True cystic tumors of the pancreas

Close metadata

Recommended articles:

Pancreatic mucinous cystadenoma with atypical clinical presentation. Pirogov Russian Journal of Surgery. 2023;(12):118-122

Direct transfistulous ultrasound in minimally invasive surgical treatment of infected pancreatic necrosis. Pirogov Russian Journal of Surgery. 2024;(4):38-43

Synchronous primary multiple cancer: distal cholangiocarcinoma of the intrapancreatic common bile duct and intraductal papillary mucinous tumor associated with ductal adenocarcinoma of the pancreatic tail. Pirogov Russian Journal of Surgery. 2024;(8):57-63

Robotic enucleation of pancreatic insulinoma. Pirogov Russian Journal of Surgery. 2024;(8):64-68

Endoscopic ultrasonography and endoscopic ultrasonography with fine needle aspiration in the diagnosis of neuroendocrine neoplasms of the pancreas. Endoscopic Surgery. 2023;(6):19-27

Methods of pancreatic fibrosis assessment. Russian Journal of Evidence-Based Gastroenterology. 2024;(1):48-57

Minimally invasive surgical treatment of acute necrotic collections without a progressive exudative component in patients with purulent-necrotic parapancreatitis. Endoscopic Surgery. 2024;(2):12-18

Solid pseudopapillary tumor of the pancreas. P.A. Herzen Journal of Oncology. 2024;(5):50-53

Retrospective analysis of treatment results was carried out in 37 patients that had been treated during 1984-2009 years. Mean age of the patients was 50.7 years; among them 94.6% were women. 8 (21.6%) patients had serous cystadenoma, 21 (56.8%) patients - mucinous cystadenoma, 7 (18,9%) patients - cystadenocarcinoma and 1 (2.7%) patient - intraductal papillary-mucinous tumor. Distal pancreatic resection was carried out to 19 patients, pancreatoduodenal resection - in 5 patients, enucleation - in 10 patients, midline resection - in 1 patient, pancreatectomy - in 2 patients. The frequency of complications amounted 35.1%; lethal outcomes were not observed. Pancreatitis (in 7 patients) and pancreatic fistula (in 4 patients) were the most common complications. Re-laparotomy was necessary for destructive pancreatitis in 2 observations. Other complications were treated conservatively. Long-term results were studied in 28 (76%) patients. Mean duration of the observation was 87,3 months (6-120 months). 5-year survival rate amounted 100% among patients with benign cystic tumors of the pancreas and 25% in patients with cystadenocarcinoma. It is drawn a conclusion that complete recovery is quite possible in patients with benign tumors whereas treatment of the patients with invasive cystadenocarcinoma demonstrate poor results in long-term period.

Keywords:

pancreas

cystic neoplasms

cystic tumors

Authors:

Skipenko O.G.

Rossiĭskiĭ nauchnyĭ tsentr khirurgii im. B.V. Petrovskogo RAMN, Moskva

Ponomar' S.A.

Otdelenie khirurgii pecheni, zhelchnykh puteĭ i podzheludochnoĭ zhelezy Rossiĭskogo nauchnogo tsentra khirurgii im. akad. B.V. Petrovskogo RAMN, Moskva

Bedzhanyan A.L.

Petrovsky Russian Research Center for Surgery, Moscow, Russia

ORCID: 0000-0002-4377-0035

Sekacheva M.I.

Otdelenie khirurgii pecheni, zhelchnykh puteĭ i podzheludochnoĭ zhelezy Rossiĭskogo nauchnogo tsentra khirurgii im. akad. B.V. Petrovskogo RAMN, Moskva

Abdullaev A.G.

Otdelenie khirurgii pecheni, zhelchnykh puteĭ i podzheludochnoĭ zhelezy Rossiĭskogo nauchnogo tsentra khirurgii im. akad. B.V. Petrovskogo RAMN, Moskva

List of references:

