Hypertrophic cardiomyopathy (HCM) is a common disease and one of the causes of sudden death. A variety of forms of this disease has led to development of a large number of variants of surgical treatment. Aim. To evaluate the results of different surgical treatment of patients with HCM operated in Regional Clinical Cardiology Clinic. Material and methods. In Regional Dispensary 93 patients with HCM underwent surgical treatment for the period from 2005 to 2014. Patients were divided into 3 groups depending on the type of surgery. In group I (73 patients) transaortic septal myectomy (Morrow’s surgery) was performed. Group II (15 patients) included patients after transcoronary septal ablation. In group III (5 patients) transaortic septal myectomy, papillary muscles resection and mitral valve replacement were performed. Immediate, mid-term and long-term results (within 12—140 months) were assessed at follow-examination of the patient, as well as according to echocardiography data. Results. 5-year survival in Group I was 95%. LVOT pressure gradient has not increased, symptoms of heart failure corresponded to NYHA functional class I. In 18 months after surgery all patients in Group II are alive. LVOT pressure gradient insignificantly increased but remained at a satisfactory level (less than 30 mm Hg). Heart failure class was significantly lower compared to preoperative value. 3-year survival rate in group III was 80%. Intracardiac hemodynamics remained satisfactory. Symptoms of heart failure corresponded to NYHA functional class I.