AP-1 transcription factor gene expression in skin sections from patients with morphea

Potekaev N.N.; Vavilov V.V.; Sobolev V.V.; Soboleva A.G.; Zolotarenko A.D.; Korsunskaia I.M.; Bruskin S.A.

doi:https://doi.org/

Potekaev N.N.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology, Moscow, Russia

Vavilov V.V.

MNPTsDK Departament zdravookhraneniia Moskvy;
Pervyĭ MGMU im. I.M. Sechenova

Sobolev V.V.

N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow

Soboleva A.G.

N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow

Zolotarenko A.D.

Institut obshcheĭ genetiki im. N.I. Vavilova RAN

Korsunskaia I.M.

Centre of Theoretical Problems of Physico-Chemical Pharmacology, Russian Academy of Sciences

Bruskin S.A.

N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow

AP-1 transcription factor gene expression in skin sections from patients with morphea

Authors:

Potekaev N.N., Vavilov V.V., Sobolev V.V., Soboleva A.G., Zolotarenko A.D., Korsunskaia I.M., Bruskin S.A.

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Journal: Russian Journal of Clinical Dermatology and Venereology. 2013;11(2): 69‑74

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To cite this article:

Potekaev NN, Vavilov VV, Sobolev VV, Soboleva AG, Zolotarenko AD, Korsunskaia IM, Bruskin SA. AP-1 transcription factor gene expression in skin sections from patients with morphea. Russian Journal of Clinical Dermatology and Venereology. 2013;11(2):69‑74. (In Russ.)

Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)

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Abstract:

The RT-PCR based quantitative analysis of AP-1 transcription factor gene expression was carried out and showed the up-regulation of the majority of AP-1 genes expression in morphea lesions. Overexpression of C-JUN, JUNB, JUND, C-FOS, FOSB and FRA-2 genes in affected skin samples was shown to be evident. FRA-1 gene expression was down-regulated in all affected skin biopsies compared with normal skin specimen.

Keywords:

scleroderma

gene expression

RT-PCR

AP-1

TGF-Β

Authors:

Potekaev N.N.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology, Moscow, Russia

Vavilov V.V.

MNPTsDK Departament zdravookhraneniia Moskvy;
Pervyĭ MGMU im. I.M. Sechenova

Sobolev V.V.

N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow

Soboleva A.G.

N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow

Zolotarenko A.D.

Institut obshcheĭ genetiki im. N.I. Vavilova RAN

Korsunskaia I.M.

Centre of Theoretical Problems of Physico-Chemical Pharmacology, Russian Academy of Sciences

Bruskin S.A.

N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow

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