We described a new method of unilateral antegrade cerebral perfusion through the brachiocephalic trunk during aortic arch surgery. According to infrared spectroscopy data it was shown that this type of unilateral perfusion provides sufficient protection of both cerebral hemispheres from ischemia at different surgical stages including circulatory arrest. The incidence of postoperative persistent and transient neurological complications was 2.6 and 5.3% respectively. Mortality was 13.2% and was not due to neurological causes. It is concluded that unilateral antegrade cerebral perfusion through the brachiocephalic trunk during reconstructive aortic arch surgery is a relatively safe and effective method in the period of circulatory arrest.