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Fomichev A.V.

National Medical Research Center named after Academician E. N. Meshalkin

Kaldar K.N.

Meshalkin National Medical Research Center

Zaynobidinov Sh.Sh.

Meshalkin National Medical Research Center

Protopopov A.V.

Meshalkin National Medical Research Center

Zhulkov M.O.

Meshalkin National Medical Research Center

Khvan D.S.

Meshalkin National Medical Research Center

Doronin D.V.

Meshalkin National Medical Research Center

Sirota D.A.

Meshalkin National Medical Research Center;
Novosibirsk State Medical University

Ex vivo coronary angiography using hearts from older donors

Authors:

Fomichev A.V., Kaldar K.N., Zaynobidinov Sh.Sh., Protopopov A.V., Zhulkov M.O., Khvan D.S., Doronin D.V., Sirota D.A.

More about the authors

Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2025;18(1): 66‑72

DOI: 10.17116/kardio20251801166

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Table of contents

EX VIVO CORONARY ANGIOGRAPHY USING HEARTS FROM OLDER DONORS
EX VIVO CORONARY ANGIOGRAPHY USING HEARTS FROM OLDER DONORS

To cite this article:

Fomichev AV, Kaldar KN, Zaynobidinov ShSh, et al. . Ex vivo coronary angiography using hearts from older donors. Russian Journal of Cardiology and Cardiovascular Surgery. 2025;18(1):66‑72. (In Russ.)
https://doi.org/10.17116/kardio20251801166

ЭндоКард
Подписка 2026 Кардиология и сердечно-сосудистая хирургия (Russian Journal of Cardiology and Cardiovascular Surgery)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To develop safe ex vivo coronary angiography approach immediately before heart implantation.

MATERIAL AND METHODS

A reservoir-container was developed to place a heart in anatomical position for subsequent coronary angiography. 3D STL drawing was prepared with subsequent 3D printing. The next stage was analysis of laboratory animals with development of novel selective coronary angiography method and series of standard high-quality angiograms. A total of 6 experiments were carried out. Coronary angiography was performed using a General Electric OEC 9900 Elice C-arm.

RESULTS

We developed a non-contrast reservoir-container for donor heart positioning and standard angiography. Ex vivo coronary angiography using pig hearts visualized all coronary arteries in standard projections.

CONCLUSION

Considering older age of donors and features of organ donation system in our country, donor heart coronary status assessment is beyond doubt. We experimentally confirmed safety of ex vivo coronary angiography of a donor heart. A clinical trial and implementation are planned in the future.

Keywords:

ex vivo coronary angiography
heart transplantation
donor heart
angiography

Authors:

Fomichev A.V.

National Medical Research Center named after Academician E. N. Meshalkin

Kaldar K.N.

Meshalkin National Medical Research Center

Zaynobidinov Sh.Sh.

Meshalkin National Medical Research Center

Protopopov A.V.

Meshalkin National Medical Research Center

Zhulkov M.O.

Meshalkin National Medical Research Center

Khvan D.S.

Meshalkin National Medical Research Center

Doronin D.V.

Meshalkin National Medical Research Center

Sirota D.A.

Meshalkin National Medical Research Center;
Novosibirsk State Medical University

Received:

28.02.2024

Accepted:

23.05.2024

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References:

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  2. Roig E, Almenar L, Crespo-Leiro M, et al. Heart transplantation using allografts from older donors: Multicenter study results. J Heart Lung Transplant. 2015;34(6):790-796. 
  3. Smits JM, De Pauw M, de Vries E, et al Donor scoring system for heart transplantation and the impact on patient survival. J Heart Lung Transplant. 2012;31(4):387-397.  https://doi.org/10.1016/j.healun.2011.11.005
  4. Heart transplantation, presence of a transplanted heart, death and rejection of heart transplant. National clinical guidelines. 2023-2024-2025 (03/16/2023). Approved by the Ministry of Health of the Russian Federation. (In Russ.).
  5. Baldwin JC, Anderson JL, Boucek MM, et al. 24th Bethesda conference: Cardiac transplantation. Task Force 2: Donor guidelines. J Am Coll Cardiol. 1993;22(1):15-20.  https://doi.org/10.1016/0735-1097(93)90811-E
  6. Johnstad CM, Fiedler AG. Coronary angiography utilization in the evaluation of a potential heart donor by age: a narrative review. J Thorac Dis. 2021;13(3):1864-1868. https://doi.org/10.21037/jtd-20-2547
  7. Grauhan O, Chang H, Meyer R, et al. Impact of donor-transmitted coronary atherosclerosis: on outcome after heart transplantation. Thorac Cardiovasc Surg. 2005;5:53-65.  https://doi.org/10.1055/s-2005-861989
  8. Ghodsizad 1 A, Bordel V, Ungerer M, et al. Ex vivo coronary angiography of a donor heart in the organ care system. Heart surg forum. 2012;15(3):E161-E163. https://doi.org/10.1532/hsf98.20111146
  9. Mendirichaga R, Kearns M, Pretorius V, et al. Ex Vivo Coronary Angiography and Intravascular Ultrasound of a Donor Heart in the Organ Care System. Journal of the Society for Cardiovascular Angiography & Interventions. 2022;1(4):100342. https://doi.org/10.1016/j.jscai.2022.100342
  10. Anthony C, Michel J, Christofi M, et al. Ex Vivo Coronary Angiographic Evaluation of a Beating Donor Heart. Circulation. 2014;130:e341-e343. https://doi.org/10.1161/CIRCULATIONAHA.114.010289
  11. Sunjaya AF, Sunjaya AP. Combating Donor Organ Shortage: Organ Care System Prolonging Organ Storage Time and Improving the Outcome of Heart Transplantations. Cardiovasc Ther. 2019;2019:9482797. https://doi.org/10.1155/2019/9482797
  12. Robicsek F, Masters TN, Thomley AM, et al. Bench coronary cineangiography. A possible way to increase the number of hearts available for transplantation. J Thorac Cardiovasc Surg. 1992;103(3):490-495.  https://doi.org/10.1016/s0022-5223(19)34990-6
  13. Lee CC, Aruny JE, Laurence RG, et al. Bench coronary angiography: a potentially useful method to assess coronary artery disease in the older donor heart without catheterization laboratory angiography. J Heart Lung Transplant. 1992;11(4 Pt 1):693-697. 
  14. Zhulkov MO, Sirota DA, Zykov IS, et al. Evaluation of coronary status of donor heart by non-selective coronary angiography ex vivo in the experiment. Vestnik transplantologii i iskusstvennyh organov. 2022;24:42. (In Russ.).
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