The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Ngo Bilong E.AV.

Sechenov First Moscow State Medical University

Rozhkov A.N.

The first Moscow State Medical University named after I.M. Sechenov (Sechenov University)

Mitina Yu.O.

Skolkovo Institute of Science and Technologies

Vasil’ev S.V.

Expert Legal Centre LLC

Zhelankin A.V.

Federal Scientific Clinical Center of physico-chemical medicine

Generozov E.V.

Federal Research and Clinical Center of Physical and Chemical Medicine

Schekochikhin D.Yu.

The first Moscow State Medical University named after I.M. Sechenov (Sechenov University)

Ternovoy S.K.

National Medical Research Center of Cardiology

Akselrod A.S.

The first Moscow State Medical University named after I.M. Sechenov (Sechenov University)

Upregulation of miRNA 23A-3P, 146A-5P AND 150A-5P as a possible diagnostic marker of unstable angina in patients with thoracic aortic aneurysm

Authors:

Ngo Bilong E.AV., Rozhkov A.N., Mitina Yu.O., Vasil’ev S.V., Zhelankin A.V., Generozov E.V., Schekochikhin D.Yu., Ternovoy S.K., Akselrod A.S.

More about the authors

Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2022;15(4): 385‑392

DOI: 10.17116/kardio202215041385

Read: 2040 times

Contact the author
Table of contents

UPREGULATION OF MIRNA 23A-3P, 146A-5P AND 150A-5P AS A POSSIBLE DIAGNOSTIC MARKER OF UNSTABLE ANGINA IN PATIENTS WITH THORACIC AORTIC ANEURYSM
UPREGULATION OF MIRNA 23A-3P, 146A-5P AND 150A-5P AS A POSSIBLE DIAGNOSTIC MARKER OF UNSTABLE ANGINA IN PATIENTS WITH THORACIC AORTIC ANEURYSM

To cite this article:

Ngo Bilong EAV, Rozhkov AN, Mitina YuO, et al. Upregulation of miRNA 23A-3P, 146A-5P AND 150A-5P as a possible diagnostic marker of unstable angina in patients with thoracic aortic aneurysm. Russian Journal of Cardiology and Cardiovascular Surgery. 2022;15(4):385‑392. (In Russ.)
https://doi.org/10.17116/kardio202215041385

Подписка 2026 Кардиология и сердечно-сосудистая хирургия (Russian Journal of Cardiology and Cardiovascular Surgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Surgical treatment of asce­nding aortic aneurysm with proximal stent graft-induced new entry after previous thoracic endo­vascular aortic repair. Russian Journal of Cardiology and Cardiovascular Surgery. 2025;(6):719-722
Extracellular vesi­cles and their role in endo­metrial rece­ptivity in patients with recu­rrent implantation failure. Russian Journal of Human Reproduction. 2025;(4):46-52
Possibilities of inte­ractions of circular RNAS with nucleic acids and proteins. Mole­cular Gene­tics, Microbiology and Viro­logy. 2025;(4-2):28-32
Diagnostic pote­ntial of small non-coding RNAs in pipe­lle biopsy mate­rial of euto­pic endo­metrium. Russian Journal of Human Reproduction. 2026;(1):92-102
MicroRNA dere­gulation as a method for asse­ssing the effe­ctiveness of brachytherapy for choroidal mela­noma. Russian Annals of Ophthalmology. 2026;(1):21-26
Prospects for retroelement-targeted therapy of schi­zophrenia. S.S. Korsakov Journal of Neurology and Psychiatry. 2026;(4):22-27
Prognostic value of miR-130, miR-148, miR-194 and miR-605 serum expression in glioblastoma patients. Burdenko's Journal of Neurosurgery. 2026;(3):20-26
Abstract:

OBJECTIVE

To study the complex of circulating microRNAs as possible diagnostically significant markers in patients with thoracic aortic aneurysms (TAA) and various clinical manifestations of coronary artery disease (CAD).

MATERIAL AND METHODS

Our study included 33 patients: 15 patients with TAA and no CAD, 5 ones with TAA and stable CAD, 13 patients with TAA and unstable CAD. The control group consisted of 17 people without signs of coronary atherosclerosis. We determined the levels of 12 circulating microRNAs.

