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Dukhanin A.S.

Pirogov Russian National Research Medical University, Department of Molecular Pharmacology and Radiobiology, Moscow, Russia

What determines the effectiveness and safety of topical treatment of hemorrhoids

Authors:

Dukhanin A.S.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2017;(10): 113‑119

DOI: 10.17116/hirurgia201710113-119

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To cite this article:

Dukhanin AS. What determines the effectiveness and safety of topical treatment of hemorrhoids. Pirogov Russian Journal of Surgery. 2017;(10):113‑119. (In Russ.)
https://doi.org/10.17116/hirurgia201710113-119

Подписка 2025 (Pirogov Russian Journal of Surgery)
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Keywords:

glucocorticosteroids
local anesthetics
heparin
combined topical therapy

Authors:

Dukhanin A.S.

Pirogov Russian National Research Medical University, Department of Molecular Pharmacology and Radiobiology, Moscow, Russia

List of references:

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  2. Löwenberg M, Stahn C, Hommes DW, Buttgereit F. Novel insights into mechanisms of glucocorticoid action and the development of new glucocorticoid receptor ligands. Steroids. 2008;73(9-10):1025-1029. https://doi.org/10.1016/j.steroids.2007.12.002
  3. Bell DS. Combine and conquer: advantages and disadvantages of fixed-dose combination therapy. Diabetes Obes Metab. 2013;15(4):291-300. https://doi.org/10.1111/dom.12015
  4. Barnes PJ. How corticosteroids control inflammation: Quintiles Prize Lecture 2005. Br J Pharmacol. 2006;148(3):245-254. https://doi.org/10.1038/sj.bjp.0706736
  5. Rosen J, Miner JN. The search for safer glucocorticoid receptor ligands. Endocr Rev. 2005;26(3):452-464. https://doi.org/10.1210/er.2005-0002
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  7. Brunton LL, Chabner BA, eds. Goodman and Gilman’s the pharmacological basis of therapeutics. 12th ed. New York: McGraw-Hill; 2011.
  8. Stahn C, Buttgereit F. Genomic and nongenomic effects of glucocorticoids. Nat Clin Pract Rheumatol. 2008;4(10):525-533. https://doi.org/10.1038/ncprheum0898
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  11. Buchwald P. Glucocorticoid receptor binding: a biphasic dependence on molecular size as revealed by the bilinear LinBiExp model. Steroids. 2008;73(2):193-208. https://doi.org/10.1016/j.steroids.2007.10.001
  12. Agnes E, Coutinho AE, Chapman KE. The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights. Mol Cell Endocrinol. 2011;335(1):2-13. https://doi.org/10.1016/j.mce.2010.04.005
  13. Helfer EL, Rose LI. Adrenal Cortical Steroids. In: Drug Facts and Comparisons. 5th ed. St. Louis: Drug Facts and Comparisons, Inc.; 1997;122-128.
  14. Bikowski J, Pillai R, Shroot B. The position not the presence of the halogen in corticosteroids influences potency and side effects. J Drugs Dermatol. 2006;5(2):125-130. Accessed Jule 17, 2017. http://findarticles.com/p/articles/mi_m0PDG/is_2_5/ai_n16085948
  15. European Medicines Agency. Accessed Jule 17, 2017. http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/referrals/Bufexamac/human_referral_000209.jsp&mid=WC0b01ac05805c516f
  16. Thornton SC. Hemorrhoids Treatment & Management. Updated: Jan 18, 2017. Accessed Jule 17, 2017. http://emedicine.medscape.com/article/775407-treatment
  17. Ng L, Monagle K, Monagle P, Newall F, Ignjatovic V. Topical use of antithrombotics: review of literature. Thromb Res. 2015;135(4):575-581. https://doi.org/10.1016/j.thromres.2015.01.006
  18. Gupta PJ. Use of enzyme and heparin paste in acute haemorrhoids. Rom J Gastroenterol. 2002;11(3):191-195. Accessed Jule 17, 2017. https://www.ncbi.nlm.nih.gov/pubmed/12368938
  19. Musalatov KhA, Silin LL, Brovkin SV. Clinical efficacy of Lyoton-1000 and Fastum-gel application in soft tissue injuries of limbs. Klinicheskie issledovaniya lekarstvennykh sredstv v Rossii. 2015;15:872. (In Russ.)
  20. Kandrotas RJ. Heparin pharmacokinetics and pharmacodynamics. Clin Pharmacokinet. 1992;22(5):359-374. https://doi.org/10.2165/00003088-199222050-00003
  21. Lauromacrogol 400. http://www.rlsnet.ru/mnn_index_id_1748.htm
  22. Daniel E, Becker DE, Kenneth L, Reed KL. Local Anesthetics: Review of Pharmacological Considerations. Anesth Prog. 2012;59(2):90-102. https://doi.org/10.2344/0003-3006-59.2.90
  23. Covino BG. Pharmacology of local anaesthetic agents. Br J Anaesth. 1986;58(7):701-716. Accessed Jule 17, 2017. https://www.ncbi.nlm.nih.gov/pubmed/2425835
  24. Dollery C (Ed): Therapeutic Drugs — Volume 2. Second edition — Lidocaine (hydrochloride). Churchill Livingstone Edinburgh — London — New York — Philadelphia — San Francisco — Sydney — Toronto: L52-L56, 1999.
  25. Relief® Pro. http://www.rlsnet.ru/tn_index_id_66965.htm
  26. Blagodarnyi LA. The choice of drug therapy for hemorrhoids. Khirurgiya. Prilozhenie k zhurnalu Consilium Medicum. 2013;2. (In Russ.)

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