Analysis of indocyanine green plasma disappearance rate in clinical practice

Osovskikh V.V.; Kiseleva L.N.; Kolokolnikov I.N.; Vasilieva M.S.; Bautin A.E.

doi:https://doi.org/10.17116/hirurgia20240225

Osovskikh V.V.

FSBI «Almazov National Medical Research Centre» of the Ministry of Healthcare of the Russian Federation

SPIN RSCI: 7385-5940
Scopus AuthorID: 7801671940
ResearcherID: O-3344-2015
ORCID: 0000-0001-6121-4932

Kiseleva L.N.

Granov Russian Research Center for Radiology and Surgical Technologies

ORCID: 0000-0003-2728-5109

Kolokolnikov I.N.

Peter the Great St. Petersburg Polytechnic University

ORCID: 0000-0002-6183-5728

Vasilieva M.S.

Almazov National Medical Research Center

ORCID: 0000-0003-4973-2109

Bautin A.E.

Almazov National Medical Research Center

SPIN RSCI: 9415-7300
Scopus AuthorID: 6601992723
ORCID: 0000-0001-5031-7637

Analysis of indocyanine green plasma disappearance rate in clinical practice

Authors:

Osovskikh V.V., Kiseleva L.N., Kolokolnikov I.N., Vasilieva M.S., Bautin A.E.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2024;(2‑2): 5‑12

DOI: 10.17116/hirurgia20240225

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To cite this article:

Osovskikh VV, Kiseleva LN, Kolokolnikov IN, Vasilieva MS, Bautin AE. Analysis of indocyanine green plasma disappearance rate in clinical practice. Pirogov Russian Journal of Surgery. 2024;(2‑2):5‑12. (In Russ.)
https://doi.org/10.17116/hirurgia20240225

Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)

Использование инфографики авторами научных работ

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OBJECTIVE

To justify the optimal method for determining indocyanine green plasma disappearance rate (PDR_ICG).

MATERIAL AND METHODS

We analyzed PDR_ICG in intensive care units. Indocyanine green was administered intravenously at a dose of 0.25 mg/kg. PDR_ICG was analyzed simultaneously by using of three methods: 1) PDD (PiCCO2 LiMON device), 2) SBS with analysis of plasma samples on precise spectrophotometer, 3) SBS with analysis of plasma samples on simple experimental photometer.

RESULTS

PDD method was used for 346 PDR_ICG tests in 256 patients. Of these, 14.3% of measurements were erroneous. Paired tests using PDD and SBS methods were performed in 299 cases. SBS method resulted erroneous data in 0.6% of cases. Certain correlation (r=0.79, p<0.001) was found between the reference method (SBS with spectrophotometry) and the PDD method. Bland—Altman plot for these two methods showed that proportional bias of mean difference was caused by extremely high PDR_ICG of the PDD method (for example, more than 30%/min). Comparison of two SBS variants (spectrophotometer and experimental photometer) revealed good correlation (r=0.91, p<0.001).

CONCLUSION

SBS method for measuring PDR_ICG ensures accurate results under mechanical interferences in patients with impaired capillary blood flow. This eliminates the need for redo measurement. Duplication of the PDD and SBS methods is recommended when repeating the test is not possible (organ donors).

Keywords:

indocyanine green

liver function test

sequential blood sampling

pulse dye densitometry

Authors:

Osovskikh V.V.

FSBI «Almazov National Medical Research Centre» of the Ministry of Healthcare of the Russian Federation

SPIN RSCI: 7385-5940
Scopus AuthorID: 7801671940
ResearcherID: O-3344-2015
ORCID: 0000-0001-6121-4932

Kiseleva L.N.

Granov Russian Research Center for Radiology and Surgical Technologies

ORCID: 0000-0003-2728-5109

Kolokolnikov I.N.

Peter the Great St. Petersburg Polytechnic University

ORCID: 0000-0002-6183-5728

Vasilieva M.S.

Almazov National Medical Research Center

ORCID: 0000-0003-4973-2109

Bautin A.E.

