Associations of aortic valve area and calcification with diastolic heart function and high lipoprotein(a) levels in a population study

Mirolyubova O.A.; Kokurina D.A.; Ryabikov A.N.; Semenova I.A.; Antonov A.B.; Kudryavtsev A.V.

doi:https://doi.org/10.17116/Cardiobulletin20252002127

Mirolyubova O.A.

Northern State Medical University

ORCID: 0000-0003-4562-8398

Kokurina D.A.

Northern State Medical University

ORCID: 0009-0007-2583-5265

Ryabikov A.N.

Research Institute of Internal and Preventive Medicine;
Novosibirsk State Medical University

ORCID: 0000-0001-9868-855X

Semenova I.A.

Northern State Medical University

ORCID: 0009-0004-8401-131X

Antonov A.B.

Northern State Medical University

ORCID: 0009-0004-1717-9817

Kudryavtsev A.V.

Northern State Medical University;
UiT The Arctic University of Norway

ORCID: 0000-0001-8902-8947

Associations of aortic valve area and calcification with diastolic heart function and high lipoprotein(a) levels in a population study

Authors:

Mirolyubova O.A., Kokurina D.A., Ryabikov A.N., Semenova I.A., Antonov A.B., Kudryavtsev A.V.

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Journal: Russian Cardiology Bulletin. 2025;20(2): 27‑36

DOI: 10.17116/Cardiobulletin20252002127

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To cite this article:

Mirolyubova OA, Kokurina DA, Ryabikov AN, Semenova IA, Antonov AB, Kudryavtsev AV. Associations of aortic valve area and calcification with diastolic heart function and high lipoprotein(a) levels in a population study. Russian Cardiology Bulletin. 2025;20(2):27‑36. (In Russ.)
https://doi.org/10.17116/Cardiobulletin20252002127

Подписка 2026 Кардиологический вестник (Russian Cardiology Bulletin)

Использование инфографики авторами научных работ

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OBJECTIVE

To assess diastolic cardiac function depending on aortic valve area (AVA) and relationship between calcification and Lp(a) in adult urban population.

MATERIAL AND METHODS

Analysis was carried out in a sample of participants in the population-based cross-sectional study “Know your heart” (Arkhangelsk, 2015—2017). Age of patients was 35-69 years (n=2372). Survey, laboratory and echocardiography data were used. Results were adjusted for gender and age.

RESULTS

We identified 3 groups depending on AVA (n=2105): group 1 — AVA>1.5 cm², (reference group), 94.5% (n=1989); group 2 — AVA 1.0—1.5 cm², 4.7% (n=98); group 3 — AVA<1.0 cm² (severe AS), 0.9% (n=18). Mean transvalvular pressure gradient did not correspond to severity of AS in the 3^rd group, and ejection fraction (EF) was >50%. In the same group, atrial fibrillation, cancer and abdominal obesity were more common. E lateral <10 cm/sec was associated with AVA. The odds ratio was 1.97 (95% CI 1.22—3.19, p=0.006) for the 2^nd group and 3.88 (95% CI 1.02—14.73, p=0.047) for the 3^rd group. The index E/e (LV filling pressure) negatively correlated with AVA (β=—0.12; p <0.001). Prevalence of aortic valve calcification was 6.9% (8.8% among men and 5.6% among women). Lp(a) was independently associated with aortic valve calcification: OR=1.99 (95% CI 1.21—3.26, p=0.006) for 50—100 mg/dL, 4.64 (95% CI 2.45—8.79, p <0.001) for >100 mg/dL compared to the reference category of Lp(a) <50 mg/dL.

CONCLUSION

In population of Arkhangelsk residents aged 35—69 years, diastolic cardiac dysfunction increases as AVA decreases. Lp(a) is independently associated with aortic valve calcification. The risk of aortic valve calcification increases with Lp(a) concentration >50 mg/dL.

Keywords:

Low-gradient aortic stenosis

diastolic function

aortic valve calcification

lipoprotein(a)

Authors:

Mirolyubova O.A.

Northern State Medical University

ORCID: 0000-0003-4562-8398

Kokurina D.A.

Northern State Medical University

ORCID: 0009-0007-2583-5265

Ryabikov A.N.

Research Institute of Internal and Preventive Medicine;
Novosibirsk State Medical University

ORCID: 0000-0001-9868-855X

Semenova I.A.

Northern State Medical University

ORCID: 0009-0004-8401-131X

Antonov A.B.

Northern State Medical University

ORCID: 0009-0004-1717-9817

Kudryavtsev A.V.

Northern State Medical University;
UiT The Arctic University of Norway

ORCID: 0000-0001-8902-8947

Received:

22.03.2024

Accepted:

07.05.2025

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