Relevance. The problem of the treatment of patients with hypertrophic and keloid cicatricial lesions is relevant. Cicatricial deformities, especially on the face, decrease quality of life, lead to anatomical and functional dysfunctions and development of neuropsychiatric disorders. The choice of treatment depends on the duration of existence of cicatricial lesions, localization, size, presence of anatomical and functional abnormalities, and other factors. Physiotherapy is a rather effective method to be used during pathological scarring. Conservative therapy using various machine-assisted techniques early after an injury or surgical intervention allows one both to reduce the degree of subjective discomfort and the volume of scar tissue and to prevent the recurrence of pathological cicatricial lesions. Objective. To assess the clinical efficacy of the method of transdermal administration of the drug complex of proteolytic enzymes used to cure hypertrophic cicatricial skin lesions. Material and methods. Pharmaphoresis of drug fermenkol using "FarmaT.E.B Trans Epidermal Barrier Physio" device for transdermal drug administration was applied in 28 patients with keloid and hypertrophic cicatricial lesions of the face and body. The age of patients ranged from 6 to 64 years; the duration of cicatricial lesions varied from 4 months to 7.5 years. The recommended concentration of fermenkol to correct keloid and hypertrophic cicatrices is 0.5-1.0 and 0.1-0.2 mg/ml, respectively. Results. Twenty-one (75%) patients showed a good result, which included suspension of active growth, total or partial regression of cicatrices, elimination of subjective unpleasant local sensations (itching, burning, pain), color difference between the cicatrice and the adjacent tissues. Satisfactory results of treatment were achieved in 7 (25%) patients. Conclusion. Electrode pharmaphoresis of fermenkol drug using "Farma T.E.B Trans Epidermal Barrier Physio" medical device for transdermal drug administration is a new and effective medical technology for treating pathological scarring.