Relative significance of apoptotic and proliferative processes, neoangiogenesis, and cellular differentiation for immune inflammation at sites affected by circumscribed alopecia

Gadzhigoroeva A.G.; Kogan E.A.; Potekaev N.N.; Tereshchenko G.P.; Demura T.A.

doi:https://doi.org/

Gadzhigoroeva A.G.

I.M. Sechenov Moscow Medical Academy

Kogan E.A.

Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova, Moskva

Potekaev N.N.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology, Moscow, Russia

SPIN RSCI: 8862-5688
Scopus AuthorID: 56437430600
ORCID: 0000-0002-9578-5490

Tereshchenko G.P.

I.M. Sechenov Moscow Medical Academy

Demura T.A.

Kafedra patologicheskoĭ anatomii im. I.M. Strukova Pervogo Moskovskogo gosudarstvennogo meditsinskogo universiteta im. I.M. Sechenova

Relative significance of apoptotic and proliferative processes, neoangiogenesis, and cellular differentiation for immune inflammation at sites affected by circumscribed alopecia

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Gadzhigoroeva A.G., Kogan E.A., Potekaev N.N., Tereshchenko G.P., Demura T.A.

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Journal: Russian Journal of Clinical Dermatology and Venereology. 2010;8(2): 25‑34

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Gadzhigoroeva AG, Kogan EA, Potekaev NN, Tereshchenko GP, Demura TA. Relative significance of apoptotic and proliferative processes, neoangiogenesis, and cellular differentiation for immune inflammation at sites affected by circumscribed alopecia. Russian Journal of Clinical Dermatology and Venereology. 2010;8(2):25‑34. (In Russ.)

Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)

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Abstract:

The material studied in the present work included 44 skin samples taken from the scalp region of the patients presenting with circumscribed alopecia (alopecia areata). The study was focused on the elucidation of the relationship between apoptotic and proliferative processes, neoangiogenesis, and cellular differentiation at the affected sites. It was shown that the lesioned skin, unlike the healthy one, was lacking in (CD25/IL-2R-alpha)-positive cells. Cell death in hair follicles is supposed to be mediated through the Fas/FasL apoptotic mechanism and accompanied by the disappearance of unipotent CK15+ stem cells. However, in the papillary layer of hair follicles retained bcl-2-positive cells. These findings may suggest the existence of a genetic mechanism ensuring the possibility of hair regeneration after long-term persistent circumscribed alopecia.

Keywords:

circumscribed alopecia

apoptosis

proliferation

neoangiogenesis

cellular differentiation

homeostasis of perifollicular tissues

Authors:

Gadzhigoroeva A.G.

I.M. Sechenov Moscow Medical Academy

Kogan E.A.

Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova, Moskva

Potekaev N.N.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology, Moscow, Russia

SPIN RSCI: 8862-5688
Scopus AuthorID: 56437430600
ORCID: 0000-0002-9578-5490

Tereshchenko G.P.

I.M. Sechenov Moscow Medical Academy

Demura T.A.

Kafedra patologicheskoĭ anatomii im. I.M. Strukova Pervogo Moskovskogo gosudarstvennogo meditsinskogo universiteta im. I.M. Sechenova

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References:

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