Almazov National Medical Research Center

SPIN RSCI: 9415-7300
Scopus AuthorID: 6601992723
ORCID: 0000-0001-5031-7637

Received:

10.10.2023

Accepted:

01.12.2023

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References:

Kaprin AD, Ivanov SA, Petrov LO, Isaeva AG. Indocyanine green in liver tumor resection. Khirurgiya. Zurnal im. N.I. Pirogova. 2023;(9-2):5-10. (In Russ.). https://doi.org/10.17116/hirurgia20230925
Horisberger K, Rössler F, Oberkofler CE, Raptis D, Petrowsky H, Clavien PA. The value of intraoperative dynamic liver function test ICG in predicting postoperative complications in patients undergoing staged hepatectomy: a pilot study. Langenbeck’s Archives of Surgery. 2023;408(1):264. https://doi.org/10.1007/s00423-023-02983-5
Schwarz C, Plass I, Fitschek F, Punzengruber A, Mittlböck M, Kampf S, Asenbaum U, Starlinger P, Stremitzer S, Bodingbauer M, Kaczirek K. The value of indocyanine green clearance assessment to predict postoperative liver dysfunction in patients undergoing liver resection. Scientific Reports. 2019;9(1):8421. https://doi.org/10.1038/s41598-019-44815-x
Novruzbekov MS, Lutsyk KN, Olisov OD, Magomedov KM, Kazymov BI, Alekberov KF, Akhmedov AR, Yaremin BI. Indocyanine green in liver transplantation. Khirurgiya. Zurnal im. N.I. Pirogova. 2023;(9-2):63-72. (In Russ.). https://doi.org/10.17116/hirurgia202309263
Horvatits T, Kneidinger N, Drolz A, Roedl K, Rutter K, Kluge S, Trauner M, Fuhrmann V. Prognostic impact of ICG-PDR in patients with hypoxic hepatitis. Annals of Intensive Care. 2015;5(1):47. https://doi.org/10.1186/s13613-015-0092-6
Quintero J, Miserachs M, Ortega J, Bueno J, Dopazo C, Bilbao I, Castells L, Charco R. Indocyanine green plasma disappearance rate: a new tool for the classification of paediatric patients with acute liver failure. Liver International. 2013;34(5):689-694. https://doi.org/10.1111/liv.12298
Luerken L, Dollinger M, Goetz A, Utpatel K, Doppler MC, Weiss JB, Uller W, Ignee A, Verloh N, Haimerl M. Diagnostic Accuracy of Indocyanine Green Clearance Test for Different Stages of Liver Fibrosis and Cirrhosis. Diagnostics. 2023;13(16):2663. https://doi.org/10.3390/diagnostics13162663
Zarrinpar A, Lee C, Noguchi E, Yersiz H, Agopian VG, Kaldas FM, Farmer DG, Busuttil RW. A rapid, reproducible, noninvasive predictor of liver graft survival. Journal of Surgical Research. 2015;197(1):183-190. https://doi.org/10.1016/j.jss.2015.03.093
Vos JJ, Wietasch JK, Absalom AR, Hendriks HG, Scheeren TW. Green light for liver function monitoring using indocyanine green? An overview of current clinical applications. Anaesthesia. 2014;69(12):1364-1376. https://doi.org/10.1111/anae.12755
Purcell R, Kruger P, Jones M. Indocyanine green elimination: a comparison of the LiMON and serial blood sampling methods. ANZ Journal of Surgery. 2006;76(1-2):75-77. https://doi.org/10.1111/j.1445-2197.2006.03643.x
Sakka SG, Reinhart K, Meier-Hellmann A. Comparison of invasive and noninvasive measurements of indocyanine green plasma disappearance rate in critically ill patients with mechanical ventilation and stable hemodynamics. Intensive Care Medicine. 2000;26(10):1553-1556. https://doi.org/10.1007/s001340000639
Savchenko E, Kolokolnikov I, Velichko E, Osovskikh V, Kiseleva L, Musakulova Z. Design of Liver Functional Reserve Estimation Technique Based on Optical Densitometry. Diagnostics. 2020;10(8):599. https://doi.org/10.3390/diagnostics10080599
Critchley LA, Critchley JA. A meta-analysis of studies using bias and precision statistics to compare cardiac output measurement techniques. Journal of clinical monitoring and computing. 1999;15(2):85-91. https://doi.org/10.1023/a:1009982611386
Bland JM, Altman DG. Measuring agreement in method comparison studies. Statistical Methods in Medical Research. 1999;8(2):135-160. https://doi.org/10.1177/096228029900800204