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Nichay N.R.

Meshalkin National Medical Research Center;
Novosibirsk State Medical University

Gorbatykh Yu.N.

Meshalkin National Medical Research Center

Voitov A.V.

Meshalkin National Medical Research Center

Soynov I.A.

Meshalkin National Medical Research Center

Kulyabin Yu.Yu.

National Medical Research Center

Khapaev T.S.

Meshalkin National Medical Research Center

Arkhipov A.N.

National Medical Research Center

Anikina N.V.

Meshalkin National Medical Research Center

Dokuchaeva A.A.

Meshalkin National Medical Research Center

Bogachev-Prokofiev A.V.

Meshalkin National Medical Research Center

Infective endocarditis in pediatric patients with pulmonary graft

Authors:

Nichay N.R., Gorbatykh Yu.N., Voitov A.V., Soynov I.A., Kulyabin Yu.Yu., Khapaev T.S., Arkhipov A.N., Anikina N.V., Dokuchaeva A.A., Bogachev-Prokofiev A.V.

More about the authors

Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2024;17(2): 139‑151

DOI: 10.17116/kardio202417021139

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Table of contents

INFECTIVE ENDOCARDITIS IN PEDIATRIC PATIENTS WITH PULMONARY GRAFT
INFECTIVE ENDOCARDITIS IN PEDIATRIC PATIENTS WITH PULMONARY GRAFT

To cite this article:

Nichay NR, Gorbatykh YuN, Voitov AV, et al. . Infective endocarditis in pediatric patients with pulmonary graft. Russian Journal of Cardiology and Cardiovascular Surgery. 2024;17(2):139‑151. (In Russ.)
https://doi.org/10.17116/kardio202417021139

Подписка 2025-2 (Russian Journal of Cardiology and Cardiovascular Surgery)
 
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OBJECTIVE

To assess the risk of infective endocarditis (IE) in pediatric patients after implantation of different pulmonary conduits.

MATERIAL AND METHODS

There were 403 pediatric patients aged 0—18 years who underwent implantation of pulmonary valved conduit between 2000 and 2016.

RESULTS

A total of 497 conduits were implanted including glutaraldehyde (GA)-treated bovine jugular vein (contegra) (n=181, 36.4%); GA-treated xenopericardial conduit (BioLAB) (n=84, 16.9%); diepoxyde (DE)-treated xenopericardial conduit with porcine aortic root (AB-composite) (n=65, 13.1%); DE-treated xenopericardial conduit (Pilon) (n=32, 6.4%) and cryopreserved pulmonary homograft (n=135, 27.2%). Primary implantation was made in 385 cases (77.5%), conduit reimplantation — in 112 cases (22.5%). Median follow-up was 6.75 years (IQR 4.0—9.3 years). One or more delayed re-interventions were carried out in 202 cases. Of these, 190 conduits were replaced due to dysfunction. IE was diagnosed in 26 (5.2%) patients in 2 days — 14 years after procedure (7 months; IQR 0.5 months — 4 years): Contegra — 2.8%, BioLAB — 7.1%, AB-composite — 6.2%, Pilon — 9.4%, Homograft — 5.9%. Five-year and ten-year freedom from IE was 94% and 92%, respectively. Twelve (46.2%) patients underwent removal of infected graft. In other cases (n=14, 53.8%), IE was treated with antibiotics. IE-related mortality was 26.9% (n=7). Risk of IE did not depend on the type of conduit (RR 0.82; 95% CI 0.58—1.16; p=0.257).

CONCLUSION

Conduit-related IE is still associated with high mortality. All types of available conduits are predisposed to infection without any difference among them.

Keywords:

infective endocarditis
pulmonary graft
valved conduit
pulmonary artery replacement
congenital heart defects

Authors:

Nichay N.R.

Meshalkin National Medical Research Center;
Novosibirsk State Medical University

Gorbatykh Yu.N.

Meshalkin National Medical Research Center

Voitov A.V.

Meshalkin National Medical Research Center

Soynov I.A.

Meshalkin National Medical Research Center

Kulyabin Yu.Yu.

National Medical Research Center

Khapaev T.S.

Meshalkin National Medical Research Center

Arkhipov A.N.

National Medical Research Center

Anikina N.V.

Meshalkin National Medical Research Center

Dokuchaeva A.A.

Meshalkin National Medical Research Center

Bogachev-Prokofiev A.V.

Meshalkin National Medical Research Center

Received:

17.10.2023

Accepted:

09.11.2023

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