RESULTS

Expression of 3 miRNAs was significantly higher in patients with TAA and unstable CAD: miRNA 23a-3p by 3 times (p=0.0094), miRNA 146-5p by 3 times (p=0.0123), miRNA 150-5p by 12 times (p=0.0096). We obtained the most optimal diagnostic value for combination of all 3 miRNA (AUC=0.8161, p<0.001).

CONCLUSION

The circulating miRNAs 23a-3p, 146a-5p and 150-5p are possible diagnostic biomarkers of unstable CAD in patients with TAA.

Keywords:

thoracic aortic aneurysm
unstable CAD
miRNA

Authors:

Ngo Bilong E.AV.

Sechenov First Moscow State Medical University

Rozhkov A.N.

The first Moscow State Medical University named after I.M. Sechenov (Sechenov University)

Mitina Yu.O.

Skolkovo Institute of Science and Technologies

Vasil’ev S.V.

Expert Legal Centre LLC

Zhelankin A.V.

Federal Scientific Clinical Center of physico-chemical medicine

Generozov E.V.

Federal Research and Clinical Center of Physical and Chemical Medicine

Schekochikhin D.Yu.

The first Moscow State Medical University named after I.M. Sechenov (Sechenov University)

Ternovoy S.K.

National Medical Research Center of Cardiology

Akselrod A.S.

The first Moscow State Medical University named after I.M. Sechenov (Sechenov University)

Received:

17.09.2021

Accepted:

29.11.2021

Close metadata

References:

  1. Girardi LN, Rabotnikov Y, Avgerinos DV. Preoperative percutaneous coronary intervention in patients undergoing open thoracoabdominal and descending thoracic aneurysm repair. J Thorac Cardiovasc Surg. 2014;147:163-168. 
  2. Nakai M, Shimamoto M, Yamasaki F, et al. Surgical treatment of thoracic aortic aneurysmin patients with concomitant coronary artery disease. Jpn J Thorac Cardiovasc Surg. 2005;53:84-87. 
  3. Gertz ZM, Levitt SA, Epps KC, et al. Cardiac catheterization in patients with ascending aortic aneurysms: Safety, success, and prevalence of coronary artery disease. J Invasive Cardiol. 2014;26:241-244. 
  4. Ueda T, Shimizu H, Shin H, et al. Detection and management of concomitant coronary artery disease in patients undergoing thoracic aortic surgery. Jpn J Thorac Cardiovasc Surg. 2001;49:424-430. 
  5. Iba Y, Minatoya K, Matsuda H, et al. Contemporary open aortic arch repair with selective cerebral perfusion in the era of endovascular aortic repair. J Thorac Cardiovasc Surg. 2013;145:72-77. 
  6. Svensson LG, Crawford ES, Hess KR, et al. Deep hypothermia with circulatory arrest. Determinants of stroke and early mortality in 656 patients. J Thorac Cardiovasc Surg. 1993;106:19-28. 
  7. Svensson LG, Crawford ES, Hess KR, et al. Experience with 1509 patients undergoing thoracoabdominal aortic operations. J Vasc Surg. 1993;17:357-368. 
  8. Kouchoukos NT, Dougenis D. Surgery of the thoracic aorta. NEngl J Med. 1997;336:1876-1889.
  9. Hiratzka LF, Bakris GL, Beckman JA, et al. 2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guidelines for the diagnosis and management of patients with thoracic aortic disease. A Report of the AmericanCollege of Cardiology Foundation/American Heart AssociationTask Force on Practice Guidelines, American Association forThoracic Surgery, American College of Radiology, AmericanStroke Association, Society of Cardiovascular Anesthesiologists,Society for Cardiovascular Angiography and Interventions,Society of Interventional Radiology, Society of Thoracic Surgeons,and Society for Vascular Medicine. J Am Coll Cardiol. 2010;55:27-129. 
  10. Daimon M, Miyata H, Motomura N, et al. Outcomes of Thoracic Aortic Surgery in Patients With Coronary Artery Disease ― Based on the Japan Adult Cardiovascular Surgery Database. Circulation Journal. 2019;83(5):978-984.  https://doi.org/10.1253/circj.CJ-18-0703
  11. Toshihiro F, Tomoki S, Minoru T, Shuichiro T. Outcomes of total aortic arch replacement with coronary artery bypass grafting. Interactive CardioVascular and Thoracic Surgery. 2011;13:3:284-287.  https://doi.org/10.1510/icvts.2011.275685
  12. Watanabe K, Watanabe T, Otaki Y, et al. Impact of pre-operative coronary artery disease on the clinical outcomes of patients with aortic aneurysms. Heart Vessels. 2021;36:308-314.  https://doi.org/10.1007/s00380-020-01700-2
  13. Yokoyama H. Aortic arch aneurysm complicated with coronary artery disease: still a surgical challenge? Ann Thorac Cardiovasc Surg. 2002;8(2):62-68. 
  14. Han H, et al. MiR-34a, miR-21 and miR-23a as potential biomarkers for coronary artery disease: a pilot microarray study and confirmation in a 32 patient cohort. Exp Mol Med. 2015;47:e138.
  15. Di Y, et al. miR-23 regulate the pathogenesis of patients with coronary artery disease. Int J Cardiol. 2015;8:11759-11769.
  16. Dong J, Bao J, Feng R, et al. Circulating microRNAs: a novel potential biomarker for diagnosing acute aortic dissection. Sci Rep. 2017;7:12784. https://doi.org/10.1038/s41598-017-13104-w
  17. Takahashi Y, Satoh M, Minami Y, et al. Expression of miR-146a/b is associated with the Toll-like receptor 4 signal in coronary artery disease: effect of renin-angiotensin system blockade and statins on miRNA-146a/b and Toll-like receptor 4 levels. Clin Sci (Lond). 2010;119:395-405. 
  18. Scrutinio D, Conserva F, Passantino A, et al. Circulating microRNA-150-5p as a novel biomarker for advanced heart failure: A genome-wide prospective study. J Heart Lung Transplant. 2017;36(6):616-624.  https://doi.org/10.1016/j.healun.2017.02.008
  19. Zeller T, Keller T, Ojeda F, et al. Assessment of microRNAs in patients with unstable angina pectoris. Eur Heart J. 2014;35:2106-2114.
  20. Gareev IF, Beylerli OA. Circulating microRNAs as biomarkers: what are perspectives? Profilacticheskaya medicina. 2018;21(6):142-150. (In Russ.). https://doi.org/10.17116/profmed201821061142
  21. Feinberg MW, Moore KJ. MicroRNA regulation of atherosclerosis. Circulation research. 2016;118(4):703-720.  https://doi.org/10.1161/CIRCRESAHA.115.306300
  22. Li Y, Tan W, Ye F, et al. Identification of microRNAs and genes as biomarkers of atrial fibrillation using a bioinformatics approach. Journal of International Medical Research. 2019;47(8):3580-3589. https://doi.org/10.1177/0300060519852235
  23. Cortez MA, Bueso-Ramos C, Ferdin J, et al. MicroRNAs in body fluids — the mix of hormones and biomarkers. Nature reviews Clinical oncology. 2011;8(8):467.  https://doi.org/10.1038/nrclinonc.2011.76
  24. Bronze-da-Rocha E. MicroRNAs Expression Profiles in Cardiovascular Diseases. Biomed Res Int. 2014;985408. https://doi.org/10.1155/2014/985408
  25. Romaine SP, Tomaszewski M, Condorelli G, et al. MicroRNAs in cardiovascular disease: an introduction for clinicians. Heart. 2015;101(12):921-928.  https://doi.org/10.1136/heartjnl-2013-305402
  26. Navickas R, Gal D, Laucevičius A, et al. Identifying circulating microRNAs as biomarkers of cardiovascular disease: a systematic review. Cardiovascular research. 2016;111(4):322-337.  https://doi.org/10.1093/cvr/cvw174
  27. Zhou SS, Jin JP, Wang JQ, et al. MiRNAs in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges. Acta Pharmacologica Sinica. 2018;39(7):1073-1084. https://doi.org/10.1038/aps.2018.30
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.