Adsay N.V. Cystic lesions of the pancreas. Modern Pathology 2007; 20: 71-93.
Adsay N.V., Conlon K., Zee S.Y. et al. Intraductal papillary-mucinous neoplasms of the pancreas: an analysis of in situ and invasive carcinomas in 28 patients. Cancer 2002; 94: 62-77.
Allen P.J., Jaques D.P., D'Angelica M. et al. Cystic lesions of the pancreas: selection criteria for operative and nonoperative management in 209 patients. J Gastrointest Surg 2003; 7: 970-977.
Bassi C., Salvia R., Gumbs A.A. et al. The value of standart serum tumor markers in differentiating mucinous from serous cystic tumors of the pancreas: CEA, Ca 19-9, Ca 125, Ca 15-3. Langenbecks Arch Surg 2002; 387: 281-285.
Bassi C., Salvia R., Molinari E. et al. Management of 100 consecutive cases of pancreatic serous cystadenoma: wait for symptoms and see at imaging or vice versa? World J Surg 2003; 27: 319-323.
Brian K.P. Goh, Yu-Meng Tan et al. Pancreatic cysts: a proposed management algorithm based on current evidence. American J Surgery 2007; 193: 749-755.
Carboni F., Lepiane P., Santoro R. et al. Cystic pancreatic neoplasms: 12-year surgical experience. J Exp Clin Cancer Res 2006; 25: 167-174.
Dennis Z.W., Goh B.K.P. et al. Cystic neoplasms of the pancreas: Current diagnostic modalities and management. Ann Acad Med Singapore 2009; 38: 251-259.
Doi R., Fujimoto K., Wada M. et al. Surgical management of intraductal papillary mucinous tumor of the pancreas. Surgery 2002; 132: 80-85.
Domingues L.A., Chedid M.F. et al. Radical surgical treatment for neoplasms of the pancreas: Personal experience. Rev Gastroenterol Peru 2005; 25: 42-47.
Falconi M., Bassi C., Dervenis C. et al. Cystic tumours of the pancreas: a review. Chir Ital 2001; 53: 595-608.
Farnell M.B. Surgical management of intraductal papillary mucinous neoplasms of the pancreas. J Gastrointest Surg 2008; 12: 414-416.
Fernandez-del Castillo C., Targarona J., Thayer S.P. et al. Incidental pancreatic cysts: clinicopathologic characteristics and comparison with symptomatic patients. Arch Surg 2003; 138: 427-433 (discussion 433-434).
Fernandez-del C.C. Mucinous cystic neoplasms. J Gastrointest Surg 2008; 12: 411-413.
Fritz S., Warshaw A.L., Thayer S.P. Management of mucin-producing cystic neoplasms of the pancreas. The Oncologist 2009; 14: 125-136.
Garcea G., Ong Sl., Rajesh A. et al. Cystic lesions of the pancreas. A diagnostic and management dilemma. Pancreatology. 2008; 8(3): 236-251. (abstract) Salvia R., Festa L., Butturini G., Tonsi A., Sartori N., Biasutti C. et al. Pancreatic cystic tumors. Minerva Chir 2004; 59: 185-207.
Goh B.K.P., Tan Y.M., Cheow P.C. et al. Cystic neoplasms of the pancreas with mucin-production. Eur J Surg Oncol 2005; 31: 282-287.
Goh B.K., Tan Y.M., Yap W.M. et al. Pancreatic serous oligocystic adenomas: clinicopathologic features and a comparison with serous microcystic adenomas and mucinous cystic neoplasms. World J Surg 2006; 30: 1553-1559.
Goh B.K., Tan Y.M., Chung Y.F. et al. Pancreatic cyst: a proposed management algorithm based on current evidence. Am J Surg 2007; 193: 749-755.
Goh B.K., Tan Y.M., Thng C.H. et al. How useful are clinical, biochemical and cross-sectional imaging features in predicting potentially malignant or malignant cystic lesions of the pancreas? Results from institution experience with 220 surgically treated patients. J Am Coll Surg 2008; 206: 17-27.
Grippa S., Salvia R., Warshaw A.L. et al. Mucinous cystic neoplasms of the pancreas is not an aggressive entity: Lessons from 163 resected patients. Ann Surg 2008; 247: 571-579.
Harper A.E., Eckhauser F.E., Mulholland M.W. Resectional therapy for cystic neoplasm of the pancreas. Am Surg 2002; 68: 353-358.
Hashimoto L., Walsh R.M., Vogt D.P. et al. Presentation and management of cystic neoplasms of the pancreas. J Gastrointest Surg 1998; 2: 504-508.
Hung J.S., Yang C.Y., Hu R.H. et al. Surgical treatment of pancreatic serous cystadenoma: aggressive for operations but limited resections. Pancreas 2007; 35: 4: 358-360.
Jeurnink S.M., Vleggaar F.P., Siersema P.D. Overview of the clinical problem: Facts and current issues of mucinous cystic neoplasms of the pancreas. Degestive and liver disease 2008; 40: 837-846.
