell count below 200 cells/μl was more frequently detected in KS patients (74%), more than 350 cells/μl was significantly more frequently detected in the control group (66%). The level of VL in KS patients significantly exceeded the results in the control group. More than 100 thousand copies/ml were detected more frequently in KS patients (73%), while in the 2nd group, this value was 15.3%. The mortality rate was higher in KS patients (58%) compared to that in the control group (23%) and depended on the use of ART. Conclusion. Manifestation of KS is affected by CD4+ T-cell count and high viral load. The use of ART significantly reduces the death rate in patients with AIDS-related KS (p<0,01). Men who have sex with men (MSM) are not the main risk group for development of KS in the region.