The combination of chondroitin sulfate and glucosamine (artra) for pain relief and to reduce the consumption of NSAIDs in patients with I-II stages of osteoarthritis of the knee

The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Search result: 0

Rodionova S.S.

Central Research Institute of Traumatology and Orthopedics n.a. N.N. Priorov, Moscow, Russia

Es'kin N.A.

Central Institute of Traumatology and Orthopaedies named after N.N. Priorov, Moscow

The combination of chondroitin sulfate and glucosamine (artra) for pain relief and to reduce the consumption of NSAIDs in patients with I-II stages of osteoarthritis of the knee

Authors:

Rodionova S.S., Es'kin N.A.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2016;(1): 67‑72

DOI: 10.17116/hirurgia2016167-72

Views: 2624

Downloaded: 36

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Rodionova SS, Es'kin NA. The combination of chondroitin sulfate and glucosamine (artra) for pain relief and to reduce the consumption of NSAIDs in patients with I-II stages of osteoarthritis of the knee. Pirogov Russian Journal of Surgery. 2016;(1):67‑72. (In Russ.)
https://doi.org/10.17116/hirurgia2016167-72

Подписка 2025 (Pirogov Russian Journal of Surgery)

Close metadata

Recommended articles:

Disease-modifying therapy and adjuvant support in complex therapy of chronic non-specific low back pain. Resolution of the Multidisciplinary Board of Experts. Russian Journal of Pain. 2024;(3):108-116

The analysis of the dynamics of pain and joint function on the background of the 3-month ARTRA.Study was conducted as a multicenter, with the inclusion of 3077 patients, 56.2% of whom received NSAIDs for pain relief. While taking after a month of therapy showed significant compared to the original value of reducing the intensity of pain. The therapeutic effect is increased with duration of dosing. It is shown that the drug reduces the need for arthritis NSAIDs after a month by 6.8%, after 3 months - by 37.3%, ie after the 3-month course of treatment with arthritis, the number of people taking NSAIDs fell by more than 3 times (up 18.9%). A significant reduction in consumption, coupled with the marked dynamics of the pain is regarded by us as a manifestation expressed anesthetic effect of the drug ARTRA.

Keywords:

knee osteoarthritis

glucosamine sulfate

chondroitin sulfate

symptomatic therapy

tolerability

Authors:

Rodionova S.S.

Central Research Institute of Traumatology and Orthopedics n.a. N.N. Priorov, Moscow, Russia

Es'kin N.A.

Central Institute of Traumatology and Orthopaedies named after N.N. Priorov, Moscow

List of references:

Alekseeva L.I., Chichasova N.V., Mendel' O.I., Artemenko N.A., Zotkin E.G., Lesnyak O.M., Kudryavtseva N.V., Men'shikova L.V. Ratsional'nyi vybor bazisnoi terapii pri osteoartroze. Rezul'taty otkrytogo randomizirovannogo mnogotsentrovogo issledovaniya preparata ARTRA v Rossii. Rezhim dostupa: http://rmj.ru/articles_4070.htm1637.
Kashevarova I.G., Zaitseva E.M., Pushkova O.V., Smirnov A.V., Alekseeva L.I. Faktory progressirovaniya osteoartroza kolennykh sustavov (5-letnee prospektivnoe nablyudenie). Osteoporoz i osteopatii. 2013;(2): 9-11.
Naumov A.V., Vertkin A.L., Mendel' O.I., Alliluev A.A., Filimonov V.S. Kak povysit' bezopasnost' i effektivnost' "antiartroznoi" terapii u patsientov s somaticheskoi patologiei. Russkii meditsinskii zhurnal. 2007;15(26):1-8.
Rodionova S.S., Es'kin N.A., Matveeva N.Yu., Morozova N.S. Ratsional'nyi vybor lecheniya nachal'nykh stadii gonartroza u patsientov, stradayushchikh sistemnym osteoporozom. Vestnik travmatologii i ortopedii im. N.N. Priorova. 2014;2:52-56.
Chichasova N.V., Imametdinova G.R., Igolkina E.V., Nasonov E.L. Khronicheskie zabolevaniya sustavov. Lechashchii vrach. 2013;5:84.
Anand B, Kharat A, Singh A, Franklin J, Naware S, Singh S. High resolution ultrasound evaluation of synovial thickness as a marker to assess response to deep tissue heating for pain relief in knee osteoarthritis. Med J DY Patil Univ. 2012;5(2):129-136.
Bijlsma JW, Berenbaum F, Lafeber FP. Osteoarthritis: an update with relevance for clinical practice. Lancet. 2011;377(9783):2115-2126.
Cutolo M, Berenbaum F, Hochberg M, Punci L, Reginster JY. Commentary on recent therapeutic guidelines for osteoarthritis. Semin Arthritis Rheum. 2015;44(6):611-617.
Das A, Hendsonville J, Eitel J, Hammad T. Efficacy of a new class of agents (Glucosamine Hydrochloride and Chondroitin Sulfate) in the treatment of osteoarthritis of the knee. 66th Ann Meeting of American Association of Hip and Knee Surgeons, Dallas, November 6-8; 1998;180.
Mazzeca SA, Brandt KD, Schauwecker DS, Katz BR, Meyer JM, Lane KA, Bradley JD, Hugenberg ST, Wolfe F, Moreland LW, Heck LW, Yocum DE, Schnitzer TJ, Sharma L, Manzi S, Oddis CV. Severity of joint pain and Kellgren-Lawrence grade at baseline are better predictors of joint spacenarrowing than bone scintigraphy in obese women with knee osteoarthritis. J Rheumatol. 2005;32(8):1540-1546.
Michel B, Bruhlmann P, Stucki G, Uebelhart D. Chondroprotection through Chondrosulf: the Zurich study. Ann Rheum Dis. 2002;61(suppl 1):116.
Pincus T, Sokka T. Abstract presented during the American College of Rheumatology 2005 Scientific Sessions, San Diego, California.
Register J-Y, Rovati L, Deroisy R. Glucosamine sulfate slows-down osteoarthritis progression in postmenopausal women: pooled analysis of two large, independent, randomized, placebo-controlled, double-blind, prospective 3 year trials. Ann Rheum Dis. 2002;61(suppl 1):THU0196.
Tangtrakulwanich B, Suwanno P. Epidemiology and risk factors of patellofemoral osteoarthritis in adults: a population-based study in southern Thailand. J Med Assoc Thai. 2012;95(8):1048-1052.
Underwood M, Ashby D, Carnes D, Castelnuovo E, Cross P, Harding G, Hennessy E, Letley L, Martin J, Mt-Isa S, Parsons S, Spencer A, Vickers M, Whyte K. Topical or oral ibuprofen for chronic knee pain in older people. The TOIB study. Health Technol Assess.2008;12:I-IV, 9-15.
Verbruggen G, Goemaere S, Veys E. Systems to assess the progression of finger joint osteoarthritis and effects of disease modifying osteoarthritis drugs. Clin Rheum. 2002;21:231-243.

Close metadata

Log in to the site using your account in one of the services

Registration

Last Name

Name

Middle Name

E-mail

Phone

Address

Country

Zip

City

Region

Street

Home

Apartmen

Legal entity name

ИНН

КПП

Password

Password

Repeat password

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.