Jin-Young Jang, Sun-Whe Kim, Young Joon Ahn et al. Multicenter analysis of clinicopathologic features of intraductal papillary mucinous tumor of the pancreas: is it possible to predict the malignancy before surgery? Ann of Surg Oncol 2005; 12: 124-132.
Kloppel G.S.E., Longnecker D.S., Cappela C. et al. Histogical Typing of Tumours of the Esocrine Pancreas. World Health Organization international Histological Classification of Tumours. Berlin, PA: Springer-Verlag 1996.
Kobari M., Egawa S., Shibuya K. et al. Intraductal papillary mucinous tumors of pancreas comprise 2 clinical subtypes: differences in clinical characteristics and surgical management. Arch Surg 1999; 134: 1131-1136.
Lee C.J., Scheiman J., Anderson M.A. et al. Risk of malignancy in resected cystic tumors of the pancreas 3 cm in size: is it safe to observe asymptomatic patients? A multi-institutional report. J Gastrointest Surg 2008; 12: 2: 234-242 (abstract).
Mulkeen A.L., Yoo P.S., Cha C. Less common neoplasms of the pancreas. World J Gastroenterol 2006; 12: 3180-3185.
Niedergethmann M., Grutzamann R., Hildenbrand R. et al. Outcome of invasive and noninvasive intraductal papillary-mucinous neoplasms of the pancreas (IPMN): a 10-year experience. World J Surg 2008; 32: 2253-2260.
Ooi L.L., Ho G.H., Chew S.P. et al. Cystic tumours of the pancreas: a diagnostic dilemma. Aust NZJ Surg 1998; 68: 844-846.
Pyke C.M., van Heerden J.A., Colby T.V. et al. The spectrum of serous cystadenoma of the pancreas: clinical, pathologic and surgical aspects. Ann Surg 1992; 215: 132-139.
Salvia R., Festa L., Butturini G. et al. Pancreatic cystic tumors. Minerva Chir 2004; 59: 185-207.
Sakorafas G.H., Sarr M.G. Cystic neoplasms of the pancreas; what a clinician should know. Cancer Treat Rev 2005; 31: 507-535.
Sarr M.G., Carpenter H.A., Prabhakar L.P. et al. Clinical and pathologic correlation of 84 mucinous cystic neoplasms of the pancreas: can one reliably differentiate bening from malignant (or premalignant) neoplasms? Ann Surg 2000; 231: 205-212.
Sohn T.A., Yeo C.J., Cameron J.L. et al. Intraductal papillary mucinous neoplasms of the pancreas: an updated experience. Ann Surg 2004; 239: 788-799.
Strobel O., Z'Graggen K., Schmitz-Winnenthal F.H. et al. Risk of malignancy in serous cystic neoplasms of the pancreas. Digestion 2003; 68: 24-33.
Suzuki Y., Atomi Y., Sugiyama M. et al. Cystic neoplasm of the pancreas: a Japanese multiinstitutional study of intraductal papillary mucinous tumour and mucinous cystic tumour. Pancreas 2004; 28: 241-246.
Talamini M.A., Moesinger R., Yeo C.J. et al. Cystadenomas of the pancreas: is enucleation an adequate operation? Ann Surg 1998; 227: 6: 896-903.
Tanaka M., Chari S., Adsay V. et al. International consensus guidelines for management of intraductal papillary neoplasms and mucinous cystic neoplasms of the pancreas. Pancreatology 2006; 6: 17-32.
Thompson L.D.R., Becker R.C., Pryzgodski R.M. et al. Mucinous cystic neoplasm (mucinous cystadenocarsinoma of low malignant potential) of the pancreas: a clinicopathologic study of 130 cases. Am J Surg Pathol 1999; 23: 1-16.
Tseng J.F. Management of serous cystadenoma of the pancreas. J Gastrointest Surg 2008; 12: 408-410.
Warshaw A.L., Compton C.C., Lewandrowski K. et al. Cystic tumors of the pancreas. New clinical, radiologic, and pathologic observations in 67 patients. Ann Surg 1990; 212: 432-445.
Wilentz R.F., Albores-Saavedra J., Zahurak M. et al. Pathologic examination accurately predicts prognosis in mucinous cystic neoplasms of the pancreas. Am J Surg Pathol 1999; 23: 1320-1327.
Wilentz R.E., Albores-Saavedra J., Hruban R.H. Mucinous cystic neoplasms of the pancreas. Semin Diagn Pathol 2000; 17: 31-43.
Yuan D., Yu W. et al. Characterization and diagnostic accuracy of serous cystadenomas and mucinous neoplasms of the pancreas with multi-slice helical computed tomography. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2007; 29: 2: 232-237.
Zamboni G., Scarpa A., Bogina G. et al. Mucinous cystic tumors of the pancreas: clinicopathological features, prognosis, and relationship to other mucinous cystic tumors. Am J Surg Pathol 1999; 23: 410-422.

Close metadata