Living related liver transplantation in the Republic of Uzbekistan: current status and development prospects

Porkhanov VA, Ismailov SI, Nazyrov FG, et al. Living related liver transplantation in the Republic of Uzbekistan: current status and development prospects. Pirogov Russian Journal of Surgery. 2023;(11):34‑46. (In Russ.)
https://doi.org/10.17116/hirurgia202311134

Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)

Использование инфографики авторами научных работ

Close metadata

OBJECTIVE

To analyze primary results of living related liver transplantation in the Republic of Uzbekistan.

MATERIAL AND METHODS

There were 44 living related transplantations of the right liver lobe in patients with decompensated liver failure between February 2018 and February 2023.

RESULTS

Uneventful postoperative period was observed in 17 (38.6%) recipients. Other 27 patients (61.4%) developed 47 various postoperative complications (1—3 events per a patient). Of these, 8 (18.2%) patients required early postoperative re-laparotomy. Among 44 patients, 9 (20.5%) ones died in early postoperative period, and one patient died in long-term period (3 years after transplantation) from chronic rejection under refusal to take immunosuppressive drugs. Early satisfactory results were obtained in 79.5% of patients, long-term favorable outcomes — in 77.3% of cases.

CONCLUSION

Engraftment rates and survival of recipients to a large extent depend on surgical strategy, baseline disease and clinical severity. The so-called “center effect” is essential at initial stages of implementation of the program.

Keywords:

liver transplantation

end-stage liver disease

complication rate

living related donors

Authors:

Porkhanov V.A.

Research Institute — Ochapovsky Regional Clinical Hospital No.1

SPIN RSCI: 2446-5933
ORCID: 0000-0003-0572-1395

Ismailov S.I.

Vakhidov Republican Specialized Scientific Practical Medical Center of Surgery

ORCID: 0000-0002-4646-3938

Nazyrov F.G.

Vakhidov Republican Specialized Scientific Practical Medical Center of Surgery

ORCID: 0000-0003-2891-8748

Popov A.Yu.

Research Institute — Ochapovsky Regional Clinical Hospital No.1

SPIN RSCI: 1244-5034
ORCID: 0000-0003-1336-7242

Babadzhanov A.Kh.

Vakhidov Republican Specialized Scientific Practical Medical Center of Surgery

ORCID: 0000-0002-4403-1859

Lishchenko A.N.

Research Institute — Ochapovsky Regional Clinical Hospital No.1

ORCID: 0000-0002-8355-787X

Ibadov R.A.

Vakhidov Republican Specialized Scientific Practical Medical Center of Surgery

ORCID: 0000-0002-0992-0802

Baibekov R.R.

Vakhidov Republican Specialized Scientific Practical Medical Center of Surgery

ORCID: 0000-0001-8032-0888

Received:

13.05.2023

Accepted:

10.06.2023

Close metadata

References:

Goldaracena N, Barbas AS. Living donor liver transplantation. Current Opinion in Organ Transplantation. 2019;24(2):131-137. https://doi.org/10.1097/MOT.0000000000000610
Sakai T, Ko JS, Crouch CE, Kumar S, Choi GS, Hackl F, Han DH, Kaufman M, Kim SH, Luzzi C, McCluskey S, Shin WJ, Sirianni J, Song KW, Sullivan C, Hendrickse A. Perioperative management of living donor liver transplantation: Part 2 — Donors. Clinical Transplantation. 2022;36(6):e14690. https://doi.org/10.1111/ctr.14690
Babadzhanov AKh. Kontseptual’nyye osnovy portosistemnogo shuntirovaniya s integral’noy otsenkoy prognoza zhizni u bol’nykh tsirrozom pecheni: Dis. ... d-ra med. nauk. Tashkent. 2014. (In Russ.).
Nazyrov FG, Devyatov AV, Akbarov MM, Ibadov RA, Juraeva NM, Babajanov AKh, Salimov UR, Nishanov MSh. Liver transplantation from a living related donor (literature review). Surgery in Uzbekistan. 2018;4:53-59. (In Russ.).
Porshennikov IA, Pavlik VN, Shchekina EE, Kartashov AS, Korobeynikova MA, Yushina EG, Bykov AYu. Liver transplantation in the Novosibirsk region: development of the program and its results. Almanac of Clinical Medicine. 2018;46(6):560-571. (In Russ.).
Meirelles Júnior RF, Salvalaggio P, Rezende MB, Evangelista AS, Guardia BD, Matielo CE, Neves DB, Pandullo FL, Felga GE, Alves JA, Curvelo LA, Diaz LG, Rusi MB, Viveiros Mde M, Almeida MD, Pedroso PT, Rocco RA, Meira Filho SP. Liver transplantation: history, outcomes and perspectives. Einstein (Sao Paulo). 2015;13(1):149-52. https://doi.org/10.1590/S1679-45082015RW3164
Lerut J. Living donor liver transplantation: A complex but worthwhile undertaking. Hepatobiliary & Pancreatic Diseases International. 2020;19(4):305-306. https://doi.org/10.1016/j.hbpd.2020.06.018
Fisher RA. Living donor liver transplantation: eliminating the wait for death in end-stage liver disease? Nature Reviews Gastroenterology & Hepatology. 2017;14(6):373-382. https://doi.org/10.1038/nrgastro.2017.2
Samuel D, Coilly A. Management of patients with liver diseases on the waiting list for transplantation: a major impact to the success of liver transplantation. BMC Medicine. 2018;16(1):113. https://doi.org/10.1186/s12916-018-1110-y
Gong N, Chen X. Partial liver transplantation. Frontiers in Medicine. 2011;5(1):1-7. https://doi.org/10.1007/s11684-010-0105-7
Novruzbekov MS. Transplantatsiya pecheni (operativnaya tekhnika, diagnostika, lecheniye i profilaktika posleoperatsionnykh oslozhneniy): Dis. ... d-ra med. nauk. M. 2018. (In Russ.).