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Skripko V.D.

GVUZ "Ivano-Frankovskiĭ natsional'nyĭ meditsinskiĭ universitet"

Kovalenko A.L.

Direktsiia po nauke OOO "NTFF "Polisan", Sankt-Peterburg

Zaplutanov V.A.

I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Saint Petersburg, Russia

Microelemental homeostasis correction of and oxidative stress in patients with acute intestinal obstruction

Authors:

Skripko V.D., Kovalenko A.L., Zaplutanov V.A.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2017;(6): 55‑59

DOI: 10.17116/hirurgia2017655-59

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To cite this article:

Skripko VD, Kovalenko AL, Zaplutanov VA. Microelemental homeostasis correction of and oxidative stress in patients with acute intestinal obstruction. Pirogov Russian Journal of Surgery. 2017;(6):55‑59. (In Russ.)
https://doi.org/10.17116/hirurgia2017655-59

Подписка 2025 (Pirogov Russian Journal of Surgery)
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Aim. To improve the results of treatment of patients with acute small bowel obstruction. Matherials and methods. The research is based on the results of a comprehensive survey 202 people with acute small bowel obstruction. Reamberin was used in 102 patients treatment. Results. It was established that metalloenzymes take an active part in the formation of endotoxemia in people with acute small bowel obstruction. Also, in patients as a result of an imbalance between oxidant and antioxidant systems, accumulated a significant amount of lipid peroxidation products, along with it a decrease activity of enzymes of antioxidant system. reamberin application in complex treatment of acute small bowel obstruction provided the reduction in the time correction of oxidative stress by preventing the growth and activity of lipid peroxidation products with simultaneous stimulation of the antioxidant system and contributed to the normalization of microelement homeostasis.

Keywords:

acute small bowel obstruction
microelements
lipid peroxidation
antioxidant system

Authors:

Skripko V.D.

GVUZ "Ivano-Frankovskiĭ natsional'nyĭ meditsinskiĭ universitet"

Kovalenko A.L.

Direktsiia po nauke OOO "NTFF "Polisan", Sankt-Peterburg

Zaplutanov V.A.

I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Saint Petersburg, Russia

List of references:

  1. Kradinov AI, Chemodanov EB. Diagnostics questions of acute bowel obstruction. Krymskij zhurnal jeksperim. i klin. mediciny. 2011;1(1):73-78. (In Russ.).
  2. Lazarenko VA, Lipatov VA, Sotnikov AS, Efremenkov AM, Bulatkin AA, Lazarenko SV. Modern semiotics of acute adhesive intestinal obstruction. Krymskij zhurnal jeksperim. i klin. mediciny. 2012;5(2):292-296(In Russ.).
  3. Aliev SA, Sultanov GA, Jefendiev MA. Some aspects of the pathogenesis of hypoxia and non-pharmacological methods of its correction with purulent peritonitis. Vestn. intensiv. terapii. 2003;2:20-27. (In Russ.).
  4. Kosinec VA. Syndrome of enteric insufficiency: pathogenesis and modern principles of diagnosis and treatment. Novosti hirurgii (Vitebsk). 2008;16(2):130-138. (In Russ.).
  5. Bashkіrova G, Rudenko A. The biological role of some of essential macro and micronutrients (Review). Lekarstva Ukrainy. 2004;10:59-65. (In Ukrainian).
  6. Dzjubanovs'kij ІJa, Mіgen'ko BO. Dynamics of activity of antioxidant system in patients with acute peritonitis. Klinicheskaja i jeksperimental'naja patologija. 2007;6(3):38-40. (In Ukrainian).
  7. Klimenko JuA. Pathogenetic significance dysfunction metal-metal-protein systems in the development of endogenous intoxication in patients with peritonitis. Gospital'naja hirurgija. 2007;3:30-33. (In Ukrainian).
  8. Kosinec VA. The functional state of mitochondria in muscle layer of the small intestine at experimental widespread purulent peritonitis. Vestnik VGMU. 2007;4:31-38. (In Russ.).
  9. Kudrin AV, Skal'nyj AV, Zhavoronkov AA. Immunofarmakologija mikrojelementov. Moscow: KMK Publishing; 2000. (In Russ.).
  10. Perehodov SN, Miljukov VE, Telepanov DN. Some aspects of pathogenesis of the multiple organ failure by acute bowel obstruction. Hirurgija. 2010;12:70-72. (In Russ.).
  11. Obolenskij SV. Reamberin — novoe sredstvo dlja infuzionnoj terapii v praktike mediciny kriticheskih sostojanij. Metod. rekom. SPb. 2002. (In Russ.).

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